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A one-pot approach has been developed for the synthesis of 2,3-disubstituted indoles through a base-mediated N-alkylation of 2-(tosylamino)aryl-substitued para-quinone methides with halomethylaryl ketones followed by intramolecular cyclization and tosyl group elimination sequence. This one-pot protocol provides direct access to a wide range of 2,3-disubstituted indoles in moderate to good yields under mild conditions. (C) 2021 Elsevier Ltd. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles