With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-50-5,1H-Indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Under N2, to a solution of indole-2-formic acid (1.93g, 12mmol) in 120mL of dry Et2O was added19mL of MeLi solution dropwise (1.3M in Et2O, 24mmol) at 0C. The mixture was heated to reflux andkept for 2h and then cooled to room temperature. The saturated NH4Cl solution was added carefully to quench the reaction. The aqueous phase was extracted with Et2O and the combined organic phase waswashed with brine, dried with anhydrous MgSO4 and evaporated in vacuo. The crude product was purified by flash chromatography (PE : EA = 7 : 1) to give a white solid in 53% yield.
1477-50-5, The synthetic route of 1477-50-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wu, Zhijie; Li, Ying; Cai, Yu; Yuan, Junying; Yuan, Chengye; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4903 – 4906;,
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