Category: 1731037

伪-Xanthylmethyl Ketones from 伪-Diazo ketones was written by Lopez-Mendoza, Pedro;Miranda, Luis D.. And the article was included in Synthesis in 2021.SDS of cas: 6639-06-1 This article mentions the following:

A simple and efficient method to obtain 伪-xanthylmethyl ketones from 伪-diazo ketones is described. The reaction proceeds through a protonation/nucleophilic substitution sequence in the presence of p-toluenesulfonic acid and potassium Et xanthogenate as the nucleophile. As 伪-diazo ketones can be readily synthesized from ubiquitous carboxylic acids, a broad variety of xanthates can be obtained, including examples from naturally occurring substrates. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1SDS of cas: 6639-06-1).

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 6639-06-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Analysis of indole acid derivatives by gas chromatography using liquid phase OV-101 was written by Grunwald, Claus;Lockard, R. G.. And the article was included in Journal of Chromatography in 1970.Quality Control of 3-(1H-Indol-1-yl)propanoic acid This article mentions the following:

One stationary phase (OV-101, a dimethylsiloxane polymer) and 2 derivatives (Me esters and trimethylsilyl derivatives) resolved 9 or 10 closely related acidic indoles at the 99% level. This is better resolution than has been obtained with other stationary phases. Bis(trimethylsilyl)-trifluoroacetamide was more effective than bis(trimethylsilyl)-acetamide as a reagent for producing trimethylsilyl derivatives The column was packed with 80-90 mesh Anakrom ABS coated with 5% OV-101. The carrier gas was He. The column temperature was 200掳; the flash heater and flame ionization detector, 250掳. The relative retention values, compared to ethyl indole-3-acetate, varied from 0.72 to 6.31 for the trimethylsilyl derivatives and from 0.18 to 4.73 for the Me ester derivatives In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Quality Control of 3-(1H-Indol-1-yl)propanoic acid).

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 3-(1H-Indol-1-yl)propanoic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reactions of unsaturated bromocarbonyl compounds with primary amines. II. The preparation of 1,2,5-substituted pyrroles was written by Schulte, K. E.;Zinnert, F.. And the article was included in Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft in 1955.Safety of 3-(1H-Indol-1-yl)propanoic acid This article mentions the following:

Condensation of AcH and PhAc (Dubois C.A. 43, 6159i) gave crotonophenone, b₈ 122掳, which brominated in HOAc gave 2,3-dibromobutyrophenone, m. 93-4掳. Reaction with N-bromosuccinimide gave the same dibromo derivative and an impure oily product, presumably 4-bromocrotonophenone, which on condensation-with BuNH₂ gave an impure product (no anal.), presumably 1-butyl-2-phenylpyrrole, absorption maximum at 2210 A. Friedel-Crafts reaction of benzene and 2-hexenoyl chloride gave 54.6% 2-hexenophenone (I); semicarbazide, m. 162.5-3.5掳. Bromination of I in HOAc and recrystallization from MeOH gave 2,3-dibromohexanophenone, m. 59.5-60.5掳. Bromination of 3.5 g. I in 20 cc. CCl₄ with 3.6 g. N-bromosuccinimide and 25 mg. Bz₂O₂ under reflux gave 4.5 g. oil, presumably 4-bromo-2-hexenophenone. A solution of 2.6 g. of this product in 40 cc. petr. ether and 5 g. BuNH₂ in 20 cc. 50% EtOH shaken 5 min., dried with Na₂SO₄ and the solution fractionally distilled gave 0.9 g. of a viscous oil analyzing correctly for 1-butyl-2-ethyl-5-phenylpyrrole, b₈ 148-9掳, absorption maximum 2210 A. Et crotonate (14.8 g.) refluxed 4 h. with 23 g. N-bromosuccinimide and 100 mg. Bz₂O₂, cooled, filtered and the solution fractionally distilled gave 60% Et 4-bromocrotonate, b₁₅ 80-81掳. Et 2-hexenoate, b₁₈ 73-4掳, and Et 2-decenoate, b₂₀ 138.5-5掳, were prepared in 81.5 and 76.1% yield, resp., from the acids via the acid chlorides. Bromination of these esters with N-bromosuccinimide gave 64%-Et 4-bromo-2-hexenoate, b₁₈ 119-21掳, and 53.5% Et 4-bromo-2-decenoate, b₁₅ 162-4掳. Neither these esters or Et 4-bromocrotonate gave pyrrole derivatives on reaction with aniline or with BuNH₂. 2-Penten-4-one, 3-hexen-2-one, 2-methyl-2-methyl-2-penten-4-one, 3-undecen-2-one, and 2-methyl-2-pentenal gave no pure bromo derivatives on reaction with N-bromosuccinimide. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Safety of 3-(1H-Indol-1-yl)propanoic acid).

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Safety of 3-(1H-Indol-1-yl)propanoic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Relation of chemical structure to plant growth-regulator activity in the pineapple plant. V. Post-harvest delay of senescence of pineapple fruit was written by Gortner, Willis A.;Leeper, Robert W.. And the article was included in Botanical Gazette (Chicago) in 1969.Formula: C11H11NO2 This article mentions the following:

The effects of 369 compounds, including 94 phenoxyacetic acids, 43 other phenoxy acids, 23 phenylacetic acids, 15 hydrocinnamic acids, 9 benzoic acids, 7 salicylic acids, 48 naphthalene derivatives, 22 indole acids, 5 hydrazine derivatives, and 8 cinnamic acids, for postharvest delay of senescence of pineapple fruit (Ananas comosus) were determined Seventy-six of the compounds were active, and 27 were highly active in delaying senescence. In the phenoxyacetic acid series, high activity was obtained from some halogen-substituted acids but not generally from Me-substituted acids. In the phenoxy-伪-propionic acid series, high activity was not observed for a number of halogen- and Me-substituted acids. None of the substituted phenoxy acids other than HOAc and 伪- propionic showed even moderate activity. An appreciable number of Cl-substituted phenylacetic acids and several benzoic acids showed activity. None of the phenylalkylcarboxylic acids other than HOAc showed even moderate activity. None of the salicylic acid, phthalic acids, or phthalamic acids showed any activity. All hydrazine derivatives were inactive. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Formula: C11H11NO2).

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Formula: C11H11NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles