Category: 14805-29-9

Chemistry is an experimental science, name: exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14805-29-9, Name is exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES

Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII), respectively wherein, R1 and R2 are individually selected from hydrogen, alkyl, substituted or alkyl; n=0, 1, or 2; Y=NR3R4, OR5, or SR5, where R3 and R4 are individually selected from acyl or sulfonyl, and where R5 is aryl or heteroaryl, or heterocyclic; and Ar is an aryl, heteroaryl, or heterocyclic compound.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14805-29-9, in my other articles.

Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

14805-29-9, exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2To the reaction mixture containing Compound (C) which was obtained in the above Example 1 were added (3aR,4S,7R,7aS)-hexahydro-4,7-methano-2H-isoindole-1,3-dione [Compound (D)] (22.6 g, 136.8 mmol), potassium carbonate (15.1 g, 109.3 mmol) and toluene (44 g).Then, the toluene (44 g) was distilled out from the mixture, water (0.82 g) was added thereto, and the resulting mixture was reacted under reflux for 8 hours.Then, the reaction mixture was cooled to room temperature, and water (400 g) was added to the mixture.The mixture was separated with a separating funnel, and the toluene layer was washed with 2.3percent (W/W) brine (350 g).Further, active carbon (1.8 g) was added to the toluene solution, and the mixture was stirred for 1 hour.The active carbon was removed by filtration to give a toluene solution containing (3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl) piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione (2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]-methyl]hexahydro-(3aS,4R,7S,7aR)-4,7-methano-1H-isoindole-1,3(2H)-dione) [Compound (E)] (341.4 g).The yield of Compound E was 94.3percent The yield of Compound (E) was calculated based on the analytical result that the content of the compound in the toluene solution was 12.4percent (w/w) (which was calculated by LC absolute calibration curve method).And, the production rate of by-product (R) was 0.013percent (which was calculated with the following formula (a))., 14805-29-9

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Reference£º
Patent; Dainippon Sumitomo Pharma Co., Ltd.; US2011/263848; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14805-29-9,exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione,as a common compound, the synthetic route is as follows.

A mixture of bicyclo[2.2.1]heptane-2,3-di-exo-carboximide (prepared as described in Chem. Pharm. Bull., 1991 p 2288; 1.0 g, 6.05 mmol), ethyl chloroacetate (1.3 mL, 12.1 mmol), TBAB (39 mg, 0.12 mmol) and potassium carbonate (1.17 g, 8.48 mmol) were irradiated in microwawe for 10 min at 150 C. (150 W). The mixture was then diluted with water and EtOAc. Organic phase was separated, and aqueous phase was extracted with EtOAc (3¡Á15 mL). Combined organic phases were washed with brine (1¡Á15 mL), dried over Na2SO4, filtered and concentrated to afford the title compound as a brown oil (1.74 g, 114%)., 14805-29-9

As the paragraph descriping shows that 14805-29-9 is playing an increasingly important role.

Reference£º
Patent; Merck Patent GmbH; JORAND-LEBRUN, Catherine; JOHNSON, Theresa L.; GRAEDLER, Ulrich; JIANG, Xuliang; KULKARNI, Santosh; (23 pag.)US2017/283427; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14805-29-9,exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione,as a common compound, the synthetic route is as follows.

Example 2To the reaction mixture containing Compound (C) which was obtained in the above Example 1 were added tetra-n-butyl ammonium hydrogen sulfate (0.62 g, 1.83 mmol), (3aR,4S,7R,7aS)-hexahydro-4,7-methano-2H-isoindole-1,3-dione [Compound (D)] (11.3 g, 68.4 mmol), potassium carbonate (7.6 g, 55.0 mmol) and water (0.4 g), and the resulting mixture was reacted under reflux for 3 hours. Then, the reaction mixture was cooled to room temperature, and water (200 g) was added to the mixture. The mixture was separated with a separating funnel, and the toluene layer was washed with 2.3percent (W/W) brine (175 g). Further, active carbon (0.9 g) was added to the toluene solution, and the mixture was stirred for 1 hour. The active carbon was removed by filtration to give a toluene solution containing (3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-piperazin-1-ylmethyl]cyclohexylmethyl}-hexahydro-4,7-methano-2H-isoindole-1,3-dione (2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]-cyclohexyl]methyl]hexahydro-(3aS,4R,7S,7aR)-4,7-methano-1H-isoindole-1,3(2H)-dione) [Compound (E)] (266.5 g). The yield of Compound E was 94.3percent. The yield of Compound (E) was calculated based on the analytical result that the content of the compound in the toluene solution was 7.9percent (w/w) (which was calculated by LC absolute calibration curve method). And, the production rate of by-product (R) was 0.12percent (which was calculated with the above formula (a))., 14805-29-9

As the paragraph descriping shows that 14805-29-9 is playing an increasingly important role.

Reference£º
Patent; Dainippon Sumitomo Pharma Co, Ltd.; US2011/263847; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles