16502-01-5 | - Indole Building Blocks

Dinesha, H. E. et al. published their research in Asian Journal of Chemistry in 2019 | CAS: 16502-01-5

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole (cas: 16502-01-5) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 16502-01-5

A novel method for synthesis of tetrahydro-2H-oxazolo[2,3-a]isoquinolines was written by Dinesha, H. E.;Sandhya, N. C.;Mantelingu, K.. And the article was included in Asian Journal of Chemistry in 2019.Application of 16502-01-5 This article mentions the following:

An efficient and direct method for the synthesis of tetrahydro-2H-oxazolo[2,3-a]isoquinolines I [R = H, 6-OMe; R¹ = H, Me, Ph; R² = H, 4-Me, 2-Br, etc.] was reported. This novel method involved T3P mediated in situ oxidation of benzyl alcs. to aldehyde followed by acetic acid mediated [3 + 2] cycloaddition reaction to afford tetrahydro-2H-oxazolo[2,3-a]isoquinolines I in one-pot operation with good to excellent yields. Heterocyclic alcs. also underwent the reaction with tetrahydroquinolines at room temperature In the experiment, the researchers used many compounds, for example, 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole (cas: 16502-01-5Application of 16502-01-5).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 16502-01-5

16502-01-5, 16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.

16502-01-5, 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(B) will be 516 mg intermediate A dissolved in CH2Cl2In, adding 443 mg of benzoyl chloride (BzCl), under the condition in the ice bath, slowly dropping 455 mg triethylamine (Et3N), stirring at room temperature the reaction 2 h, monitoring after the reaction is complete, the reaction system for CH2Cl2(20 ml) dilution, then adding pure water extraction three times, and finally a saturated salt water, extracted into the organic phase collected drying, turns on lathe does, over silica gel column chromatography separation to obtain 671 mg of intermediate B2, column chromatography in eluting agent is PE/EtOAc=2:1, the reaction yield is 81%; product is a white solid at room temperature.

16502-01-5, 16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Fuzhou University; Chen Haijun; Ye Jinxiang; Wu Jianlei; Lv Tingting; Li Cailong; Gao Yu; (13 pag.)CN106883230; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Simple exploration of 16502-01-5

16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16502-01-5,2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole,as a common compound, the synthetic route is as follows.

To a stirred solution of tryptoline (2,3,4,9-tetrahydro-1 /-/-pyrido[4,3-b]indole) (150 g, 0.871 mol) in THF (1 .5 L) at 0 C, triethylamine (243 ml_, 1 .74 mol) and di-ferf-butyl dicarbonate (228 g, 1.04 mol) were added and the reaction mixture was stirred at 25 C for 12 h. After the completion of the reaction (monitored by TLC), water was added to the reaction mixture under ice-cooling and extracted with ethyl acetate (2 x 500 ml_). The combined organic extracts were washed with brine (1 x 250 ml_), dried over anhydrous Na2S04,filtered and evaporated under reduced pressure to get the crude product. The crude material was stirred with diethyl ether (200 mL) and the solid thus obtained was filtered, washed with diethyl ether (2 x 100 mL) and dried to afford the title compound as brown solid (200 g, 84 %).1H-NMR (400 MHz, CDCI3) d = 7.94 (br-s, 1 H), 7.51 (d, J = 7.60 Hz, 1 H), 7.33-7.34 (m, 1 H), 7.1 1 -7.13 (m, 2H), 4.67 (s, 2H), 3.79 (br-s, 2H), 2.83 (br-s, 2H), 1.53 (s, 9H).MS: 273.2 (M+H)+., 16502-01-5

16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (0 pag.)WO2019/233883; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles