194490-14-7, 5-Chloro-1H-indole-3-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
194490-14-7, To a solution of the suitable 3-cyanoindole 9 (7.03 mmol) inanhydrous DMF (10 mL) 3.61 mmol of K2CO3 and dimethyl carbonate(1.8 mL, 21.4 mmol) were added and the mixturewas heatedat 130 C for 3.5 h. After cooling (0e5 C),water and ice (25 mL)was slowly added under stirring. The oily suspension obtained wasextracted with diethyl ether (3 10 mL), the organic phase waswashed with water and brine, dried over Na2SO4 and the solventevaporated at reduced pressure to obtain the 3-cyano-1-methylindoles 10 in excellent yields. Analytical and spectroscopicdata are in accordance to those reported in literature [16].
The synthetic route of 194490-14-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Bergonzini, Cecilia; Carbone, Daniela; Cascioferro, Stella; Cirrincione, Girolamo; Dekker, Henk; Diana, Patrizia; Funel, Niccola; Geerke, Daan; Giovannetti, Elisa; Mantini, Giulia; Parrino, Barbara; Peters, Godefridus J.; Petri, Giovanna Li; European Journal of Medicinal Chemistry; vol. 189; (2020);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles