Category: 123-11-5

Authors Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD in ROYAL SOC CHEMISTRY published article about in [Paul, Avishek; Shipman, Michael A.; Onabule, Dolapo Y.; Sproules, Stephen; Symes, Mark D.] Univ Glasgow, Sch Chem, WestCHEM, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland in 2021, Cited 30. Application In Synthesis of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The enhancement of reactivity inside supramolecular coordination cages has many analogies to the mode of action of enzymes, and continues to inspire the design of new catalysts for a range of reactions. However, despite being a near-ubiquitous class of reactions in organic chemistry, enhancement of the reduction of carbonyls to their corresponding alcohols remains very much underexplored in supramolecular coordination cages. Herein, we show that encapsulation of small aromatic aldehydes inside a supramolecular coordination cage allows the reduction of these aldehydes with the mild reducing agent sodium cyanoborohydride to proceed with high selectivity (ketones and esters are not reduced) and in good yields. In the absence of the cage, low pH conditions are essential for any appreciable conversion of the aldehydes to the alcohols. In contrast, the specific microenvironment inside the cage allows this reaction to proceed in bulk solution that is pH-neutral, or even basic. We propose that the cage acts to stabilise the protonated oxocarbenium ion reaction intermediates (enhancing aldehyde reactivity) whilst simultaneously favouring the encapsulation and reduction of smaller aldehydes (which fit more easily inside the cage). Such dual action (enhancement of reactivity and size-selectivity) is reminiscent of the mode of operation of natural enzymes and highlights the tremendous promise of cage architectures as selective catalysts.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD or concate me.. Application In Synthesis of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A green approach for aerobic oxidation of benzylic alcohols catalysed by Cu-I-Y zeolite/TEMPO in ethanol without additional additives WOS:000609189100025 published article about SELECTIVE OXIDATION; HIGHLY EFFICIENT; COPPER NANOPARTICLES; GALACTOSE-OXIDASE; GRAPHENE OXIDE; COMPLEXES; LIGAND; CONVERSION; CHEMISTRY; SYSTEM in [Senthilkumar, Samuthirarajan; Zhong, Wei; Natarajan, Mookan; Lu, Chunxin; Liu, Xiaoming] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing, Zhejiang, Peoples R China; [Xu, Binyu] Nanchang Univ, Sch Chem, Nanchang, Jiangxi, Peoples R China in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Quality Control of 4-Methoxybenzaldehyde

An efficient and green protocol for aerobic oxidation of benzylic alcohols in ethanol using Cu-I-Y zeolite catalysts assisted by TEMPO (TEMPO = 2,2,6,6-tetramethyl-1-piperidine-N-oxyl) as the radical co-catalyst in the presence of atmospheric air under mild conditions is reported. The Cu-I-Y zeolite prepared via ion exchange between CuCl and HY zeolite was fully characterized by a variety of spectroscopic techniques including XRD, XPS, SEM, EDX and HRTEM. The incorporation of Cu(i) into the 3D-framework of the zeolite rendered the catalyst with good durability. The results of repetitive runs revealed that in the first three runs, there was hardly a decline in activity and a more substantial decrease in yield was observed afterwards, while the selectivity remained almost unchanged. The loss in activity was attributed to both the formation of CuO and the bleaching of copper into the liquid phase during the catalysis, of which the formation of CuO was believed to be the major contributor since the bleaching loss for each run was negligible (<2%). In this catalytic system, except TEMPO, no other additives were needed, either a base or a ligand, which was essential in some reported catalytic systems for the oxidation of alcohols. The aerobic oxidation proceeded under mild conditions (60 degrees C, and 18 hours) to quantitatively and selectively convert a wide range of benzylic alcohols to corresponding aldehydes, which shows great potential in developing green and environmentally benign catalysts for aerobic oxidation of alcohols. The system demonstrated excellent tolerance against electron-withdrawing groups on the phenyl ring of the alcohols and showed sensitivity to steric hindrance of the substrates, which is due to the confinement of the pores of the zeolite in which the oxidation occurred. Based on the mechanism reported in the literature for homogenous oxidation, a mechanism was analogously proposed for the aerobic oxidation of benzylic alcohols catalysed by this Cu(i)-containing zeolite catalyst. Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Senthilkumar, S; Zhong, W; Natarajan, M; Lu, CX; Xu, BY; Liu, XM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Mechanistic Studies on Photoinduced Catalytic Olefin Migration Reactions at the Pd(II) Centers of a Porous Crystal, Metal-Macrocycle Framework WOS:000600657000001 published article about ORGANIC FRAMEWORKS; HYDROGEN STORAGE; ISOMERIZATION; DIMERIZATION; ADSORPTION; ETHYLENE in [Yonezawa, Hirotaka; Han, Mengying; Tashiro, Shohei; Shionoya, Mitsuhiko] Univ Tokyo, Grad Sch Sci, Dept Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; [Shiraogawa, Takafumi; Ehara, Masahiro] Inst Mol Sci, Okazaki, Aichi 4448585, Japan; [Shiraogawa, Takafumi; Ehara, Masahiro] SOKENDAI, Okazaki, Aichi 4448585, Japan in 2021.0, Cited 47.0. SDS of cas: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Porous crystals with well-defined active metal centers on the pore surface have high potential as heterogeneous metal catalysts. We have recently demonstrated that a porous molecular crystal, metal-macrocycle framework (MMF), catalyzes olefin migration reactions by photoactivation of its (PdCl2)-Cl-II moieties exposed on the crystalline channel surface. Herein we report a mechanistic study of the photoinduced olefin migration reactions at the Pd-II active centers of MMF. Several experiments, including a deuterium scrambling study, revealed that olefin migration is catalyzed via an alkyl mechanism by in situ generated Pd-H species on the channel surface during photoirradiation. This proposed mechanism was further supported by DFT and ONIOM calculations.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yonezawa, H; Shiraogawa, T; Han, MY; Tashiro, S; Ehara, M; Shionoya, M or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A regioselective [4+2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines WOS:000659907800001 published article about BIOLOGICAL EVALUATION; CHEMICAL SPACE; INDOLIZINES; DERIVATIVES; INHIBITORS; CASCADE; YLIDES in [Kim, Sunmi; Lee, Jeong Hwa; Kim, Ikyon] Yonsei Univ, Coll Pharm, 85 Songdogwahak Ro, Incheon 21983, South Korea; [Kim, Sunmi; Lee, Jeong Hwa; Kim, Ikyon] Yonsei Univ, Yonsei Inst Pharmaceut Sci, 85 Songdogwahak Ro, Incheon 21983, South Korea; [Yoon, Seok Hyun] Yonsei Univ, Grad Program Ind Pharmaceut Sci, 85 Songdogwahak Ro, Incheon 21983, South Korea in 2021, Cited 46. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The reaction of beta-ketonitrile and N-substituted pyrrole-2-carboxaldehyde in the presence of piperidinium acetate in CH3CN permitted regioselective access to 5-acylindolizine-7-carbonitrile through a domino Knoevenagel condensation-intramolecular aldol cyclization sequence. A wide range of new indolizine derivatives with a poly-functionalized pyridine moiety were readily synthesized in an atom-economical fashion, thereby expanding the indolizine chemical space for further applications.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kim, S; Lee, JH; Yoon, SH; Kim, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Venugopala, KN; Deb, PK; Pillay, M; Chopra, D; Chandrashekharappa, S; Morsy, MA; Aldhubiab, BE; Attimarad, M; Nair, AB; Sreeharsha, N; Kandeel, M; Venugopala, R; Mohanlall, V in [Venugopala, Katharigatta N.; Morsy, Mohamed A.; Aldhubiab, Bandar E.; Attimarad, Mahesh; Nair, Anroop B.; Sreeharsha, Nagaraja] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi Arabia; [Venugopala, Katharigatta N.; Mohanlall, Viresh] Durban Univ Technol, Dept Biotechnol & Food Technol, ZA-4001 Durban, South Africa; [Deb, Pran Kishore] Philadelphia Univ, Fac Pharm, Dept Pharmaceut Sci, Amman 19392, Jordan; [Pillay, Melendhran] Inkosi Albert Luthuli Cent Hosp, Dept Microbiol, Natl Hlth Lab Serv, KZN Acad Complex, ZA-4001 Durban, South Africa; [Chopra, Deepak] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal By Pass Rd, Bhopal 462066, Madhya Pradesh, India; [Chandrashekharappa, Sandeep] GKVK, Inst Stem Cell Biol & Regenerat Med, TIFR, NCBS, Bangalore 560065, Karnataka, India; [Morsy, Mohamed A.] Menia Univ, Fac Med, Dept Pharmacol, El Minia 61511, Egypt; [Sreeharsha, Nagaraja] Vidya Siri Coll Pharm, Dept Pharmaceut, Off Sarjapura Rd, Bengaluru 560035, India; [Kandeel, Mahmoud] King Faisal Univ, Coll Vet Medi Cine, Dept Biomed Sci, Al Hasa 31982, Saudi Arabia; [Kandeel, Mahmoud] Kafrelsheikh Univ, Fac Vet Med, Dept Pharmacol, Kafrelsheikh 33516, Egypt; [Venugopala, Rashmi] Univ KwaZulu Natal, Dept Publ Hlth Med, Howard Coll Campus, ZA-4001 Durban, South Africa published 4-Aryl-1,4-Dihydropyridines as Potential Enoyl-Acyl Carrier Protein Reductase Inhibitors: Antitubercular Activity and Molecular Docking Study in 2021, Cited 93. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Background: Tuberculosis remains one of the most deadly infectious diseases worldwide due to the emergence of multi-drug resistance (MDR) and extensively drug resistance (XDR) strains of Mycobacterium tuberculosis (MTB). Aims: Currently, available drugs are getting resistant and toxic. Hence, there is an urgent need for the development of potent molecules to treat tuberculosis. Materials and Methods: Herein, the screening of a total of eight symmetrical 1,4-dihydropyridine (1,4-DHP) derivatives (4a-4h) was carried out for whole-cell anti-TB activity against the susceptible H37Rv and MDR strains of MTB. Results and Discussion: Most of the compounds exhibited moderate to excellent activity against the susceptible H37Rv. Moreover, the most promising compound 4f (against H37Rv) having para-trifluoromethyl phenyl group at 4-position and bis para-methoxy benzyl ester group at 3- and 5-positions of 1,4- dihydropyridine pharmacophore, exhibited no toxicity, but demonstrated weak activity against MTB strains resistant to isoniazid and rifampicin. In light of the inhibitory profile of the title compounds, enoyl-acyl carrier protein reductase (InhA) appeared to be the appropriate molecular target. A docking study of these derivatives against InhA receptor revealed favorable binding interactions. Further, in silico predicted ADME properties of these compounds 4a-4h were found to be in the acceptable ranges, including satisfactory Lipinski’s rule of five, thereby indicating their potential as drug-like molecules. Conclusion: In particular, the 1,4-DHP derivative 4f can be considered an attractive lead molecule for further exploration and development of more potent anti-TB agents as InhA inhibitors.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Venugopala, KN; Deb, PK; Pillay, M; Chopra, D; Chandrashekharappa, S; Morsy, MA; Aldhubiab, BE; Attimarad, M; Nair, AB; Sreeharsha, N; Kandeel, M; Venugopala, R; Mohanlall, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. Authors Ali, S; Khan, A in ROYAL SOC CHEMISTRY published article about in [Ali, Saghir; Khan, Abu T.] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India in 2021, Cited 17. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An efficient and expedient synthetic protocol is reported for the synthesis of 2,3-diarylquinoline derivatives from readily available aryl amines, aryl aldehydes and styrene oxides using 10 mol% copper(ii) triflate by employing three-component reaction. This approach involves the reaction between the in situ generated imine (derived from the aryl amine and aryl aldehyde) and styrene oxide, which enables the formation of the desired products. The present method has several advantages such as high atom-economy, high regioselectivity, easy handling, consecutive one C-N and two C-C bond formation, shorter reaction time and broader substrate scope with good yields.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ali, S; Khan, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Multicomponent synthesis of novel 3-benzoyl-4h-benzo[g]chromene-5,10-dione derivatives WOS:000662212800020 published article about CATALYZED SYNTHESIS; ONE-POT; GREEN in [Giang Le-Nhat-Thuy; Tuyet Anh Dang Thi; Phuong Hoang Thi; Quynh Giang Nguyen Thi; Ha-Thanh Nguyen; Tuan-Anh Nguyen; Tuyen Van Nguyen] Vietnam Acad Sci & Technol VAST, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Giang Le-Nhat-Thuy; Tuyet Anh Dang Thi; Quynh Giang Nguyen Thi; Ha-Thanh Nguyen; Tuyen Van Nguyen] Grad Univ Sci & Technol, VAST, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Doan Vu Ngoc] Le Quy Don Tech Univ, 236 Hoang Quoc Viet, Hanoi, Vietnam in 2021, Cited 29. Category: indole-building-block. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An efficient method was developed to prepare a series of novel 3-benzoyl-4H-benzo[g]chromene-5,10-dione derivatives from 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and arylenaminones in glacial acetic acid under microwave irradiation. This transformation presumably occurs via a Knoevenagel condensation – dehydration – Michael addition – O-cyclization – proton transfer – elimination – deprotonation – double bond isomerization sequence of reactions. (C) 2021 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Le-Nhat-Thuy, G; Thi, TAD; Thi, PH; Thi, QGN; Nguyen, HT; Ngoc, DV; Nguyen, TA; Van Nguyen, T or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2021.0 STRUCT CHEM published article about IN-VITRO CYTOTOXICITY; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; DESIGN; PHOTOPHYSICS; DIIMIDE; AGENTS; ASSAY in [Lakshmanan, Sivalingam; Mahalakshmi, K.; Thirumurugan, K.; Ramalakshmi, N.; Antony, S. Arul] Presidency Coll, Dept Chem, Chennai 600005, Tamil Nadu, India; [Lakshmanan, Sivalingam] Bharath Univ, BIHER, Dept Chem, Chennai 600073, Tamil Nadu, India; [Govindaraj, Dharman] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India in 2021.0, Cited 60.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Chalcone derivatives (7a-k) have been synthesized and characterized by H-1-NMR, C-13-NMR, mass, and elemental analysis. The synthesized compounds 7a, 7d, and 7g have been examined and it is confirmed that the most promising cytotoxicity and also cell morphology analysis exhibited good apoptotic activity against lung cancer A549 cell. The free energy binding of compound 7d exhibits – 8.96 kcal/mol with five hydrogen bonding Asn1254, Arg1253, Asp1249, and Gly1123 amino acids of ALK receptors. The LUMO of the electron density present in alpha, beta-double bond and influence the anticancer activity. The Mulliken atomic charges and MEPs are scrutinizing the ligand interaction with the amino acid binding of ALK receptors. UV-visible and photoluminescence spectra showed that the properties of chalcone derivatives have a significant effect on the visible absorption and emission maxima (531-535 nm) red shift in the emission spectra which also systematically investigated electrochemical in various solvents with increasing solvent polarity.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Lakshmanan, S; Govindaraj, D; Mahalakshmi, K; Thirumurugan, K; Ramalakshmi, N; Antony, SA or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, biological activity, molecular docking studies of a novel series of 3-Aryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the acetylcholinesterase inhibitors WOS:000527166800001 published article about MITOCHONDRIAL DYSFUNCTION; DESIGN; COMPLEX; DISCOVERY; AGENTS in [Jin, Zhe; Zhang, Chao; Liu, Miao; Jiao, Simeng; Zhao, Jing; Liu, Xiaoping; Hu, Chun] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Lin, Huangquan; Wan, David Chi-cheong] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Hong Kong, Peoples R China in 2021, Cited 48. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Product Details of 123-11-5

The acetylcholinesterase inhibitors play a critical role in the drug therapy for Alzheimer’s disease. In this study, twenty-nine novel 3-aryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were synthesized and assayed for their human acetylcholinesterase (hAChE) inhibitory activities. Inhibitory ratio values of seventeen compounds were above 55% with 4c having the highest value as 77.19%. The compounds with the halogen atoms in the aromatic ring, and N,N-diethylamino or N,N-dimethylamino groups in the side chains at C-3 positions exhibited good inhibitory activity. SAR study was carried out by means of molecular docking technique. According to molecular docking results, the common interacting site for all compounds were found to be peripheral anionic site whereas highly active compounds were interacting with the catalytic active site too.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Jin, Z; Zhang, C; Liu, M; Jiao, SM; Zhao, J; Liu, XP; Lin, HQ; Wan, DCC; Hu, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Cho, HJ; Kim, KS; Kim, H; Kim, T; Malyutin, AG; Rees, DC; Yoo, BK; Song, C in AMER CHEMICAL SOC published article about in [Cho, Hye Jin; Kim, Kyung-su; Kim, Hyunwoo; Kim, Taewoo; Song, Changsik] Sungkyunkwan Univ, Dept Chem, Suwon 16419, Gyeonggi Do, South Korea; [Malyutin, Andrey G.] CALTECH, Beckman Inst, Pasadena, CA 91125 USA; [Rees, Douglas C.; Yoo, Byung-Kuk] CALTECH, Dept Chem & Chem Engn, Pasadena, CA 91125 USA; [Rees, Douglas C.; Yoo, Byung-Kuk] CALTECH, HHMI, Pasadena, CA 91125 USA in 2021, Cited 62. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Aggregation-induced emission (AIE) phenomena have gained intense interest over the last decades because of its importance in solid-state emission. However, the elucidation of a working mechanism is difficult owing to the limited characterization methods on solid-state molecules, further complicated if dynamic structural changes occur. Here, a series of bis-arylacylhydrazones (BAHs) were synthesized, for which their AIE properties are only turned on by the reversible adsorption of water molecules. We used microcrystal electron diffraction (MicroED) to determine the molecular structures of two BAHs directly from bulk powders (without attempting to grow crystals) prepared in the absence or presence of water adsorption. This study reveals the unambiguous characterization of the dependence of crystal packing on the specific cocrystallization with hydrates. The structural analysis demonstrates that water molecules form strong hydrogen bonds with three neighboring BAH-1, resulting in the almost complete planarization and restriction of the intramolecular rotation of the molecule. MicroED plays an important role in providing a decisive clue for the reversible polymorphism changes induced by the adsorption of water molecules, regulating emissive properties.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Cho, HJ; Kim, KS; Kim, H; Kim, T; Malyutin, AG; Rees, DC; Yoo, BK; Song, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles