Category: 132098-59-0

Synthetic Route of C19H18N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology. Author is Marichev, Kostiantyn O.; Takacs, James M..

A new ruthenium complex catalyzes the amination of primary and secondary alcs. and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermol. cyclizations of aminoalcs., diols, and diamines lead to heterocyclic ring systems.

When you point to this article, it is believed that you are also very interested in this compound(132098-59-0)Synthetic Route of C19H18N2O2 and due to space limitations, I can only present the most important information.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane(SMILESS: C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1,cas:132098-59-0) is researched.Quality Control of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine. The article 《Catalytic activity of copper-bis(oxazoline) grafted on mesoporous silica in enantioselective cyclopropanation》 in relation to this compound, is published in Reaction Kinetics, Mechanisms and Catalysis. Let’s take a look at the latest research on this compound (cas:132098-59-0).

Chiral Ph substituted bis(oxazoline) (PhBox) was covalently immobilized through carbamate linkers onto mesoporous silica materials. These supports were previously prepared by the sol-gel method and they exhibited different textural properties. The presence and the integrity of the bis(oxazoline) ligand was checked by 13C-CP-MAS-NMR. These chiral mesoporous materials were complexed with copper(II) triflate. In spite of the different textural properties of these supports, the copper loading, determined by ICP-AES, was nearly the same (0.041-0.044 mmol Cu/g of solid). The supported Cu(II) complexes were tested as catalysts in the enantioselective cyclopropanation of styrene with Et diazoacetate. Enantioselectivities were consistently lower than those obtained in homogeneous phase. Different analyses point to a difficulty in the formation of the expected chelate, due to the presence of a coordinating functional group in the linker, as responsible for the loss in enantioselectivity. The textural properties of the materials significantly affected the behavior upon recovery.

As far as I know, this compound(132098-59-0)Quality Control of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane(SMILESS: C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1,cas:132098-59-0) is researched.Product Details of 1008-89-5. The article 《Copper(II)-Catalyzed Asymmetric Photoredox Reactions: Enantioselective Alkylation of Imines Driven by Visible Light》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:132098-59-0).

Copper(II) bis(oxazoline) complexes generated in situ from Cu(BF4)2 and nonracemic bisoxazolines acted as photoredox catalysts in the absence of other sensitizers for enantioselective alkylation reactions of imines such as dioxobenzoisothiazolecarboxylate I and N-Boc imino oxindoles with aralkyltrifluoroborates to yield nonracemic α-amino esters such as benzisothiazolidinecarboxylate II and benzylic oxindoles such as III. The copper-bisoxazoline catalysts both initiated radical generation and governed subsequent stereoselective transformations. The mechanism of the reactions was studied by trapping of radical intermediates, UV/visible spectra and reduction potentials of reactants, intermediates, and catalysts formed in the reactions, and the crystal structure of a dimeric copper bis(oxazoline) catalyst potentially generated under the reaction conditions.

This literature about this compound(132098-59-0)Recommanded Product: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methanehas given us a lot of inspiration, and I hope that the research on this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Silva, Ana Rosa; Carneiro, Liliana; Carvalho, Ana P.; Pires, Joao researched the compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane( cas:132098-59-0 ).Electric Literature of C19H18N2O2.They published the article 《Asymmetric benzoylation of hydrobenzoin by copper(II) bis(oxazoline) anchored onto ordered mesoporous silicas and their carbon replicas》 about this compound( cas:132098-59-0 ) in Catalysis Science & Technology. Keywords: asym benzoylation hydrobenzoin copper oxazoline complex silica carbon replica. We’ll tell you more about this compound (cas:132098-59-0).

A copper(ii) complex with a com. chiral bis(oxazoline) was anchored onto ordered mesoporous silica materials and their resp. carbon replicas. The amount of transition metal complex loaded onto the mesostructured solids was determined by ICP-AES and the materials were also characterized by elemental anal., FTIR, TG/DSC and isotherms of N2 adsorption at -196 °C. For the first time the asym. benzoylation of a 1,2-diol was performed in the heterogeneous phase by using an anchored com. bis(oxazoline) ligand. The effect of the type of mesoporous material on the catalytic parameters, as well as on the reutilization of catalysts in several catalytic cycles, was checked. All the composites prepared were active, selective and enantioselective in this asym. organic transformation. Using the two ordered mesoporous silicas as supports good selectivities, with comparable yields and TONs to the homogeneous phase reaction, were obtained. Furthermore these two heterogeneous catalysts are more stable upon reuse than the corresponding ordered carbon replica materials. One of the former heterogeneous catalysts, with mesoporous silica as a support, could be further reused for 4 consecutive cycles without significant loss of selectivity, the TON or enantioselectivity.

This literature about this compound(132098-59-0)Electric Literature of C19H18N2O2has given us a lot of inspiration, and I hope that the research on this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 132098-59-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Asymmetric synthesis of the dopamine D1 agonist, dihydrexidine. Author is Hajra, Saumen; Bar, Sukanta.

A concise asym. synthesis of first, high affinity Domaine D1 full agonist, dihydrexidine has been accomplished via catalytic enantioselective aziridination and subsequent one-pot Friedel-Crafts cyclization of an in situ generated tethered aziridine with high diastereo- and enantioselectivities.

This literature about this compound(132098-59-0)Product Details of 132098-59-0has given us a lot of inspiration, and I hope that the research on this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nielsen, Daniel K.; Nielsen, Laura L.; Jones, Spencer B.; Toll, Lawrence; Asplund, Matthew C.; Castle, Steven L. researched the compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane( cas:132098-59-0 ).Name: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane.They published the article 《Synthesis of Isohasubanan Alkaloids via Enantioselective Ketone Allylation and Discovery of an Unexpected Rearrangement》 about this compound( cas:132098-59-0 ) in Journal of Organic Chemistry. Keywords: hasubanan alkaloid asym synthesis stereoselective ketone allylation; pinacol rearrangement hasubanan alkaloid asym synthesis; isohasubanan alkaloid asym synthesis stereoselective ketone allylation; analgesic activity isohasubanan alkaloid asym synthesis. We’ll tell you more about this compound (cas:132098-59-0).

A synthesis of the hasubanan alkaloids hasubanonine, runanine, and aknadinine via a unified route was attempted. Construction of key phenanthrene intermediates by a Suzuki coupling-Wittig olefination-ring-closing metathesis sequence allowed a convergent and flexible approach. Conversion of the phenanthrenes into the target structures was projected to involve six steps including phenolic oxidation, ketone allylation, anionic oxy-Cope rearrangement, and acid-promoted cyclization. The final step was thwarted by a pinacol-like rearrangement that delivered the unnatural isohasubanan alkaloid skeleton. The structures of the products were established by exhaustive NMR experiments and confirmed by GIAO 13C NMR calculations of runanine, isorunanine, and three other isomers. These computations revealed some inconsistencies with the benzene solvent correction which suggest that caution should be used in employing this algorithm. The previously reported synthesis of (±)-isohasubanonine was transformed into an enantioselective synthesis of (-)-isohasubanonine (I) by the discovery that Nakamura’s chiral bisoxazoline-ligated allylzinc reagent mediates the enantioselective allylation of ketone II in 93% ee. This method could be extended to three other structurally related ketones (92-96% ee), and the enantioselective syntheses of two other isohasubanan alkaloids, isorunanine and isoaknadinine, were accomplished. (±)-Isohasubanonine was found to be an ineffective analgesic agent.

In addition to the literature in the link below, there is a lot of literature about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Name: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, illustrating the importance and wide applicability of this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Grell, Yvonne; Xie, Xiulan; Ivlev, Sergei I.; Meggers, Eric published the article 《Enantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by a Non-C2-Symmetric Chiral-at-Rhodium Catalyst》. Keywords: chiral rhodium catalyst preparation; fluorinated alpha chlorinated acyl pyrazole enantioselective preparation; acyl pyrazole chiral rhodium catalyst fluorination chlorination.They researched the compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane( cas:132098-59-0 ).Related Products of 132098-59-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:132098-59-0) here.

A non-C2-sym. and sterically demanding chiral-at-rhodium catalyst was demonstrated to efficiently catalyze the highly enantioselective α-fluorination [up to >99% enantiomeric excess (ee)] and α-chlorination (up to 98% ee) of N-acyl pyrazoles to afford α-fluorinated/chlorinated N-acyl pyrazoles I [R = Pr, Ph, 3-thienyl, ets.; R1 = F, Cl] in high yields. Based on two sterically distinct cyclometalating ligands, the nonracemic rhodium(III) catalyst could conveniently be accessed in an enantiomerically pure fashion (>99% ee) via an established auxiliary-mediated approach. Comparison of the catalytic performance with the related C2-sym. rhodium catalysts revealed the explicit superiority of the non-C2-sym. design for the presented α-halogenation reactions, which were generally featured by a very simple synthetic protocol.

In addition to the literature in the link below, there is a lot of literature about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Related Products of 132098-59-0, illustrating the importance and wide applicability of this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reference of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enantioselective propargylic oxidation. Author is Clark, J. Stephen; Tolhurst, Keith F.; Taylor, Mark; Swallow, Steven.

Benzoyl esters of propargylic alcs., RCCCHR1O2Ph (R = H, Me, Et, Ph, Me3Si; R1 = Me, Et, propyl) can be prepared in an enantioselective manner by direct copper-catalyzed acyloxylation of alkynes RCCCH2R1 with PhCO2OCMe3. High product yields and reasonable levels of induction are obtained upon the oxidation of non-terminal alkynes with excess perester using copper-bisoxazoline complexes as catalysts.

In addition to the literature in the link below, there is a lot of literature about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Reference of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, illustrating the importance and wide applicability of this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – A European Journal called Copper Bis(oxazoline)-Catalyzed Enantioselective Alkynylation of Benzopyrylium Ions, Author is Guan, Yong; Attard, Jonathan W.; Mattson, Anita E., which mentions a compound: 132098-59-0, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2, Electric Literature of C19H18N2O2.

The stereocontrolled construction of biol. relevant chromanones and tetrahydroxanthones were achieved through the addition of alkynes to benzopyrylium trilfates under the influence of copper bis(oxazoline) catalysis. Excellent levels of enantiocontrol (63-98% ee) were achieved in the addition of a variety of alkynes to an array of chromenones with a hydrogen in the 2-position. Promising levels of enantiocontrol (54-67% ee) were achieved in the alkynylation of chromenones with esters in the 2-position, generating tertiary ether stereocenters resembling those frequently found in naturally occurring metabolites.

In addition to the literature in the link below, there is a lot of literature about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Electric Literature of C19H18N2O2, illustrating the importance and wide applicability of this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Scope and limitations of chiral bis(oxazoline) ligands in the copper-catalysed asymmetric cyclopropanation of trisubstituted alkenes. Author is Ostergaard, N.; Jensen, J. F.; Tanner, D..

A series of derivatives of 3-methyl-2-buten-1-ol, Me2C:CHCH2OR (R = Ac, PhCH2, 4-O2NC6H4CO, etc.), has been used to test the scope and limitations of the copper-catalyzed asym. cyclopropanation of trisubstituted alkenes by Et diazoacetate in the presence of C2-sym. bis(oxazoline) ligands. In the best case, a trans/cis ratio of 91:9, with 92% ee for the major isomer, was obtained from the reaction of the p-methoxybenzoate derivative The highest ee was 95%, for the trans isomer of a 80:20 diastereomer mixture (acetate derivative).

In addition to the literature in the link below, there is a lot of literature about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Application In Synthesis of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, illustrating the importance and wide applicability of this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles