With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.213682-04-3,4-Methoxy-1H-indole-2-carbaldehyde,as a common compound, the synthetic route is as follows.
Example 84 COMPOUND IN-076 3-(4-Methoxy-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (194 mg, 0.86 mmol), 4-methoxy-1H-indole-2-carbaldehyde (150 mg, 0.86 mmol) and piperidine (36 mg, 0.43 mmol) in ethanol (0.2M) was stirred at room temperature for a total of 5 days. The reaction was concentrated to 1/4 of its volume and the precipitate was collected by vacuum filtration to give the title compound as a pale orangish-red solid. 1H-NMR (360 MHz, DMSO-d6) delta 12.82 (s, 1H, NH), 11.36 (br s, 1h, NH), 8.11(s, 1H-H-vinyl), 8.11 (d, J=1.3 Hz, 1H), 7.63 (dd, J=1.3 & 8.5 Hz, 1H), 7.15-7.27 (m, 4H), 7.08 (d, J=7.96 Hz, 1H), 6.56 (d, J=7.7 Hz, 1H), 3.92 (s, 3H, OCH3), 2.43 (d, J=5.02 Hz, 3H, NCH3). MS m/z 384 [M++1].
213682-04-3, 213682-04-3 4-Methoxy-1H-indole-2-carbaldehyde 10678838, aindole-building-block compound, is more and more widely used in various fields.
Reference:
Patent; Tang, Peng Cho; Harris, G. Davis; Li, Xiaoyuan; US2002/52369; (2002); A1;,
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