17380-18-6, 5-Cyanoindole-3-carboxyaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
14) Removal of triphenylphosphine oxide from 3-[2-(3.4-dichlorophenyl)-ethenyl]indole-5-carbonitrile reaction mixture using MgCl2(2.2 eq) n-Butyllithium (2.5M solution in hexanes, 3.6 ml) was added to a stirred solution of (3,4-dichlorobenzyl)triphenylphosphonium bromide (4.4 g) in tetrahydrofuran (20 ml) at 0-5C under nitrogen and the mixture then stirred at ambient temperature for 30 minutes. 3-Formylindole-5-carbonitrile (1.0 g) was added in portions over 5 minutes. The resulting mixture was stirred for 25 minutes, diluted with tetrahydrofuran (10 ml) and then heated under reflux for 2.5 hours. water (20 ml) followed by ethyl acetate (25 ml) were added to the cooled mixture and the layers were separated. The ethyl acetate layer was washed with water (2 x 30 ml) and then brine (30 ml), then dried (MgSO4) and the solvent removed in vacuo to give a residue which was analyzed by NMR for triphenylphosphine oxide content., 17380-18-6
As the paragraph descriping shows that 17380-18-6 is playing an increasingly important role.
Reference£º
Patent; BASF AKTIENGESELLSCHAFT; EP850902; (1998); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles