Category: 1196-69-6

Analyzing the synthesis route of 1196-69-6

1196-69-6, The synthetic route of 1196-69-6 has been constantly updated, and we look forward to future research findings.

1196-69-6, Indole-5-carboxaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

S221 10 parts by mole of bromine n-butane was slowly added to 400 parts by mole of DMSO, and then 15 parts by mole of indole aldehyde 5a and 15 parts by mole of KOH were added to the DMSO to form a mixed liquid; S222 The mixture was stirred at room temperature for 9h, then 5000 molar parts of water were added and extracted with dichloromethane; S223 The combined methylene chloride layers were washed sequentially with water and brine, dried over anhydrous Na2SO4 and evaporated to dryness under reduced pressure to give a residue. The residue was purified by column chromatography on silica gel using a volume ratio of 2: 1 petroleum ether / ethyl acetate to give indoledehyde 4b.

1196-69-6, The synthetic route of 1196-69-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wenzhou University; Huang Xiaobo; Qian Lebin; Wu Huayue; Zhou Yibin; Liu Miaochang; Gao Wenxia; Ding Jinchang; (34 pag.)CN107382982; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Analyzing the synthesis route of 1196-69-6

As the paragraph descriping shows that 1196-69-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-69-6,Indole-5-carboxaldehyde,as a common compound, the synthetic route is as follows.

To a solution of indole-3-carboxaldehyde (16, 28.5 g, 100 mmol) in ethanol (500 mL) at room temperature was added potassium hydroxide (6.2 g, 110 mmol); the mixture was stirred until total solubilization. The ethanol was completely removed in a vacuum and acetone (250 mL) was added followed by benzenesulfonyl chloride (19.4 g, 110 mmol). The precipitate was filtered off, and the filtrate was concentrated and recrystallized from methanol to give a white solid. Yield: 40%., 1196-69-6

As the paragraph descriping shows that 1196-69-6 is playing an increasingly important role.

Reference£º
Article; Chen, Jianjun; Li, Chien-Ming; Wang, Jin; Ahn, Sunjoo; Wang, Zhao; Lu, Yan; Dalton, James T.; Miller, Duane D.; Li, Wei; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4782 – 4795;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 1196-69-6

The synthetic route of 1196-69-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-69-6,Indole-5-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Under air, a 20 mL of Schlenk tube equipped with a stir bar was charged with indole 1 (0.2 mmol, 1 equiv),TMEDA (75 muL, 0.5 mmol, 2.5 equiv), Na2CO3 (42.4 mg, 0.4mmol, 2.0 equiv), 1,4-dioxane (0.5 mL) and H2O (100 muL). Then I2 (101.5 mg, 0.4 mmol, 2.0 equiv) was added and the tube was sealed with a rubber plug and charged with O2. The reaction mixture was stirred at 100 C for 36 h in oil bath. After cooling to room temperature, the resultant mixture was evaporated with EtOAc (20 mL) under reduced pressure and the residue was purified by flash column chromatography on a silica gel to give the products.

The synthetic route of 1196-69-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Bo; Liu, Bin; Chen, Jianbin; Wang, Jiehui; Liu, Miaochang; Tetrahedron Letters; vol. 55; 41; (2014); p. 5618 – 5621;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles