Brief introduction of 213682-04-3

213682-04-3, 213682-04-3 4-Methoxy-1H-indole-2-carbaldehyde 10678838, aindole-building-block compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.213682-04-3,4-Methoxy-1H-indole-2-carbaldehyde,as a common compound, the synthetic route is as follows.

Example 84 COMPOUND IN-076 3-(4-Methoxy-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (194 mg, 0.86 mmol), 4-methoxy-1H-indole-2-carbaldehyde (150 mg, 0.86 mmol) and piperidine (36 mg, 0.43 mmol) in ethanol (0.2M) was stirred at room temperature for a total of 5 days. The reaction was concentrated to 1/4 of its volume and the precipitate was collected by vacuum filtration to give the title compound as a pale orangish-red solid. 1H-NMR (360 MHz, DMSO-d6) delta 12.82 (s, 1H, NH), 11.36 (br s, 1h, NH), 8.11(s, 1H-H-vinyl), 8.11 (d, J=1.3 Hz, 1H), 7.63 (dd, J=1.3 & 8.5 Hz, 1H), 7.15-7.27 (m, 4H), 7.08 (d, J=7.96 Hz, 1H), 6.56 (d, J=7.7 Hz, 1H), 3.92 (s, 3H, OCH3), 2.43 (d, J=5.02 Hz, 3H, NCH3). MS m/z 384 [M++1].

213682-04-3, 213682-04-3 4-Methoxy-1H-indole-2-carbaldehyde 10678838, aindole-building-block compound, is more and more widely used in various fields.

Reference:
Patent; Tang, Peng Cho; Harris, G. Davis; Li, Xiaoyuan; US2002/52369; (2002); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles