Category: 145513-91-3

Sayago, Francisco J.; Isabel Calaza, M.; Jimenez, Ana I.; Cativiela, Carlos published the artcile< Versatile methodology for the synthesis and α-functionalization of (2R,3aS,7aS)-octahydroindole-2-carboxylic acid>, SDS of cas: 145513-91-3, the main research area is indolecarboxylic octahydro alkylated asym synthesis; indolooxazolidinone preparation stereoselective alkylation.

An improved strategy for the effective synthesis of enantiomerically pure (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, based on the formation of a trichloromethyloxazolidinone derivative, has been developed. Addnl., the completely diastereoselective α-alkylation of such oxazolidinone provides a very convenient and concise route to enantiopure α-tetrasubstituted derivatives of this stereoisomer of octahydroindole-2-carboxylic acid.

Tetrahedron published new progress about Alkylation, stereoselective. 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, SDS of cas: 145513-91-3.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jakkampudi, Satish; Parella, Ramarao; Arman, Hadi D.; Zhao, John C.-G. published the artcile< Diastereodivergent Synthesis of Hexahydro-6H-benzo[c]chromen-6-one Derivatives Catalyzed by Modularly Designed Organocatalysts>, HPLC of Formula: 145513-91-3, the main research area is oxo heptenal hydroxy nitrostyrene organocatalyst Michael acetalization oxidation; nitro oxoethyl hexahydrobenzochromenone enantioselective diastereoselective preparation; chromanone; diastereodivergent catalysis; domino reaction; enantioselectivity; organocatalysis; self-assembly.

The diastereodivergent synthesis of hexahydro-6H-benzo[c]chromen-6-one derivatives with good to high diastereoselectivities (up to 98:2 d.r.) and enantioselectivities (up to >99 % ee) was achieved by using a domino Michael/Michael/hemiacetalization reaction between trans-2-hydroxy-β-nitrostyrenes and trans-7-oxo-5-heptenals followed by oxidation With use of appropriate modularly designed organocatalysts that were self-assembled in-situ from amino acid derivatives and cinchona alkaloid derivatives two different diastereomers of the desired hexahydro-6H-benzo[c]chromen-6-ones were obtained from the same substrates.

Chemistry – A European Journal published new progress about Acetalization catalysts, stereoselective. 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, HPLC of Formula: 145513-91-3.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Roca-Lopez, David; Merino, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Herrera, Raquel P. published the artcile< Organocatalyzed Michael addition reaction by novel (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, a new fused proline>, HPLC of Formula: 145513-91-3, the main research area is acetone nitroolefin Michael addition.

The authors present their results on the organocatalytic enantioselective Michael addition reaction of acetone to different nitroolefines using (2R,3aS,7aS)-octahydroindole-2-carboxylic acid [(R,S,S)-Oic] as a new and suitable catalyst. Computational calculations support the results obtained with (R,S,S)-Oic vs. its diastereomeric form (S,S,S)-Oic. The final products are obtained in good yields and moderate enantioselectivities (up to 58% ee).

Synlett published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl-). 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, HPLC of Formula: 145513-91-3.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sayago, Francisco J.; Calaza, M. Isabel; Jimenez, Ana I.; Cativiela, Carlos published the artcile< A straightforward route to enantiopure α-substituted derivatives of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid>, Recommanded Product: (2R,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid, the main research area is indolecarboxylic acid octahydro stereoselective alkylation.

High yielding and remarkably selective alkylations of a suitably protected derivative of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid are described. The fused bicyclic structure of this proline analog greatly influences the stereochem. outcome of direct alkylation reactions taking place at the α-carbon and provides access to α-substituted analogs with retention of the configuration. The overall procedure allows the preparation of enantiopure α-substituted derivatives of this Oic isomer, suitably protected for their incorporation into peptides, in a straightforward manner.

Tetrahedron published new progress about Alkylation, stereoselective. 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, Recommanded Product: (2R,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Vincent, Michel; Marchand, Bernard; Remond, Georges; Jaguelin-Guinamant, Sylvie; Damien, Gerard; Portevin, Bernard; Baumal, Jean Yves; Volland, Jean Paul; Bouchet, Jean Paul published the artcile< Synthesis and ACE inhibitory activity of the stereoisomers of perindopril (S 9490) and perindoprilate (S 9780)>, Related Products of 145513-91-3, the main research area is ACE inhibitor stereoisomer perindopril perindoprilate preparation; angiotensin converting enzyme perindopril perindoprilate stereoisomer.

Preindopril, a powerful ACE (angiotensin converting enzyme) inhibitor contains 5 chiral carbons, and thus there is the possibility of 25 = 32 stereoisomers for the general structure I. These 32 stereoisomers were prepared by crosscoupling the 8 stereoisomers of benzyl perhydroindole-2-carboxylate with the 4 stereoisomers of 2-(1-carbethoxybutylamino)propionic acid, and hydrogenating the resulting benzyl esters. Each stereoisomer of perindopril furnished by saponification of the corresponding diacid stereoisomer (II) of perindoprilate which is the active form of perindopril. For each of the 32 stereoisomers of II, the in vitro ACE inhibitory potency was determined Four of them, including perindoprilate, had activities in the nanomolar range, and 4 more were ca. 10-fold less active. The 4 acid esters of I corresponding resp. to the 4 most active diacids II, in vitro were studied (1 mg/kg via the oral route) for their in vivo activity in dogs. The oral absorption of the active acid esters I and their activation to the active diacid II depended only on the chiralities of the 2 ring junction carbons of the perhydroindole ring.

Drug Design and Discovery published new progress about Chirality. 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, Related Products of 145513-91-3.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jakkampudi, Satish; Parella, Ramarao; Arman, Hadi D.; Zhao, John C.-G. published the artcile< Diastereodivergent Synthesis of Hexahydro-6H-benzo[c]chromen-6-one Derivatives Catalyzed by Modularly Designed Organocatalysts>, COA of Formula: C9H15NO2, the main research area is oxo heptenal hydroxy nitrostyrene organocatalyst Michael acetalization oxidation; nitro oxoethyl hexahydrobenzochromenone enantioselective diastereoselective preparation; chromanone; diastereodivergent catalysis; domino reaction; enantioselectivity; organocatalysis; self-assembly.

The diastereodivergent synthesis of hexahydro-6H-benzo[c]chromen-6-one derivatives with good to high diastereoselectivities (up to 98:2 d.r.) and enantioselectivities (up to >99 % ee) was achieved by using a domino Michael/Michael/hemiacetalization reaction between trans-2-hydroxy-β-nitrostyrenes and trans-7-oxo-5-heptenals followed by oxidation With use of appropriate modularly designed organocatalysts that were self-assembled in-situ from amino acid derivatives and cinchona alkaloid derivatives two different diastereomers of the desired hexahydro-6H-benzo[c]chromen-6-ones were obtained from the same substrates.

Chemistry – A European Journalpublished new progress about Acetalization catalysts, stereoselective. 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, COA of Formula: C9H15NO2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Roca-Lopez, David; Merino, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Herrera, Raquel P. published the artcile< Organocatalyzed Michael addition reaction by novel (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, a new fused proline>, Electric Literature of 145513-91-3, the main research area is acetone nitroolefin Michael addition.

The authors present their results on the organocatalytic enantioselective Michael addition reaction of acetone to different nitroolefines using (2R,3aS,7aS)-octahydroindole-2-carboxylic acid [(R,S,S)-Oic] as a new and suitable catalyst. Computational calculations support the results obtained with (R,S,S)-Oic vs. its diastereomeric form (S,S,S)-Oic. The final products are obtained in good yields and moderate enantioselectivities (up to 58% ee).

Synlettpublished new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl-). 145513-91-3 belongs to class indole-building-block, and the molecular formula is C9H15NO2, Electric Literature of 145513-91-3.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Formula: C9H15NO2, Which mentioned a new discovery about 145513-91-3

Efficient access to N-protected derivatives of (R,R,R)- and (S,S,S)-octahydroindole-2-carboxylic acid by HPLC resolution

The preparation of the proline analogue (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic) and its enantiomer, (2R,3aR,7aR)-Oic, is described. A racemic precursor has been synthesized in good yield and subjected to HPLC resolution on a chiral column. The high efficiency of both the synthetic and chromatographic procedures has allowed the isolation of multigram quantities of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Formula: C9H15NO2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 145513-91-3

Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles