Synthesis of new functionally substituted 9-azabicyclo[4.2.1]nona-2,4,7-trienes by cobalt(I)-Catalyzed [6蟺 + 2蟺]-cycloaddition of N-carbocholesteroxyazepine to alkynes was written by Kadikova, Gulnara N.;D’yakonov, Vladimir A.;Dzhemilev, Usein M.. And the article was included in Molecules in 2021.HPLC of Formula: 14396-90-8 This article mentions the following:
Catalytic [6蟺 + 2蟺]-cycloaddition of N-carbocholesteroxyazepine with functionally substituted terminal alkynes and 1,4-butynediol was performed for the first time under the action of the Co(acac)2(dppe)/Zn/ZnI2 three-component catalytic system. The reaction gave previously undescribed but promising 9-azabicyclo[4.2.1]nona-2,4,7-trienes I (n-Bu, (CH2)2CN, 1-naphthyl, etc.) (in 79-95% yields), covalently bound to a natural metabolite, cholesterol. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yl)isoindoline-1,3-dione (cas: 14396-90-8HPLC of Formula: 14396-90-8).
2-(But-3-yn-1-yl)isoindoline-1,3-dione (cas: 14396-90-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 14396-90-8
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles