Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1744-22-5, Name is 6-(Trifluoromethoxy)benzo[d]thiazol-2-amine, SMILES is NC1=NC2=CC=C(OC(F)(F)F)C=C2S1, in an article , author is Wang, Ting, once mentioned of 1744-22-5, Safety of 6-(Trifluoromethoxy)benzo[d]thiazol-2-amine.
Different site selectivities have been reported for indoles with different directing groups in copper-catalyzed site-selective C-H arylations. Computational and mass spectrometric studies have been conducted in an effort to understand the origin of site selectivity and the effects of the directing groups. A Heck-like mechanism involving a four-membered ring is found in all three of the cases studied. For N-acetyl indole with a weak directing group, a neutral Heck-like mechanism is controlled by an electronic effect resulting in C2 site selectivity. In contrast, indole with a N-P(O)Bu-t(2) group and N-benzyl-3-pivaloyl indole prefer a cationic Heck-like reaction in which a favorable six-membered chelation between the directing group and the Cu-III center determines the C6 and C5 site selectivities.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 1744-22-5, you can contact me at any time and look forward to more communication. Safety of 6-(Trifluoromethoxy)benzo[d]thiazol-2-amine.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles