Chemistry, like all the natural sciences, SDS of cas: 1194-98-5, begins with the direct observation of nature— in this case, of matter.1194-98-5, Name is 2,5-Dihydroxybenzaldehyde, SMILES is O=CC1=CC(O)=CC=C1O, belongs to indole-building-block compound. In a document, author is Li, Yi, introduce the new discover.
The addition of electron-deficient radicals to theC2position of indoles has been described in the literature as opposed to electrophilic addition at theC3 position. Density functional theory calculations were used to understand the switch in regioselectivity fromC3toC2for indole to undergo radical additions. Electron deficient radicals have a lower barrier for the reaction atC2 and a lower energy radical intermediate that benefits from benzylic radical stabilization. Trifluoromethyl radical addition has a lower energy barrier than acetonitrile radical, and theC3 addition transition state is just 0.8 kcal/mol higher thanC2. This is supported by experimental observations.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1194-98-5. SDS of cas: 1194-98-5.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles