Category: 133831-28-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133831-28-4,Methyl 3-Formylindole-6-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 2a(100 mg, 0.49 mmol) in dry DMF (2 ml) was added NaH (60%, 22 mg,0.54 mmol) at 0 C under argon and then stirred at room temperature for 1 h.The reaction solution was cooled to 0 C, benzoyl chloride (0.07 ml,0.54 mmol) was added and then stirred at room temperature overnight. The reaction solution was poured into H2O (20 ml), and the precipitate was filtered.The crude product was purified by column chromatography on silica gel using EtOAc/PE (1/8, V/V) as elute to give 6a as a white solid (107 mg, 71%),, 133831-28-4

The synthetic route of 133831-28-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hong, Wei; Li, Jingyang; Chang, Zhe; Tan, Xiaoli; Yang, Hao; Ouyang, Yifan; Yang, Yanhui; Kaur, Sargit; Paterson, Ian C; Ngeow, Yun Fong; Wang, Hao; Journal of Antibiotics; vol. 70; 7; (2017); p. 832 – 844;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

133831-28-4, Methyl 3-Formylindole-6-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium methoxide (1 g, 0.018 mol) was added in one portion to a mixture of 2-diethylphosphonyl-2H-1,4-benzoxazin-3(4H)-one (3.42 g, 0.012 mol) and 6-methoxycarbonylindol-3-carboxaldehyde (2.55 g, 0.012 mol) in methanol (60 ml). The reaction mixture was refluxed for 21 h, then cooled at room temperature and the precipitated solid was collected by filtration, washed with methanol and dried. Yield 2.78 g (87%) as a mixture of isomers., 133831-28-4

As the paragraph descriping shows that 133831-28-4 is playing an increasingly important role.

Reference£º
Patent; Abbott GmbH & Co. KG; US7049312; (2006); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles