With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.199526-97-1,4,6-Difluoroindole,as a common compound, the synthetic route is as follows.
d. EXAMPLE 4: 2-((1-(3-BROMOBENZYL)-4,6-DIFLUORO-1H-INDOL-3- YL)SULFONYL)-N-(PYRIDIN-2-YL)ACETAMIDE; [00443] Example 4 was prepared according to the following scheme.[00444] Step A. To a solution of 4,6-diflouro-indole (15.6 g, 0.102 mol) and methyl thioglycolate (9.1 mL, 0.102 mol) in methanol: water (240mL : 60 mL) was added iodine (26.0 g, 0.102 mmol) and potassium iodide (17.0 g, 0.102 mmol). The reaction mixture was stirred at ambient temperature for 60 hours. Methanol was removed in vacuo and the aqueous layer diluted with a saturated solution of sodium bicarbonate and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, evaporated in vacuo and the resulting residue was purified on a silica gel column (0-100% ethyl acetate:hexanes over 48 min) to afford the desired product (20. lg, 76% yield). 1H NMR (400 MHz, DMSOD6) 11.74 (s, 1H), 7.51 (d, J = 2.4 Hz, 1H), 7.09 (dd, J = 2.0, 9.6 Hz, 1H), 6.90-6.85 (m, 1H), 3.54 (s, 3H), 3.51 (s, 2H).
199526-97-1, As the paragraph descriping shows that 199526-97-1 is playing an increasingly important role.
Reference£º
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; WOOD, Michael, R.; TARR, James, C.; BRIDGES, Thomas, M.; WO2011/163280; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles