Category: 2338-71-8

2338-71-8, 5-Fluoro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 6-methyl-N1-(4-(pyrdin-3-yl)pyrimidin-2-yl) benzene-1,3-diamine (compound 6) (0.5 mmol) and 5-substituted, indoline-2,3-dione(isatins) or indole and aromatic aldehydes(0.5 mmol) were taken in methanol (5 ml) and stirred at60 C temperature for 4-8 h. The reaction was monitored by TLC using methanol and chloroform (2%) as a solventsystem. After completion of reaction this mixture wasevaporated by vacuum distillation and the residue wasextracted with ethyl acetate (25 mL ¡Á 3). The organic solutionwas dried over anhydrous Na2SO4 and evaporated thesolvent to offered crude product. This was further purifiedby column chromatography using 0.1:10 methanol/chloroformas eluent to obtain the pure compound in good yield., 2338-71-8

Big data shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Article; Rahim, Abdul; Syed, Riyaz; Poornachandra; Malik, M. Shaheer; Reddy, Ch. Venkata Ramana; Alvala, Mallika; Boppana, Kiran; Sridhar; Amanchy, Ramars; Kamal, Ahmed; Medicinal Chemistry Research; vol. 28; 5; (2019); p. 633 – 645;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

2338-71-8, 5-Fluoro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (336 mg, 1.5 mmol)With 5-fluoro-1H-indole-3-carboxaldehyde (81.6mg, 0.5mmol) in ethanol (5mL) solution,Add piperidine (0.3mL) and stir at 95 C for 48h.The organic phase was spin-dried, and the remaining crude product was recrystallized from ethanol to obtain the target compound.(E) -3- (5-fluoro-1H-indol-3-yl) -2-methyl-1- (3,4,5-trimethoxyphenyl) prop-2-en-1-one94.1mg, yield 51%, 2338-71-8

As the paragraph descriping shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

Add III-6 (0.50g, 3.07mmol), DMAP (75mg, 0.61mmol), DIEA (1.52mL, 9.21mmol) to 100mL three-necked flask, stir and dissolve with 10mL acetonitrile, slowly add at 05C Benzene 4-trifluoromethylbenzenesulfonyl chloride (IV-7, 0.90 g, 3.68 mmol) in 10 mL of acetonitrile solution, after completion of the addition, stirring was continued for 2 h under low temperature conditions.TLC monitoring of raw material reactionsCompletely, concentrate the reaction solution, dissolve it with 20 mL of ethyl acetate, wash with 25 mL of water, and extract twice with ethyl acetate (15 mL¡Á2)The organic phase is washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate; suction filtered, and the filtrate is dried and then subjected to column chromatography ( petroleum ether:Ethyl acetate = 10:1 rinse),After drying, 0.91 g of khaki solid V-15 was obtained.The yield was 80.25%., 2338-71-8

As the paragraph descriping shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Xu Yungen; He Guangchao; Huang Qungang; Liang Tingting; Zhang Shan; Zhu Qihua; (35 pag.)CN109942545; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of an appropriate indole, azaindole or alternative heterocycles (1.0 eq) and di-ferf-butyl dicarbonate (1eq. to 2 eq., more in particular 1.2 eq) in acetonitrile was added DMAP (0.1 to 0.5 eq. more in particular 0.1 eq). The reaction mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in dichloromethane and washed with a saturated sodium bicarbonate solution. The phases were separated. The aqueous phase was extracted with dichloromethane. The organic phases were combined, washed with a saturated ammonium chloride solution, water and brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The BOC-protected compound was used in the next step without further purification., 2338-71-8

Big data shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A solution of the xanthate 3 (1.37 g, 4.87 mmol) and the corresponding indole (4a-4g) (0.353 g, 2.21 mmol) in degassed 1,2-dichloroethane (DCE) (9 mL) was heated at reflux, and dilauroyl peroxide (DLP) (2.21 g, 5.54 mmol) in solid form was added in several portions (0.92 mmol/h). The reaction was monitored by TLC and was stopped after 6 h. The solvent was removed under reduced pressure, and the crude residues were extracted with acetonitrile and washed with hexane. The polar phase was then concentrated under reduced pressure and purified by chromatography on a silica gel column using hexane-ethyl acetate as the eluent to obtain the desired products., 2338-71-8

Big data shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Article; Canche Chay, Cristina I.; Cansino, Rocio Gomez; Espitia Pinzon, Clara I.; Torres-Ochoa, Ruben O.; Martinez, Roberto; Marine Drugs; vol. 12; 4; (2014); p. 1757 – 1772;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles