Category: 19012-02-3

19012-02-3, 3-Acetyl-1-methylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of N-methyl-3-acetylindol (1 mmol) and the benzaldehyde derivative (1 mmol) in methanol (10 ml) was added KOH (1 ml from a 50% solution in H2O). The mixture was heated at 60 C for 12 h then evaporated to dryness. The crude was dissolved in ethyl acetate (30 ml) then washed with HCl (1N, 10 ml) and H2O (10 ml), respectively. The organic layer was separated, dried over Na2SO4 and evaporated. The product was purified by chromatography column eluted with hexane:ethyl acetate (8:2) to yield the title compound as a yellow powder.

19012-02-3, As the paragraph descriping shows that 19012-02-3 is playing an increasingly important role.

Reference£º
Article; Martel-Frachet, Veronique; Kadri, Malika; Boumendjel, Ahcne; Ronot, Xavier; Bioorganic and Medicinal Chemistry; vol. 19; 20; (2011); p. 6143 – 6148;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

19012-02-3, 3-Acetyl-1-methylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 17 N-hydroxy-N-(1-(1-methylindol-3-yl)ethyl) urea The desired compound was prepared using the method of example 2, except using 1-methyl-3-acetyl indole, prepared as described in example 16, step a instead of acetyl benzo[b]thiophene. (R1 =NH2, A=CHCH3, X=NCH3 [3-isomer], Y=H). Melting Point: 149-150 C. NMR (300 MHz, DMSO-d6): 1.46 (d, 3H, J=7.5 Hz); 3.74 (s, 3H); 5.66 (q, 1H); 6.18 (br s, 2H); 6.94-7.15 (m, 2H); 7.24 (s, 1H); 7.36 (m, 1H); 7.64 (m, 1H); 8.88 (s, 1H). Mass Spectrum (CI-NH3): 234 (M+H)+, 251 (M+NH4)+, 158., 19012-02-3

The synthetic route of 19012-02-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbott Laboratories; US4873259; (1989); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19012-02-3,3-Acetyl-1-methylindole,as a common compound, the synthetic route is as follows.

General procedure: The substituted 1-(1H-indol-3-yl)ethanone (1 mmol), together with the respective benzaldehyde (1 mmol), malononitrile (1 mmol) and ammonium acetate (8 mmol) were dissolved in toluene (30 mL) and heated to reflux for 8 h. The solvent was removed under reduced pressure and absolute ethanol was added to the residue. The precipitate was collected by filtration and purified by silica gel column chromatography to give the desired product.

19012-02-3, 19012-02-3 3-Acetyl-1-methylindole 594156, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3149 – 3157;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19012-02-3,3-Acetyl-1-methylindole,as a common compound, the synthetic route is as follows.,19012-02-3

General procedure: To a solution of N-methyl-3-acetylindol (1 mmol) and the benzaldehyde derivative (1 mmol) in methanol (10 ml) was added KOH (1 ml from a 50% solution in H2O). The mixture was heated at 60 C for 12 h then evaporated to dryness. The crude was dissolved in ethyl acetate (30 ml) then washed with HCl (1N, 10 ml) and H2O (10 ml), respectively. The organic layer was separated, dried over Na2SO4 and evaporated. The product was purified by chromatography column eluted with hexane:ethyl acetate (8:2) to yield the title compound as a yellow powder.

19012-02-3 3-Acetyl-1-methylindole 594156, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Martel-Frachet, Veronique; Kadri, Malika; Boumendjel, Ahcne; Ronot, Xavier; Bioorganic and Medicinal Chemistry; vol. 19; 20; (2011); p. 6143 – 6148;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles