Category: 162100-42-7

Sekhar, Abinitha S.’s team published research in International Journal of Pharmaceutical Sciences Review and Research in 2016 | CAS: 162100-42-7

6-Chloro-5-methyl-1H-indole(cas: 162100-42-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 162100-42-7

In 2016,International Journal of Pharmaceutical Sciences Review and Research included an article by Sekhar, Abinitha S.; Saranya, T. S.; Baskar, Vaishnav; Manakadan, Asha Ashokan. Application of 162100-42-7. The article was titled 《In silico approach of apoptosis induing ability of different indole derivatives by interaction with caspase9》. The information in the text is summarized as follows:

Indole compounds are well known for their wide variety of pharmacol. activities. It is the combination of benzene with pyrrole ring. Compounds having indole group are biol. important. They are used as antimicrobial, antiviral, antitubercular, antiinflammatory, anticancer, ant-diabetic and anticonvulsant agents. Because of the wide variety of biol. application, several substituted indole derivatives are studied for their mol. structure, mol. docking and bioavailability. The purpose of the study is to carry out the docking studies of indole derivatives containing electrophilic substitution and nucleophilic substitution with the anticancer target casp9. Fifty compounds were designed and by using Argus lab version 4.0.1. Their docking score was calculated and compared with the standard drug casodex. The drug likeness of compounds was performed using Lipinski rule of five. Result showed that 1,1′-(1H-indole-5,6-diyl)diethanone and 5-(trichloromethyl)-1H-indole and the phytoconstituent curcumin showed better docking score than that of the standard drug casodex. It is concluded that certain indole derivatives show greater affinity with casp9 protein. These compounds may be helpful in studying anticancer targets for casp9 protein. In the part of experimental materials, we found many familiar compounds, such as 6-Chloro-5-methyl-1H-indole(cas: 162100-42-7Application of 162100-42-7)

6-Chloro-5-methyl-1H-indole(cas: 162100-42-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 162100-42-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 162100-42-7

162100-42-7 6-Chloro-5-methyl-1H-indole 10773354, aindole-building-block compound, is more and more widely used in various fields.

162100-42-7, 6-Chloro-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,162100-42-7

To a solution of Compound D (3.5 g, 21 mmol) in AcOH (40 mL) was added sodium cyanoborohydride (2.7 g, 43 mmol) and the mixture was purged with N2 for 1 h at room temperature.The reaction was complete by TLC (PE / EA = 10/1), further ethyl acetate EA (200 ml) was added and the mixture was made basic with a 5N NaOH solution (200 ml) at a pH of about 8. The organic layer was separated, Wash once, fullAnd brine once, dried over anhydrous sodium sulfate, dried to give 3.5g of brown solid Compound E, spare. Yield 98%.

162100-42-7 6-Chloro-5-methyl-1H-indole 10773354, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; Douchuang (Shanghai) Pharmaceutical Technology Co., Ltd.; Wang Lei; Wang Xiaolei; Gao Jixiang; (9 pag.)CN106278987; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

New learning discoveries about 162100-42-7

162100-42-7, The synthetic route of 162100-42-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162100-42-7,6-Chloro-5-methyl-1H-indole,as a common compound, the synthetic route is as follows.

a) 1-(6-Chloro-5methyl-1H-indol-3-yl)-2,2,2-trifluoro-ethanone; Using a procedure described in J. Med. Chem. 1991, 34, 140, from 0.250 g (0.002 mol) of 6-chloro-5-methyl-1H-indole were prepared 0.38 g (96%) of the title compound as a white solid.

162100-42-7, The synthetic route of 162100-42-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick; US2007/21463; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles