Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 198474-05-4, molcular formula is C12H9FN2O2, introducing its new discovery. Computed Properties of C12H9FN2O2
An IDO or TDO small molecule inhibitor group is directly or indirectly introduced at the position of the CA-4 hydroxyl group by use of an active group hydroxyl group in the CA-4 compound structure to obtain the compound of CA IDO/TDO-4 and AA. The invention further discloses a preparation method of the coupler. Experiments verify that the conjugate disclosed by the invention is efficient and low in toxicity and has a remarkable inhibiting effect on some human tumor cells, and the tumor cells include lung cancer, colon cancer, liver cancer, cervical cancer cells and the like. In conclusion, the conjugate of the application shows high-efficiency and low-toxicity anti-tumor immune activity through in-vitro immune related mechanisms and in-vivo tests, can be applied to preparation of drugs, and has a potential prospect in the development of antitumor drugs. (by machine translation)
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Computed Properties of C12H9FN2O2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 198474-05-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles