In an article, author is Xu, Yali, once mentioned the application of 1383716-33-3, Recommanded Product: 1383716-33-3, Name is Vps34-IN-1, molecular formula is C21H24ClN7O, molecular weight is 425.9146, MDL number is N/A, category is indole-building-block. Now introduce a scientific discovery about this category.
Highly enantioselective C2 alkylation and inverse-electron-demand [3 + 2]-cycloaddition of 3-methylindoles with 2,2′-diester aziridine were accomplished. The chemodivergent synthesis provided an access to two kinds of chiral indole derivatives in good yields and stereoselectivities in the presence of the chiral N,N’-dioxide/Tm(OTf)(3) or N,N’-dioxide/Ho(OTOf)(3) complexes. An eight-coordinated mode of N,N’-dioxide/Tm(OTf)(3) complex was confirmed by X-ray crystal diffraction to interpret the roles of additives H2O and 1,4-dioxane. In addition, the control experiments indicated that the substituent of the indole nitrogen atom determined the conversion patterns in the divergent reactions.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles