Category: 241479-67-4

In an article, author is Zhang, Xiong, once mentioned the application of 241479-67-4, Name: Isavuconazole, Name is Isavuconazole, molecular formula is C22H17F2N5OS, molecular weight is 437.4651, MDL number is N/A, category is indole-building-block. Now introduce a scientific discovery about this category.

We evaluated the influence of solvent on the alumina-promoted C3-alkylation of indoles with alpha,beta-unsaturated ketones. We found that lipophilic solvents were generally superior to hydrophilic ones with hexanes offering the 3-alkyl indole products in high yields. Thus, we demonstrate an inexpensive and procedurally simple new process that pairs acidic alumina with hexanes to achieve this important Michael alkylation. The substrate scope includes twenty-four examples with reaction yields ranging from 61 to 96%.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 241479-67-4, Name is Isavuconazole, molecular formula is , belongs to indole-building-block compound. In a document, author is Sun, Ting-Ting, HPLC of Formula: C22H17F2N5OS.

Enantioselective Halocyclization of Indole Derivatives: Using 1,3-Dihalohydantoins with Anionic Chiral Co(III) Complexes

Highly enantioselective halocyclization reactions of indole derivatives, including tryptophols and tryptamines, have been accomplished by means of anionic chiral Co(III) complexes and 1,3-dihalohydantoins (as little as 0.50 equiv). 3-Halo-fused indolines were obtained in excellent yields (up to 98%) and enantioselectivities (up to 98% ee), employing the chiral anion phase-transfer-catalysis strategy.

If you are hungry for even more, make sure to check my other article about 241479-67-4, HPLC of Formula: C22H17F2N5OS.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

241479-67-4, Name is Isavuconazole, molecular formula is C22H17F2N5OS, Application In Synthesis of Isavuconazole, belongs to indole-building-block compound, is a common compound. In a patnet, author is Qi, Xinxin, once mentioned the new application about 241479-67-4.

Palladium-catalyzed carbonylative bis(indolyl)methanes synthesis with TFBen as the CO source

An efficient and convenient palladium-catalyzed carbonylative procedure for the synthesis of bis(indolyl) methanes has been established for the first time. With TFBen (benzene-1,3,5-triy1 triformate) as the solid CO source, aryl iodides and indoles were transformed into the corresponding bis(indolyl)methane derivatives in moderate to excellent yields. (C) 2018 Elsevier Inc. All rights reserved.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles