Category: 244-76-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.244-76-8,9H-Pyrido[2,3-b]indole,as a common compound, the synthetic route is as follows.

In a 500mL 2-neck flaskIodobenzene (5.27 g, 26.0 mmol),Alpha-carboline (3.95 g, 23.0 mmol),CuI (0.13 g, 0.705 mmol),K3PO4 (9.96 g, 47.0 mmol),Trans-1,2-diaminocyclohexane (0.08 g, 0.705 mmol)And 1,4-dioxane (250 mL).after,And refluxed for 24 hours.After completion of the reaction,The solvent was distilled off under reduced pressureShort column was performed using CH2Cl2.The reaction mixture was subjected to column chromatography using CH2Cl2: hexane and then recrystallized to obtain 4.00 g of a white solid compound. (Yield: 70.0%)., 244-76-8

244-76-8 9H-Pyrido[2,3-b]indole 67486, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; LG Display Co., Ltd.; Bae, Sook Young; Lee, Sung Jae; Yang, Jung Hwan; Choe, Hyung Jong; Kim, Chun Ki; (29 pag.)KR2016/82872; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

244-76-8, 9H-Pyrido[2,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-necked 250ml flask, the compound (4) (0.6g, 1.23mmol), alpha-carboline (0.45g, 2.71mmol), NaOtBu (0.35g, 3.69mmol) were placed in toluene (100ml) was stirred under nitrogen, and the reaction temperature the temperature was raised to 80 C and reacted for 1 hour. To the resulting solution was added Pd (dba) 2 (0.02g, 0.04mmol), (tert-Bu) 3P (0.01g, 0.06mmol) and allowed to react at 80 C for 1 ~ 2days. Remove salts by filtration of the reaction solution It was. Remove the toluene was evaporated from the solution by filtration, remove the concentrate to the column to obtain the compound (3-10, AnT-DaC3) 0.49g (yield: 60%)

244-76-8, The synthetic route of 244-76-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WS Co., Ltd; Ko, Byung Soo; Kim, Kyu Sik; Oh, Yu Jin; (52 pag.)KR101528768; (2015); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

244-76-8, 9H-Pyrido[2,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A round bottom flask was charged with 9H-pyrido [2,3-b] indole (3.5 g, 21 mmol)1-bromo-4-iodobenzene (8.83 g, 31 mmol), copper (I) iodide (0.8 g, 4.2 mmol),(¡À) -trans-1,2-diaminocyclohexane (0.48 g, 4.2 mmol),Potassium phosphate tribasic (8.9 g, 42 mmol) was added and dissolved in 160 ml of toluene.Was refluxed and stirred for 24 hours. Thin layer chromatography (TLC) andAfter confirming by HPLC, the reaction was terminated. After filtration, the column (MC: Hex = 1: 4)To obtain a solid compound (5.19 g, yield = 75%)., 244-76-8

The synthetic route of 244-76-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Display Co., Ltd.; Choi Hye-ok; Lee Seung-jae; Pin Jong-gwan; Seo Bo-min; (39 pag.)KR2018/44695; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles