Category: 132098-59-0

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Asymmetric Construction of Quaternary Carbon Centers by Regio- and Enantiocontrolled Allylzincation, Author is Nakamura, Masaharu; Inoue, Toshihiro; Sato, Akihito; Nakamura, Eiichi, which mentions a compound: 132098-59-0, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2, Category: indole-building-block.

An allylic zinc reagent bearing a chiral bisoxazoline ligand adds to a substituted cyclopropenone acetal to produce an optically active cyclopropanone acetal possessing a quaternary chiral center in high yield with 97.8-99.8% ee. For example, the allylzincation of 1-ethyl-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene in the presence of a complex formed from (4S,4’S)-2,2′-methylenebis[4,5-dihydro-4-phenyloxazole] and bromo(2-propenyl)zinc gave (1R)-1-ethyl-6,6-dimethyl-1-(2-propenyl)-4,8-dioxaspiro[2.5]octane in high enantiomeric excess. The steric effects of the bulky bisoxazoline ligand overwhelm the regioselectivity inherent to the electronic property of the olefinic acceptor. High pressure exerts favorable effects on the reaction rate without affecting the high enantioselectivity or regioselectivity.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application of 132098-59-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Catalytic heterogeneous aziridination of alkenes using microporous materials. Author is Langham, Christopher; Piaggio, Paola; McMorn, Paul; Willock, David J.; Hutchings, Graham J.; Langham, Christopher; Bethell, Donald; Lee, Darren F.; Hutchings, Graham J.; Page, Philip C. Bulman; Sly, Chris; Hancock, Frederick E.; King, Frank.

Copper-exchanged zeolite Y is a highly active catalyst for the aziridination of alkenes (e.g., styrene) to aziridines (e.g., phenylaziridine); modification using bis(oxazolines) leads to preparation of the first heterogeneous enantioselective aziridination catalyst.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enoldiazosulfones for Highly Enantioselective [3 + 3]-Cycloaddition with Nitrones Catalyzed by Copper(I) with Chiral BOX Ligands.

Enoldiazosulfones undergo [3 + 3]-cycloaddition with nitrones when catalyzed by copper(I) catalysts, but not with dirhodium(II) catalysts. Under mild reaction conditions with chiral bisoxazoline ligands, copper(I) catalysts produce 1,2-oxazine-sulfone derivatives in high yields and enantioselectivities. Dirhodium(II) catalysts form stable donor-acceptor cyclopropenes that undergo uncatalyzed [3 + 2]-cycloaddition reactions with nitrones.

From this literature《Enoldiazosulfones for Highly Enantioselective [3 + 3]-Cycloaddition with Nitrones Catalyzed by Copper(I) with Chiral BOX Ligands》,we know some information about this compound(132098-59-0)Category: indole-building-block, but this is not all information, there are many literatures related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Related Products of 132098-59-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Iron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes. Author is Tyrol, Chet C.; Yone, Nang S.; Gallin, Connor F.; Byers, Jeffery A..

The first stereoconvergent Suzuki-Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes I [R = Me, Et, i-Pr, etc.; R1 = Ph, 4-FC6H4, 1-naphthyl, etc.; R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.]. An iron-based complex containing a chiral cyanobis(oxazoline) ligand framework was best to obtain enantioenriched 1,1-diarylalkanes from cross-coupling reactions between unactivated aryl boronic esters and benzylic chlorides. Enhanced yields were obtained when 1,3,5-trimethoxybenzene was used as an additive, which was hypothesized to extend the lifetime of the iron-based catalyst. Exceptional enantioselectivities were obtained with challenging ortho-substituted benzylic chlorides.

From this literature《Iron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes》,we know some information about this compound(132098-59-0)Related Products of 132098-59-0, but this is not all information, there are many literatures related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C19H18N2O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enantiotopic Differentiation of pro-R or pro-S Chlorides in (Dichloromethyl)borates by Chiral Lewis Acids: Enantioselective Synthesis of (α-Chloroalkyl)boronates. Author is Jadhav, Prabhakar K.; Man, Hon-Wah.

The 1,2-migration reaction of an alkyl group in borate complexes, I (e.g. R = Bu), derived from dichloromethyl pinacol boronates and alkyllithium was catalyzed by chiral Lewis acids capable of enantiotopic differentiation of Pro (R) or Pro (S) chloride groups on an sp3 C center. It takes place with an enantiomeric ratio of 94:6 to provide α-chloroalkylboronates, II, in 70-75% chem. yields. Chiral Lewis acids examined in this study were prepared in situ from ZnEt2, Yb(OTf)3, Cu(OTf)2, Zn(OTf)2 or Lu(OTf)3 and chiral ligands including amino alcs. and bisoxazolines. Highest enantioselectivity (88% ee) was observed with the chiral Lewis acid derived from Yb(OTf)3 and bisoxazoline III. This is the 1st example of a chiral Lewis acid catalyzed enantioselective 1,2-migration reaction of dichloromethylborate complexes.

From this literature《Enantiotopic Differentiation of pro-R or pro-S Chlorides in (Dichloromethyl)borates by Chiral Lewis Acids: Enantioselective Synthesis of (α-Chloroalkyl)boronates》,we know some information about this compound(132098-59-0)Computed Properties of C19H18N2O2, but this is not all information, there are many literatures related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 132098-59-0, is researched, Molecular C19H18N2O2, about Chiral Calcium Complexes as Bronsted Base Catalysts for Asymmetric Addition of α-Amino Acid Derivatives to α,β-Unsaturated Carbonyl Compounds, the main research direction is Michael addition product enantioselective preparation; pyrrolidine enantioselective preparation; asym addition reaction cycloaddition amino acid unsaturated carbonyl compound; chiral calcium complex asym addition reaction cycloaddition.Computed Properties of C19H18N2O2.

A novel catalyst system based on complexes of calcium which promote the catalytic asym. 1,4-addition reactions and [3+2] cycloaddition reactions of α-amino acid derivatives with α,β-unsaturated carbonyl compounds have been developed. The reactions proceeded smoothly in the presence of 5-10 mol % of the chiral calcium catalyst to afford the desired adducts in high yields with high diastereo- and enantioselectivities. A wide range of α,β-unsaturated esters and amides were applicable, and other glycine and even dl-alanine derivatives reacted with several α,β-unsaturated carbonyl compounds to afford the corresponding substituted pyrrolidine derivatives in high yields with excellent diastereo- and enantioselectivities. In the reactions with dl-alanine derivatives, quaternary asym. carbons were constructed efficiently.

From this literature《Chiral Calcium Complexes as Bronsted Base Catalysts for Asymmetric Addition of α-Amino Acid Derivatives to α,β-Unsaturated Carbonyl Compounds》,we know some information about this compound(132098-59-0)Computed Properties of C19H18N2O2, but this is not all information, there are many literatures related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lourenco, Mirtha A. O.; Carneiro, Liliana; Mayoral, Alvaro; Diaz, Isabel; Silva, Ana R.; Ferreira, Paula researched the compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane( cas:132098-59-0 ).Safety of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane.They published the article 《Chiral periodic mesoporous copper(II) bis(oxazoline) phenylene-silica: A highly efficient and reusable asymmetric heterogeneous catalyst》 about this compound( cas:132098-59-0 ) in Journal of Catalysis. Keywords: chiral periodic mesoporous copper oxazoline phenylene silica; efficient reusable asym heterogeneous catalyst. We’ll tell you more about this compound (cas:132098-59-0).

We describe the preparation of an effective and reusable heterogeneous asym. catalyst. A novel chiral periodic mesoporous phenylene-silica containing high d. of bis(oxazoline) moieties is prepared by co-condensation method with 1,4-bis(triethoxysilyl)benzene. After copper(II) coordination, the material is extremely efficient on the kinetic resolution of the 1,2-diphenylethane-1,2-diol with persistent high enantioselectivities (91 – > 99%) and yields (46-43% in maximum 50% resolution) at least for five consecutive cycles. Characterization of the material after the catalytic experiments showed that the heterogeneous catalyst was very robust keeping the integrity of the structure.

There is still a lot of research devoted to this compound(SMILES：C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1)Safety of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, and with the development of science, more effects of this compound(132098-59-0) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Bis(oxazoline)copper Complexes Covalently Bonded to Insoluble Support as Catalysts in Cyclopropanation Reactions, the main research direction is oxazoline copper complex mercaptopropyl functionalized silica catalyst; vinylbenzyl oxazoline polymer complexation copper heterogeneous catalyst; cyclopropanation supported catalyst copper polymer complex; styrene ethyl diazoacetate cyclopropanation copper complex catalyst.COA of Formula: C19H18N2O2.

Chiral bis(oxazolines) were dialkylated at the methylene bridge, opening the way to immobilization at that position, keeping the C2 symmetry of the chiral ligand. Bis(oxazolines) functionalized with two allyl or vinylbenzyl groups were then grafted onto mercaptopropyl-functionalized silica. The ligands were also immobilized as homopolymers or as styrene-divinylbenzene-vinylbenzyloxazoline copolymers and complexation. The Cu(OTf)2 complexes of the immobilized ligands were used as catalysts in enantioselective cyclopropanation of styrene with Et diazoacetate. The catalyst activity is dependent both on the type of polymer and ligand; the highest activity was attained when using homopolymers and bis(oxazoline) containing indan groups on silica and polymer supports. Bis(oxazoline) bearing tert-Bu groups showed good enantioselectivity only when supported on homopolymers. Some of the heterogeneous catalysts can be easily recovered and reused, as many as five times, with the same yield and stereoselectivity.

There is still a lot of research devoted to this compound(SMILES：C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1)COA of Formula: C19H18N2O2, and with the development of science, more effects of this compound(132098-59-0) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Organic Chemistry called Enantiopure Fluorous Bis(oxazolines): Synthesis and Applications in Catalytic Asymmetric Reactions, Author is Bayardon, Jerome; Sinou, Denis, which mentions a compound: 132098-59-0, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2, Category: indole-building-block.

Various enantiopure fluorous bis(oxazolines) with fluorine content between 52.7 and 58.7% have been synthesized by a simple reaction sequence that involved the introduction of two fluorinated ponytails by alkylation of the corresponding nonfluorous bis(oxazolines). For example, the 2,2′-[1-(heptadecafluoroundecyl)dodecylidene]bis[4,5-dihydro-4-(1-methylethyl)-4-oxazolemethanol] (I) was prepared in several steps. These new ligands have been used in palladium-catalyzed alkylation of α-[(1E)-2-phenylethenyl]benzenemethanol acetate with carbon nucleophiles and in copper-catalyzed oxidation of cycloalkenes. The stereoselective allylic alkylation of α-[(1E)-2-phenylethenyl]benzenemethanol acetate with propanedioic acid di-Me ester gave [(1R,2E)-1,3-diphenyl-2-propenyl]propanedioic acid di-Me ester in 89% enantiomeric excess. These ligands exhibited enantioselectivities up to 98 and 77%, resp., quite close to the values obtained using the analogous nonfluorous bis(oxazolines). These ligands could be easily recovered by liquid-liquid extraction or solid-liquid separation and reused with the same enantioselectivities.

There is still a lot of research devoted to this compound(SMILES：C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1)Category: indole-building-block, and with the development of science, more effects of this compound(132098-59-0) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 132098-59-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Polymer-Supported Bis(oxazoline)-Copper Complexes as Catalysts in Cyclopropanation Reactions. Author is Burguete, M. Isabel; Fraile, Jose M.; Garcia, Jose I.; Garcia-Verdugo, Eduardo; Luis, Santiago V.; Mayoral, Jose A..

Bis(oxazolines) are easily immobilized by functionalization of the central methylene bridge with polymerizable groups and subsequent polymerization Polymers are transformed into copper catalysts active in the cyclopropanation of styrene with Et diazoacetate. The results are similar or even better than those obtained with the similar homogeneous systems, and the catalysts can be easily recovered and reused. Substitution in the methylene bridge leads to a slight reduction in the enantioselectivity and an unexpected cis-preference.

From this literature《Polymer-Supported Bis(oxazoline)-Copper Complexes as Catalysts in Cyclopropanation Reactions》,we know some information about this compound(132098-59-0)Recommanded Product: 132098-59-0, but this is not all information, there are many literatures related to this compound(132098-59-0).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles