Category: 1918-77-0

In an article, author is Kato, Hikaru, once mentioned the application of 1918-77-0, Name is 2-(Thiophen-2-yl)acetic acid, molecular formula is C6H6O2S, molecular weight is 142.18, MDL number is MFCD00005458, category is indole-building-block. Now introduce a scientific discovery about this category, Quality Control of 2-(Thiophen-2-yl)acetic acid.

A family of prenylated indole alkaloids, including notoamides and stephacidins, are secondary metabolites produced by various fungi, particularly Aspergillus and Penicillium spp. These alkaloids contain a diketopiperazine or a bicycle [2.2.2] diazaoctane ring, which is derived from tryptophan, proline, and one isoprene unit. Biosynthetically, this bicyclic core is believed to be the product of an intermolecular Diels-Alder reaction. We isolated various prenylated indole alkaloids, including some putative biosynthetic precursors, from Aspergillus protuberus, Aspergillus amoenus, and, Aspergillus taichungensis, and proposed possible biosynthetic pathways of the family.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthetic Route of 1918-77-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1918-77-0, Name is 2-(Thiophen-2-yl)acetic acid, SMILES is O=C(O)CC1=CC=CS1, belongs to indole-building-block compound. In a article, author is Cai, Ju, introduce new discover of the category.

Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused indole and Spirooxindole Derivatives

An unprecedented gold-catalyzed bicyclization reaction of diaryl alkynes has been developed for the synthesis of indoles in good to high yields. Mechanistically, this alkyne bifunctionalization transformation was terminated by a stepwise formal X-H insertion reaction to furnish the corresponding polycyclic-frameworks with structural diversity, and the key intermediate 3H-indole was isolated and characterized for the first time. In addition, further transformation of these generated tetracyclic-indoles with PCC as the oxidant provided straightforward access to the spirooxindoles in high yields.

Synthetic Route of 1918-77-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1918-77-0.

Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles