Category: 1215205-77-8

Schendera, Eva et al. published their research in Chemistry – A European Journal in 2020 | CAS: 1215205-77-8

tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 1215205-77-8

Visible-Light-Mediated Aerobic Tandem Dehydrogenative Povarov/Aromatization Reaction: Synthesis of Isocryptolepines was written by Schendera, Eva;Unkel, Lisa-Natascha;Huyen Quyen, Phung Phan;Salkewitz, Gwen;Hoffmann, Frank;Villinger, Alexander;Brasholz, Malte. And the article was included in Chemistry – A European Journal in 2020.HPLC of Formula: 1215205-77-8 The following contents are mentioned in the article:

A metal-free, photoinduced aerobic tandem amine dehydrogenation/Povarov cyclization/aromatization reaction between N-aryl glycine esters and indoles leads to tetracyclic 11H-indolo[3,2-c]quinolines under mild conditions and with high yields. The reaction can be performed by using mol. iodine along with visible light, or by combining an organic photoredox catalyst with a halide anion. Mechanistic studies reveal that product formation occurs through a combination of radical-mediated oxidation steps with an iminium ion or N-haloiminium ion [4+2]-cycloaddition, and the N-heterocyclic products constitute new analogs of the antiplasmodial natural alkaloid isocryptolepine. Thus, e.g., reaction of N-(p-anisidinyl)glycine Et ester with N-Boc-indole in presence of I2 and O2 under blue light afforded indoloquinoline I (70%) in mixture with its deprotected derivative (22%). This study involved multiple reactions and reactants, such as tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8HPLC of Formula: 1215205-77-8).

tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 1215205-77-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liu, Kai et al. published their research in Chemical Science in 2018 | CAS: 1215205-77-8

tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate

Gold-catalyzed stereoselective dearomatization/metal-free aerobic oxidation: access to 3-substituted indolines/oxindoles was written by Liu, Kai;Xu, Guangyang;Sun, Jiangtao. And the article was included in Chemical Science in 2018.Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate The following contents are mentioned in the article:

An unprecedented dearomatization of indoles with diazoesters was developed via cationic gold(I) catalysis. The functionalization selectively occurred at the C3-position to deliver methylene indole derivatives in good yields with excellent Z-selectivity, demonstrating unusual reactivity and selectivity compared with other noble metal catalysis. Importantly, simply followed by silica gel adsorption, an unprecedented metal-free aerobic oxidation occurred for indoles bearing N-electron donating substituents, provided a novel and efficient approach towards 3-substituted indolin-2-ones with a newly formed quaternary stereocenter in excellent stereoselectivity. Notably, these processes afforded direct and selective access to a variety of valuable intermediates from abundant feedstock chems. This study involved multiple reactions and reactants, such as tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate).

tert-Butyl 7-methoxy-1H-indole-1-carboxylate (cas: 1215205-77-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of tert-Butyl 7-methoxy-1H-indole-1-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles