Fassbender, Svenja I. published the artcileGeometric E→Z Isomerisation of Alkenyl Silanes by Selective Energy Transfer Catalysis: Stereodivergent Synthesis of Triarylethylenes via a Formal anti-Metallometallation, Category: indole-building-block, the publication is Angewandte Chemie, International Edition (2019), 58(51), 18619-18626, database is CAplus and MEDLINE.
An efficient geometrical E→Z isomerization of alkenyl silanes is disclosed via selective energy transfer using an inexpensive organic sensitizer. Characterized by operational simplicity, short reaction times (2 h), and broad substrate tolerance, the reaction displays high selectivity for trisubstituted systems (Z/E up to 95:5). In contrast to thermal activation, directionality results from deconjugation of the π-system in the Z-isomer due to A1,3-strain thereby inhibiting re-activation. The structural importance of the β-substituent logically prompted a study of mixed bis-nucleophiles (Si, Sn, B). These versatile linchpins also undergo facile isomerization, thereby enabling a formal anti-metallometalation. Mechanistic interrogation, supported by a theor. study, is disclosed together with application of the products to the stereospecific synthesis of biol. relevant target structures.
Angewandte Chemie, International Edition published new progress about 1256359-23-5. 1256359-23-5 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Sulfamide,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 1-(Phenylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, and the molecular formula is C20H22BNO4S, Category: indole-building-block.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles