Oxidation of 1-acylindoles with oxodiperoxomolybdenum (VI), peroxomolybdenum.HMPA. Preparation of 2,3-dihydroxyindoline and indoxyl derivatives was written by Chien, Chun Sheng;Suzuki, Takako;Kawasaki, Tomomi;Sakamoto, Masanori. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Recommanded Product: 1-Acetylindolin-3-one This article mentions the following:
The oxidation of 1-acylindoles with MoO5.HMPA, in dry methanol gives a variety of products depending on the indole substituents; trans (I)- and cis (II)-1-acyl-3-hydroxy-2-methoxyindolines are obtained from 2,3-unsubstituted 1-acylindoles, 1-acetyl-2-hydroxy-3-methoxy-3-methylindoline (III) from 1-acetyl-3-methylindole, 1-acetyl-2,3-dihydroxy-2,3-dimethylindoline from 1-acetyl-2,3-dimethylindole, and 1-acetyl-2-hydroxy-2-methylindoxyl from 1-acetyl-2-methylindole. Reaction of I and II with acids gives 1-acylindoxyl while reaction of III with the acid gives 3-methyloxindole. Treatment of 3-acetoxy-1-acetyl-2-methoxyindoline with SnCl4 gives 1-acetylindoxyl and 1-acetyl-3-chloroindole. In the experiment, the researchers used many compounds, for example, 1-Acetylindolin-3-one (cas: 16800-68-3Recommanded Product: 1-Acetylindolin-3-one).
1-Acetylindolin-3-one (cas: 16800-68-3) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 1-Acetylindolin-3-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles