Category: 21296-93-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21296-93-5,5-Chloro-2,3-dimethyl-1H-indole,as a common compound, the synthetic route is as follows.

General procedure: Thus, the general reaction conditions for pyrroleporphyrin are obtained: at -20C,B-noise 2 (0.15 mmol, 1.5 eq) was added to 1 (0.11 mmol, 1 0 0 equiv),CP3 (1 · 8mg, 2 · 5mol%)In a solution of DCM (1 .0 mL), the reaction was stirred at -20 C until TLC showed 1 to disappear. The reaction mixture was directly purified by column chromatography on silica gel eluting with PE/EA (10/1 to 4/1) to give pure product 5 as a white solid., 21296-93-5

As the paragraph descriping shows that 21296-93-5 is playing an increasingly important role.

Reference：
Patent; South University of Science and Technology of China; Tan Bin; Qi Liangwen; (16 pag.)CN107417690; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

21296-93-5, 5-Chloro-2,3-dimethyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,21296-93-5

General procedure: In a flame dried flask the imidate (1.0 equiv) was dissolved in anhydrous 1,2-dichloroethane(0.15 M) followed by the addition of the indole (1.5 equiv). To this solution freshly distilledTMSOTf (0.2 equiv) was added and the resulting mixture was stirred at rt for 3 h. The reactionmixture was then quenched with the addition of 1M NaOH. The organic layer was separated andthe aqueous layer was extracted with DCM (2x). The combined organic extracts were dried oversodium sulfate, filtered and concentrated. The residue was then purified by silica gelchromatography using the solvent systems listed for each compound.

21296-93-5 5-Chloro-2,3-dimethyl-1H-indole 2772413, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Article; Adhikari, Arijit A.; Radal, Lea; Chisholm, John D.; Synlett; vol. 28; 17; (2017); p. 2335 – 2339;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

21296-93-5, 5-Chloro-2,3-dimethyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Organic urea catalyst (2S) -2-[[[[[3,5-bis (trifluoromethyl) phenyl] amino] oxomethyl] amino] -N- (diphenylmethyl) -N, 3,3-trimethylbutyramide (44.8 mg, 0.08 mmol), 2,3-dimethyl-5-chloroindole (71.8 mg, 0.4 mmol), diphenyl phosphate (9.8 mg, 0.04 mmol) and A molecular sieve (199.5 mg) was dissolved in n-hexane (16 mL), and then ethyl trifluoropyruvate (106 muL, 0.8 mmol) was added. The reaction was carried out at room temperature for 42.5 hours. The reaction equation is as follows:The reaction solution was filtered through silica gel, rinsed with ether, and concentrated. Silica gel column chromatography was used to obtain 112 mg of a solid product. The calculated yield was 80%. The measured er value was 93: 7, and n-hexane / dichloromethane (1: 1) was used. ) Recrystallization, mother liquor was concentrated to obtain 100 mg of liquid product, the calculated yield was 72%, and the er value was 96: 4., 21296-93-5

The synthetic route of 21296-93-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Hong Kong University Of Science And Technology Shenzhen Institute; Sun Jianwei; Ma Dengke; (35 pag.)CN110437126; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles