Some tips on 1477-50-5

1477-50-5, The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-50-5,1H-Indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Under N2, to a solution of indole-2-formic acid (1.93g, 12mmol) in 120mL of dry Et2O was added19mL of MeLi solution dropwise (1.3M in Et2O, 24mmol) at 0C. The mixture was heated to reflux andkept for 2h and then cooled to room temperature. The saturated NH4Cl solution was added carefully to quench the reaction. The aqueous phase was extracted with Et2O and the combined organic phase waswashed with brine, dried with anhydrous MgSO4 and evaporated in vacuo. The crude product was purified by flash chromatography (PE : EA = 7 : 1) to give a white solid in 53% yield.

1477-50-5, The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Zhijie; Li, Ying; Cai, Yu; Yuan, Junying; Yuan, Chengye; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4903 – 4906;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Downstream synthetic route of 1477-50-5

The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-50-5,1H-Indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

(iii) 1H-Indole-2-carboxylic acid methyl ester 2 g of 1H-Indole-2-carboxylic acid was dissolved in 15 ml of methanolic hydrochloric acid (8M) and the mixture was stirred at RT for 16 h. After removal of the solvent under reduced pressure, reisidual volatiles were removed by codistillation twice with 10 ml toluene. The remaining slightly yellow solid was subjected to the subsequent reaction without further purification. Yield: 2.3 g, 1477-50-5

The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nazare, Marc; Essrich, Melanie; Will, David William; Matter, Hans; Ritter, Kurt; Wehner, Volkmar; US2003/199689; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

New learning discoveries about 1477-50-5

The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

1477-50-5, 1H-Indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: H2SO4 (98%) (0.5mL) was added to a stirred solution of raw material1 in CH3OH (10mL) at room temperature and the mixture was then stirred for 2-3 h at 80 C. TLC was used to monitor the reaction progress until it was complete. A large amount of ice water was then added to the mixture. A saturated solution of sodium carbonate was used to neutralise the mixture until white solid appeared. After filtering the mixed solution, compounds 2a-h (yield 91-99) were obtained.

The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ye, Ying; Suo, Yourui; Yang, Fang; Yang, Yongjing; Han, Lijuan; Journal of Chemical Research; vol. 39; 5; (2015); p. 296 – 299;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles