Electro-oxidation of diclofenac at boron doped diamond: Kinetics and mechanism was written by Zhao, Xu;Hou, Yining;Liu, Huijuan;Qiang, Zhimin;Qu, Jiuhui. And the article was included in Electrochimica Acta in 2009.COA of Formula: C14H9Cl2NO This article mentions the following:
Diclofenac is a common antiinflammatory drug. Its electrochem. degradation at B doped diamond electrode was studied in aqueous solution The degradation kinetics and the intermediate products were studied. Electrooxidation was effective in inducing the degradation of diclofenac with 30 mg/L initial concentration, ensuring a mineralization degree of 72% after a 4 h treatment with the applied bias potential of 4.0 V. The effects of applied bias potential and addition of NaCl on diclofenac degradation were studied. Different degradation mechanisms of diclofenac were involved at various applied bias potentials. With the addition of NaCl, some chlorination intermediates including dichlorodiclofenac were identified, which lead to the total organic C increase compared with the electrolysis process without NaCl addition at the reaction initial period. The main intermediates including 2,6-dichlorobenzenamine, 2,5-dihydroxybenzyl alc., and HOBz are identified at the time of 2 h. 1-(2,6-Dichlorocyclohexa-2,4-dienyl)indolin-2-one were also identified. 1-(2,6-Dichlorocyclohexa-2,4-dienyl)indolin-2-one was also identified. These intermediates disappeared gradually with the extension of reaction time. Small mol. acids were identified finally. Based on these results, a degradation pathway of diclofenac is proposed. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0COA of Formula: C14H9Cl2NO).
1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.COA of Formula: C14H9Cl2NO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles