Category: 120-14-9

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives published in 2021.0. Recommanded Product: 3,4-Dimethoxybenzaldehyde, Reprint Addresses Shi, LQ; Wang, KM; Ke, SY (corresponding author), Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Carbazole alkaloids is an important class of natural products with diverse biological functions. So, the aim of this article is to explore new chemical entities containing carbazole scaffold as potential novel cytotoxic agents based on our developed three-component indole-to-carbazole reaction. Two series of carbazole derivatives were designed and synthesized, and their in vitro cytotoxic activities against three cell lines (A875, HepG2, and MARC145) were evaluated. The results indicated that some of these carbazole derivatives exhibited significantly good cytotoxic activities against tested cell lines compared with the control 5-fluorouracil (5-FU). Especially, carbazole acylhydrazone compounds 7g and 7p displayed high inhibitory activity on cancer cells, but almost no activity on normal cells. Further analysis of induced apoptosis for potential compounds indicated that the potential antitumor agents induced cell death in A875 cells at least partly (initially) by apoptosis, which might be used as promising lead scaffold for discovery of novel carbazole-type cytotoxic agents.

Welcome to talk about 120-14-9, If you have any questions, you can contact Huang, WB; Gao, ZL; Zhang, ZG; Fang, W; Wang, ZQ; Wan, ZY; Shi, LQ; Wang, KM; Ke, SY or send Email.. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines WOS:000651228800015 published article about GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION in [Aziz, Marian W.; Elgendy, Adel A.] Misr Int Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt; [Kamal, Aliaa M.; Mohamed, Khaled O.] Cairo Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Cairo, Egypt; [Kamal, Aliaa M.] October Univ Modern Sci & Arts MSA, Fac Pharm, Dept Pharmaceut Chem, Giza, Egypt in 2021.0, Cited 43.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Safety of 3,4-Dimethoxybenzaldehyde

New acetamide (IV a-e) and 1,3-thiazolidinone derivatives (VII a-e) were designed, synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines along with their lead compounds (erlotinib and gefitinib). The newly designed compounds were prepared according to the adopted procedures in schemes 1 and 2 from their quinazolinone parents. 3D QSAR pharmacophore and docking molecular modeling protocols were conducted using Discovery Studio program, beside a full biological assay for these compounds. The cytotoxicity evaluation demonstrated that compounds IVb, IVc, VIIa, VIIb, VIId exhibited potent cytotoxic activities against both MCF-7 and A549 cell lines. Moreover, the molecular modeling studies corroborated to the affinity of the compounds towards EGFR. Consequently, these five compounds were then screened for their EGFR inhibition and evaluated as well for their toxicity to normal cells, which revealed that the acetamide derivative IVc and the thiazolidinone derivative VIIa were the most potent and least toxic. DNA flow cytometry analysis was conducted for compounds IVc and VIIa, which indicated that they both induced arrest at G2/M phase of the cell cycle.

Safety of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Aziz, MW; Kamal, AM; Mohamed, KO; Elgendy, AA or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 NEW J CHEM published article about MAGNETICALLY RETRIEVABLE CATALYSTS; POT MULTICOMPONENT SYNTHESIS; BIOLOGICAL EVALUATION; EFFICIENT; PYRIMIDINE; DESIGN; NANOCOMPOSITE; NANOMATERIALS; OPTIMIZATION; INHIBITORS in [Khalaj, Mehdi] Islamic Azad Univ Buinzahra, Dept Chem, Buinzahra Branch, Buin Zahra, Iran; [Taherkhani, Mahboubeh] Islamic Azad Univ, Coll Sci, Dept Chem, Takestan Branch, Takestan, Iran; [Kalhor, Mehdi] Payame Noor Univ, Dept Organ Chem, Tehran 193954697, Iran in 2021, Cited 44. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Category: indole-building-block

NiFe2O4@SiO2 grafted di(3-propylsulfonic acid) was prepared by a facile method and characterized using XRD, FT-IR, SEM-EDX, TGA, and BET techniques. The XRD pattern shows the characteristic peaks of the cubic structure for NiFe2O4. The presence of sulfonic acid groups was confirmed by FT-IR analysis. The catalyst was used for the preparation of chromeno[4,3-d]pyrido[1,2-a]pyrimidine derivatives via the three-component condensation reaction of 4-hydroxycoumarin, aldehydes, and 2-aminopyridines under US irradiation. The effects of solvent, temperature, and catalyst dosage on product formation under the reaction conditions were investigated. The simple procedure, good yields, short reaction times, and catalyst recovery are some of the key advantages of this method.

Category: indole-building-block. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Qu, BC; Jiang, JQ; Mao, XQ; Dong, GB; Liu, YJ; Li, L; Zhao, HX in TAYLOR & FRANCIS LTD published article about in [Qu, Baocheng; Liu, Yijun] Dalian Ocean Univ, Dalian, Peoples R China; [Qu, Baocheng] Minist Educ, Key Lab Environm Controlled Aquaculture, Dalian, Peoples R China; [Jiang, Jingqiu; Zhao, Hongxia] Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn, Minist Educ, Dalian, Peoples R China; [Mao, Xiqin; Dong, Guangbin; Li, Li] Dalian Ctr Certificat & Food & Drug Control, Dalian, Peoples R China in 2021.0, Cited 37.0. SDS of cas: 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient and simple method for determining vanillin, methyl vanillin and ethyl vanillin in milk and dairy products was developed using a liquid-liquid extraction (LLE) procedure coupled to high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Different extraction procedures were tested and optimised by spiking three vanillin compounds into a blank matrix in which none of any food additives were detected, and the extraction with acetonitrile solution and n-hexane as cleaning sorbent allowed an efficient recovery of 87.6-101.7% with RSDs less than 5%. The limit of detection (LOD) ranged from 6.2 to 20.1 mu g/kg. High sensitivity, accuracy and selectivity were found for the in-house validated method, which can eliminate the interferences from complicated matrices effectively, and fulfil the quality criteria for routine laboratory application for real samples. The developed method was then finally applied to screen the three analytes in 65 milk and dairy products including infant formula milk powders from local markets to check for compliance with Chinese Regulation. Concentrations of the total vanillin and ethyl vanillin ranged from 0.0323 to 246.3 mg/kg, which is within the limits of Chinese regulations.

SDS of cas: 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents WOS:000661282500005 published article about RESISTANT STAPHYLOCOCCUS-AUREUS; DIVISION PROTEIN FTSZ; IN-VITRO; INHIBITORS; CYTOKINESIS; BACTERIA; INSIGHTS in [Song, Di; Zhang, Nan; Zhang, Panpan; Zhang, Na; Chen, Weijin; Zhang, Long; Guo, Ting; Gu, Xiaotong; Ma, Shutao] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Wenhua Rd, Jinan 250012, Peoples R China in 2021, Cited 51. COA of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

With the increasing incidence of antibiotic resistance, new antibacterial agents having novel mechanisms of action hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Four novel series of substituted 9-arylalkyl-10-methylacridinium derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. The results demonstrated that they exhibited broad-spectrum activities with substantial efficacy against MRSA and VRE, which were superior or comparable to the berberine, sanguinarine, linezolid, ciprofloxacin and vancomycin. In particular, the most promising compound 15f showed rapid bactericidal properties, which avoid the emergence of drug resistance. However, 15f showed no inhibitory effect on Gram-negative bacteria but biofilm formation study gave possible answers. Further target identification and mechanistic studies revealed that 15f functioned as an effective FtsZ inhibitor to alter the dynamics of FtsZ self-polymerization, which resulted in termination of the cell division and caused cell death. Further cytotoxicity and animal studies demonstrated that 15f not only displayed efficacy in a murine model of bacteremia in vivo, but also no significant hemolysis to mammalian cells. Overall, this compound with novel skeleton could serve as an antibacterial lead of FtsZ inhibitor for further evaluation of drug-likeness. (C) 2021 Elsevier Masson SAS. All rights reserved.

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Song, D; Zhang, N; Zhang, PP; Zhang, N; Chen, WJ; Zhang, L; Guo, T; Gu, XT; Ma, ST or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about C-H FUNCTIONALIZATION; PHOTOREDOX CATALYSIS; CARBONYL-COMPOUNDS; COUPLING REACTIONS; NICKEL CATALYSIS; GRIGNARD; HYDROGEN; HALIDES; IMINES; REAGENTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21702113, 22071102, 91956110]; Thousand Talents Plan of Central Plains; Key Scientific Research Projects of Higher Education Institutions in Henan Province [20A150029]; National Science FoundationNational Science Foundation (NSF) [CHE-1554906]; Robert A. Welch FoundationThe Welch Foundation [D-1361]. SDS of cas: 120-14-9. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Zhang, S; Li, LJ; Li, JJ; Shi, JX; Xu, K; Gao, WC; Zong, LY; Li, GG; Findlater, M. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Arylation of carbonyls, one of the most common approaches toward alcohols, has received tremendous attention, as alcohols are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochemical arylation can fill the gap. By taking advantage of synthetic electrochemistry, commercially available aldehydes (ketones) and benzylic alcohols can be readily arylated to provide a general and scalable access to structurally diverse alcohols (97 examples, >10 gram-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochemical technology, was employed to transform low-value alcohols into more useful alcohols. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral alpha-arylation of benzylic alcohols.

Welcome to talk about 120-14-9, If you have any questions, you can contact Zhang, S; Li, LJ; Li, JJ; Shi, JX; Xu, K; Gao, WC; Zong, LY; Li, GG; Findlater, M or send Email.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O in TAYLOR & FRANCIS LTD published article about CARBONIC-ANHYDRASE INHIBITORS; TROUT ONCORHYNCHUS-MYKISS; ERYTHROCYTE ISOZYMES I; CRYSTAL-STRUCTURE; ANTICHOLINERGIC ACTIVITIES; BIOLOGICAL EVALUATION; MEDICINAL CHEMISTRY; 1ST SYNTHESIS; HALOGEN BOND; ACETYLCHOLINESTERASE in [Burmaoglu, Serdar] Erzincan Binali Yildirim Univ, Tercan Vocat High Sch, TR-24800 Erzincan, Turkey; [Burmaoglu, Serdar; Yilmaz, Ali Osman; Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey; [Polat, M. Fatih] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Erzincan, Turkey; [Kaya, Ruya] Ibrahim Cecen Univ Agri, Cent Res & Applicat Lab, Agri, Turkey; [Algul, Oztekin] Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, Mersin, Turkey in 2021, Cited 86. Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some diseases. The compounds demonstrated K-i values between 13.6 +/- 1.1 and 50.0 +/- 17.1 nM on hCA I, 9.9 +/- 0.8 and 39.5 +/- 15.1 nM on hCA II, 3.1 +/- 0.2 and 20.1 +/- 1.9 nM on AChE, 4.9 +/- 0.4 and 14.7 +/- 5.2 nM on BChE and 3.9 +/- 0.2 and 22.4 +/- 10.7 nM on alpha-Gly enzymes. The results revealed that novel tris-chalcones can have promising drug potential for glaucoma, leukaemia, epilepsy; Alzheimer’s disease that was associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes.

Welcome to talk about 120-14-9, If you have any questions, you can contact Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O or send Email.. Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wang, D; Cao, FR; Lu, GY; Ren, JM; Zeng, BB in PERGAMON-ELSEVIER SCIENCE LTD published article about SOLVENT-FREE; CHEMOSELECTIVE ACETALIZATION; EFFICIENT CATALYST; HIGHLY EFFICIENT; ACID CATALYSTS; ALDEHYDES; ACETALS; MILD; KETALIZATION in [Wang, Di; Cao, Fu-Rong; Lu, Guangying; Ren, Jiangmeng; Zeng, Bu-Bing] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2021.0, Cited 72.0. Quality Control of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields. (c) 2021 Elsevier Ltd. All rights reserved.

Quality Control of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Wang, D; Cao, FR; Lu, GY; Ren, JM; Zeng, BB or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3,4-Dimethoxybenzaldehyde. Authors Ha, H; Choi, HJ; Park, H; Gwon, Y; Lee, J; Kwak, J; Kim, M; Jung, B in WILEY-V C H VERLAG GMBH published article about in [Ha, Hyeonbin; Choi, Ho Jeong; Kim, Min] Chungbuk Natl Univ, Dept Chem, Cheongju 28644, South Korea; [Park, Hahyoun; Gwon, Yunyeong; Lee, Jiin; Jung, Byunghyuck] Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Emerging Mat Sci, Daegu 42988, South Korea; [Kwak, Jaesung] Korea Res Inst Chem Technol KRICT, Infect Dis Therapeut Res Ctr, Daejeon 34114, South Korea in 2021.0, Cited 66.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The Pd-catalyzed gamma-position sp(3)-C-H arylation of primary amines bearing an aliphatic chain or cycloalkyl substituent and related mechanistic studies are disclosed. 3-Bromo-2-hydroxybenzaldehyde plays a key role in gamma-position sp(3)-C-H arylation as a transient directing group (TDG) to assist the regio- and stereoselective C-H activation of a Pd catalyst, and the development of a tandem reaction to transform 1 degrees-amines into gamma-aryl-substituted ketones demonstrates synthetic utility. Density functional theory (DFT)-based calculations revealed the detailed reaction mechanism and the origins of the high selectivity (gamma-position and cis-only). The X-ray crystal structure of the isolated endo-palladacycle intermediate supported the DFT results, and a kinetic isotope experiment confirmed the results of DFT calculations indicating that the C-H activation step via simultaneous palladation and deprotonation is rate-determining.

Quality Control of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Ha, H; Choi, HJ; Park, H; Gwon, Y; Lee, J; Kwak, J; Kim, M; Jung, B or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. Authors Shi, CZ; Li, FS; Chen, YQ; Lin, SJ; Hao, EJ; Guo, ZW; Wosqa, UT; Zhang, DD; Shi, L in AMER CHEMICAL SOC published article about in [Shi, Caizhe; Li, Fusheng; Chen, Yuqing; Lin, Shuangjie; Guo, Zhuowen; Wosqa, Urwa Tul; Zhang, Dandan; Shi, Lei] Dalian Univ Technol, Zhang Dayu Sch Chem, State Key Lab Fine Chem, Dalian 116024, Liaoning, Peoples R China; [Hao, Erjun; Shi, Lei] Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Key Lab Green Chem Media & React, Minist Educ,Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China in 2021.0, Cited 51.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The concept of umpolung reactivity of p-allylmetal complexes has been developed as a powerful method for the allylation of aldehydes. This paper describes the photocatalytic umpolung strategy for the synthesis of nucleophilic allylcobalt complexes through a single-electron-transfer (SET) process. This strategy enables the metallaphotoredox allylation of carbonyls with allyl acetate using organic N,N-diisopropylethylamine as the terminal reductant bypassing the use of a stoichiometric amount of metals. Ultraviolet-visible spectroscopy was used to monitor the redox changes of cobalt in the reaction.

Welcome to talk about 120-14-9, If you have any questions, you can contact Shi, CZ; Li, FS; Chen, YQ; Lin, SJ; Hao, EJ; Guo, ZW; Wosqa, UT; Zhang, DD; Shi, L or send Email.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles