19005-93-7 | - Page 7 of 11 - Indole Building Blocks

Kanta Mahato, Rajani team published research on Asian Journal of Organic Chemistry in 2021 | 19005-93-7

Electric Literature of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, first isolated in 1866, has the molecular formula C8H7N, and it is commonly synthesized from phenylhydrazine and pyruvic acid, 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. although several other procedures have been discovered.Indole is a colourless solid having a pleasant fragrance in highly dilute solutions. It melts at 52.5° C (126.5° F). Electric Literature of 19005-93-7.

Kanta Mahato, Rajani;Kumar Mudi, Prafullya;Deb, Mayukh;Biswas, Bhaskar research published 《 A Direct metal-free synthetic approach for the efficient production of privileged benzimidazoles in water medium under aerobic condition》, the research content is summarized as follows. A metal-free methodol. for the synthesis of 1,2-disubstituted and 2-substituted benzimidazoles with high to excellent yields was developed. The course of synthesis involved easy work-up, straightforward purification, inexpensive reaction setup and wide substrate scope under extremely mild and operationally simple conditions which makes the synthetic strategy more lucrative, practical and reliable. The serious challenge to carry out these reactions in a pure aqueous medium was achieved at 75°C in presence of air bubbles. The applicability of this operationally simple and metal-free synthetic approach for the gram-scale synthesis of benzimidazole derivatives with good yield (∼74%) further strengthens its potentiality for the synthesis at an industrial scale.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kassab, Asmaa E. team published research on Journal of Enzyme Inhibition and Medicinal Chemistry in 2021 | 19005-93-7

19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Recommanded Product: 1H-Indole-2-carbaldehyde

Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. Recommanded Product: 1H-Indole-2-carbaldehyde.

Kassab, Asmaa E.;Gedawy, Ehab M.;Hamed, Mohammed I. A.;Doghish, Ahmed S.;Hassan, Rasha A. research published 《 Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers》, the research content is summarized as follows. Novel tolmetin derivatives to were designed, synthesized, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumor cell lines. The cytotoxic activity of the most active tolmetin derivatives and was examined against HL-60, HCT-15, and UO-31 tumor cell lines. Compound was found to be the most potent derivative against HL-60, HCT-15, and UO-31 cell lines with IC50 values of 10.32 ± 0.55, 6.62 ± 0.35, and 7.69 ± 0.41μM, resp. Mol. modeling studies of derivative towards the VEGFR-2 active site were performed. Compound displayed high inhibitory activity against VEGFR-2 (IC50 = 0.20μM). It extremely reduced the HUVECs migration potential exhibiting deeply reduced wound healing patterns after 72 h. It induced apoptosis in HCT-15 cells (52.72-fold). This evidence was supported by an increase in the level of apoptotic caspases-3, -8, and -9 by 7.808-, 1.867-, and 7.622-fold, resp. Compound arrested the cell cycle in the G0/G1 phase. Furthermore, the ADME studies showed that compound possessed promising pharmacokinetic properties.

Kaya, Serdal team published research on Journal of Photochemistry and Photobiology, A: Chemistry in 2021 | 19005-93-7

Safety of 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Kaya, Serdal;Aydin, Hatice Gulten;Keskin, Selbi;Ekmekci, Zeynep;Menges, Nurettin research published 《 Exploring of indole derivatives for ESIPT emission: A new ESIPT-based fluorescence skeleton and TD-DFT calculations》, the research content is summarized as follows. Appropriate synthesis methods gave six different indole derivatives substituted at the C-2 or C-3 position. ESIPT emission capacities of these derivatives were investigated. It was concluded that the indole derivative containing the 1,2-dicarbonyl group at the C-2 position has ESIPT emission. Although adding water to the DMSO solution of the ESIPT-based mol. (9:1) resulted in ESIPT quenching, steady-state measurements in MeOH did not occur ESIPT quenching. TD-DFT calculation for uncovering the ESIPT mechanism emerged that the ESIPT mechanism occurred as a barrierless process. The X-ray anal. and DFT conformational anal. revealed that NH and CO groups involving proton transfer mechanisms are in the cis position. A mono-exponential decay was observed in DMSO and MeOH solutions, in which lifetimes were measured as 6.1 and 5.5 ns, resp. pH studies revealed that acidic and basic solutions of mol. 7 did not influence ESIPT emission.

Khalaj, Mehdi team published research on Applied Organometallic Chemistry in 2020 | 19005-93-7

Khalaj, Mehdi;Mousavi-Safavi, Seyed Mahmoud;Farahani, Nasrin;Lipkowski, Janusz research published 《 MgO nanopowders catalyzed synthesis of pyrano[4,3-d]thiazolo[3,2-a]pyrimidine derivatives》, the research content is summarized as follows. A cubic phase of pure MgO nanopowders was prepared in an aqueous solution containing freshly squeezed orange juice with pulp and characterized by X-ray diffraction (XRD), field emission SEM (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and Fourier transform IR (FT-IR) spectroscopic techniques. The catalytic potential of MgO nanopowders was evaluated in preparation of pyrano[4,3-d]thiazolo[3,2-a]pyrimidine and chromeno[4,3-d]thiazolo[3,2-a]pyrimidines derivatives using the three simple methods including thermal, ultrasonic irradiation, and high-speed ball milling (HSBM) technique under solvent-free conditions. All products were successfully formed in high yields.

Kondoh, Azusa team published research on Organic & Biomolecular Chemistry in 2022 | 19005-93-7

Formula: C9H7NO, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

In addition to indoleacetic acid, indigo, and tryptophan, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families. Formula: C9H7NO.

Kondoh, Azusa;Terada, Masahiro research published 《 Bronsted base-catalyzed 1,2-addition/[1,2]-phospha-Brook rearrangement sequence providing functionalized phosphonates》, the research content is summarized as follows. A new methodol. for the introduction of functional groups into an organic mol. in which a keto or a formyl group is used as the connecting site was developed by utilizing the 1,2-addition/[1,2]-phospha-Brook rearrangement sequence under Bronsted base catalysis. The reaction of aromatic aldehydes and ketones with phosphinates having functional groups such as alkynyl, bromoalkyl, N-Boc amino, and boryl groups efficiently proceeded with the aid of phosphazene base P2-tBu as the catalyst, providing densely functionalized phosphonates in good yields.

Kumar, Gautam team published research on Bioorganic Chemistry in 2020 | 19005-93-7

Kumar, Gautam;Goutami Godavari, Ambati;Tambat, Rushikesh;Kumar, Siva;Nandanwar, Hemraj;Elizabeth Sobhia, M.;Jachak, Sanjay M. research published 《 Synthesis, biological evaluation and computational studies of acrylohydrazide derivatives as potential Staphylococcus aureus NorA efflux pump inhibitors》, the research content is summarized as follows. The NorA efflux pump decreases the intracellular concentration of fluoroquinolones (ciprofloxacin, norfloxacin) by effluxing them from Staphylococcus aureus cells. The synthesis of novel acrylohydrazides I [R¹ = 2-furyl, 5-nitro-2-furyl, 4-(PhCH₂O)C₆H₄, 3,4,5-(MeO)₃C₆H₂; R² = 4-FC₆H₄, 4-pyridyl, 2-imidazolyl, 5-bromo-2-thienyl, 2-pyrrolyl, etc.] was achieved using well-known reactions, and the products were characterized by various spectroscopy techniques. The synthesized 50 compounds I were evaluated for the NorA efflux pump inhibition activity against S. aureus SA-1199B (norA++) and K1758 (norA-) strains. The study provided two most active compounds viz. I (R¹ = 2-furyl; R² = 5-bromo-2-furyl) and I [R¹ = 3,4,5-(MeO)₃C₆H₂; R² = 2-pyrrolyl]. The compound I (R¹ = 2-furyl; R² = 5-bromo-2-furyl) was found to be the most active in potentiating effect of norfloxacin and it also showed enhanced uptake, efflux inhibition in ethidium bromide assay. Furthermore, this compound also enhanced post antibiotic effect and reduced mutation prevention concentration of norfloxacin. The homol. modeling study was performed to elucidate three-dimensional structure of NorA. Docking studies of potent mols. were done to find the binding affinity and interaction with active site residues. Furthermore, all the tested compounds exhibited good ADME and drug-likeness properties in-silico.

Kumar, Sanjeev team published research on Tetrahedron Letters in 2020 | 19005-93-7

Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. Formula: C9H7NO.

Kumar, Sanjeev;Parshuram Satpute, Dinesh;Nikhil Vaidya, Gargi;Nagpure, Mithilesh;Kumar Lokhande, Shyam;Meena, Deepak;Kumar, Dinesh research published 《 Micellar catalysis enabled synthesis of indolylbenzothiazoles and their functionalization via Mn(II)-catalyzed C₂-H amination using pyridones》, the research content is summarized as follows. The sustainable synthesis of indolylbenzothiazloes was reported utilizing TPGS-750-M enabled nanomicellar catalysis in water. The reactions do not require addnl. catalysts and/or oxidants and proceed at room temperature Subsequently, the indole rings were functionalized to construct novel tris-heterocyclic scaffolds via benzothiazole directed Mn(II)-catalyzed C₂-H amination utilizing pyridones as the amine partner.

Hosseini-Sarvari, Mona team published research on Journal of Organometallic Chemistry in 2020 | 19005-93-7

Recommanded Product: 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Hosseini-Sarvari, Mona;Akrami, Zahra research published 《 Visible-light assisted of nano Ni/g-C₃N₄ with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation》, the research content is summarized as follows. A selective, economical, and ecol. protocol has been described for the oxidation of Me arenes and their analogs ArCH₂R (Ar = 3-nitrophenyl, 1-naphthyl, furan-2-yl, etc.; R = H, Me, Ph, pyridin-2-yl) and 9H-fluorene to the corresponding carbonyl compounds ArC(O)R and 9H-fluoren-9-one and epoxidation reactions of alkenes, e.g., 1,3-cyclohexadiene with mol. oxygen (O₂) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C₃N₄ exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of Me arenes, methylene arenes, and epoxidation of various alkenes under visible-light irradiation without the use of an oxidizing agent and under base free conditions.

Hua, Shixian team published research on European Journal of Medicinal Chemistry in 2020 | 19005-93-7

Application In Synthesis of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Hua, Shixian;Chen, Feihong;Gou, Shaohua research published 《 Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase》, the research content is summarized as follows. A combination therapeutic regimen via introducing tryptophan 2,3-dioxygenase inhibitors into microtubule inhibitors was performed and evaluated for their antitumor activity. Thereinto, HT2, composed of combretastatin A-4 (CA-4) and tryptophan-2,3-dioxygenase (TDO) inhibitor by a linker, displayed the most potent activity with 10-fold higher than its parent CA-4 against HepG2, A549 and HCT-116 cancer cell lines. Mechanism studies suggested that HT2 inhibited tubulin polymerization and cell migration, caused G2 phase arrest, induced apoptosis by mitochondrial mediated apoptotic pathway, concurrent depolarized the mitochondria membrane potentials and caused reactive oxygen species (ROS) production in HepG2 cells. Moreover, HT2 could enhance T-cell immune responses in vitro by releasing a TDO inhibitor to suppress TDO expression and blockade kynurenine production As expected, HT2 could remarkably promote the antitumor activity of CA-4 in either immunocompetent H22 or immunodeficient A549 tumor xenograft models without observable toxic effects. More importantly, HT2 increased the level of splenic and tumor-infiltrated T cells and in turn effectively boosted the inhibition effect in H22 xenografted tumor growth. Collectively, this immunochemotherapeutic strategy can be applied to promote chemotherapeutic effect.

Huang, Guang team published research on Journal of Medicinal Chemistry in 2020 | 19005-93-7

Huang, Guang;Murillo Solano, Claribel;Melendez, Joel;Shaw, Justin;Collins, Jennifer;Banks, Robert;Arshadi, Arash Keshavarzi;Boonhok, Rachasak;Min, Hui;Miao, Jun;Chakrabarti, Debopam;Yuan, Yu research published 《 Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines》, the research content is summarized as follows. There is an urgent need to develop new efficacious antimalarials to address the emerging drug-resistant clin. cases. Our previous phenotypic screening identified styrylquinoline UCF501 as a promising antimalarial compound To optimize UCF501, we herein report a detailed structure-activity relationship study of 2-arylvinylquinolines, leading to the discovery of potent, low nanomolar antiplasmodial compounds against a Plasmodium falciparum CQ-resistant Dd2 strain, with excellent selectivity profiles (resistance index < 1 and selectivity index > 200). Several metabolically stable 2-arylvinylquinolines are identified as fast-acting agents that kill asexual blood-stage parasites at the trophozoite phase, and the most promising compound I also demonstrates transmission blocking potential. Addnl., the monophosphate salt of I exhibits excellent in vivo antimalarial efficacy in the murine model without noticeable toxicity. Thus, the 2-arylvinylquinolines represent a promising class of antimalarial drug leads.