Category: 127-07-1

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.127-07-1, Name is Hydroxyurea, SMILES is O=C(N)NO, belongs to indole-building-block compound. In a document, author is Zhang, Xuwang, introduce the new discover, Formula: https://www.ambeed.com/products/127-07-1.html.

BACKGROUND Indole, an important type of N-heterocyclic aromatic compound, is considered a toxic and odorous pollutant in coking and municipal wastewater. For efficient bioremediation of indole-containing wastewater, an indole-degrading bacterial strain JW was isolated from activated sludge in this study. The indole biodegradation characteristics and the whole-genome sequence of strain JW were also determined. RESULTS Strain JW, capable of utilizing indole as the sole carbon and nitrogen source, was identified as Acinetobacter sp. based on 16S rRNA gene sequence analysis. It was able to completely degrade 100 mg L-1 indole within 20 h, and transform organic nitrogen to ammonia (NH4+-N) and nitrate (NO3–N). Meanwhile, strain JW also presented high capacity for indole degradation at a range of initial indole concentrations (25-200 mg L-1) and pH (6.0-8.0). The key metabolites during indole biodegradation were identified by liquid chromatography coupled to Q-Exactive high resolution mass spectrometry, and included isatin, anthranilate, salicylate, catechol and indigo. The whole-genome sequence of strain JW revealed the possible functional genes related to indole biodegradation, such as iif genes, ant genes and downstream metabolic genes. Thus, an indole biodegradation mechanism was proposed based on metabolites identification and genomic analysis. CONCLUSION The results suggested that Acinetobacter sp. JW could be a promising biological candidate for bioremediation of indole, and the useful genetic information might enrich our understanding of microbial degradation of indole. (c) 2018 Society of Chemical Industry

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 127-07-1 is helpful to your research. Formula: https://www.ambeed.com/products/127-07-1.html.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In an article, author is Pan, Jiaoting, once mentioned the application of 127-07-1, Product Details of 127-07-1, Name is Hydroxyurea, molecular formula is CH4N2O2, molecular weight is 76.05, MDL number is MFCD00007943, category is indole-building-block. Now introduce a scientific discovery about this category.

The first facile and efficient acid-catalyzed three-component reaction of indoles, H-phosphine oxides and carbonyl compounds has been developed, providing a general, one-pot approach to structurally diverse C3-alkylated indole derivatives accompanied by concurrent C-P/C-C bond formation with remarkable functional group tolerance and excellent regioselectivity.

If you are interested in 127-07-1, you can contact me at any time and look forward to more communication. Product Details of 127-07-1.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In an article, author is Youn, So Won, once mentioned the application of 127-07-1, Name is Hydroxyurea, molecular formula is CH4N2O2, molecular weight is 76.05, MDL number is MFCD00007943, category is indole-building-block. Now introduce a scientific discovery about this category, Computed Properties of CH4N2O2.

Metal-Catalyzed Synthesis of Substituted Indoles

Indoles are important structural motifs that are commonly found in a diverse array of natural products, pharmaceuticals, and other functional molecules. Consequently, the development of new, more efficient synthetic methods for the construction of substituted indoles continues to be of great importance and considerable interest. Over the past few decades, metal-catalyzed C-C/C-N bond-forming reactions have emerged as a powerful synthetic strategy for heterocyclic synthesis. In this review, we have provided a brief overview of recent advances in the metal-catalyzed synthesis of substituted indoles through the construction of the pyrrole nucleus of indoles, involving the formation of multiple C-C/C-N bonds.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles