With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1191028-50-8,6-Bromo-5-chloro-1H-indole,as a common compound, the synthetic route is as follows.
under nitrogen 6-bromo-5-chloro-1H-indole (7.89g, 34.3mmol) in THF/H2O (80 ml/20 ml) , 2-Nitrophenylboronic acid (5.71g, 34.3mmol), and K2CO3(14.2g, 0.103mol) , Pd (PPh3)4(1.98g, 1.71mmol) are added , stirring 4 hours in 85 C . After, after cooled to room temperature, was of concentrating the THF. Furthermore, ethyl which has organic layer which is then subjected to reverse phase, MgSO4in organic layer to the second interlayer, filters the concentrated within, column chromatography for purifying the 5-chloro-6 -(2-nitrophenyl) -1H-indole (6.72g, yield: 72%) is obtained., 1191028-50-8
As the paragraph descriping shows that 1191028-50-8 is playing an increasingly important role.
Reference£º
Patent; Doosan Corporation; Kim, Dae Hyong; Kim, Hoe Moon; Lee, Yong – Hwan; Pek, Young Mi; Park, Hoo Chol; Lee, Chang Joon; Sin, Jin Yong; (81 pag.)KR101601357; (2016); B1;,
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