With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143141-23-5,1-(Phenylsulfonyl)-7-azaindole,as a common compound, the synthetic route is as follows.
4.2.23 1-(Phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (17) In a heat dried and nitrogen purged tricol round bottom flask, 5 (1.05 g, 4.07 mmol) was solubilized in dry THF (15 mL), cooled to -35 C then lithium diisopropylamide (5.1 mL, 10.16 mmol, 2 M) was added slowly. The mixture was then cooled to -55 C and dry ice was added slowly. The mixture was left to warm up to room temperature under stirring overnight. The reaction was quenched with water and extracted with EtOAC. The aqueous layer was acidified by the addition of a 6 N hydrochloric acid solution to pH = 1 and extracted with EtOAC. The latter organic layer was washed with a saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give 1.09 g of the expected product as a beige solid in 88% yield. 1H NMR (300 MHz, DMSO-d6) delta (ppm): 13.87 (br, 1H), 8.51 (dd, J = 1.6, 4.7 Hz, 1H), 8.26 (d, J = 7.0 Hz, 2H), 8.13 (dd, J = 1.6, 7.9 Hz, 1H), 7.77 (dd, J = 7.2 Hz, 1H), 7.72-7.65 (m, 2H), 7.39 (dd, J = 4.7, 7.9 Hz, 1H), 7.28 (s, 1H). 13C NMR (75 MHz, DMSO-d6) delta (ppm): 164.4, 149.5, 147.3, 138.5, 135.1, 133.3, 132.1, 129.8 (2C), 128.3 (2C), 121.1, 120.7, 112.5.
143141-23-5, As the paragraph descriping shows that 143141-23-5 is playing an increasingly important role.
Reference£º
Article; Baltus, Christine B.; Jorda, Radek; Marot, Christophe; Berka, Karel; Bazgier, Vaclav; Kry?tof, Vladimir; Prie, Gildas; Viaud-Massuard, Marie-Claude; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 701 – 719;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles