Category: 245-08-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.245-08-9,5H-Pyrido[3,2-b]indole,as a common compound, the synthetic route is as follows.,245-08-9

The compound a or b (5 g, 0.03 mol), 1, 3-dibromo benzene (2.8 g, 0.012 mol), copper iodide(1.04 g, 5.46 mmol), trans-1,2-diaminocyclohexane (1.33 g,10.92 mmol), and potassium phosphate tribasic (7.64 g, 0.036 mol) were dissolved in 1,4-dioxane (100 ml) and under N2 atmosphere. The mixture was allowed to stir at 110C for 48 h. After being cooled to room temperature, the mixture was diluted with THF. The copper catalyst and inorganic were removed by filtration under reduced pressure and the residue washed with dichloromethan(CH2Cl2), The organic layer was extracted with water and then CH2Cl2 was evaporated. The residue was recrystallized by CH2Cl2. The compound 1-4 were obtained as powder. 1,3-Bis(5H-pyrido[3,2-b]indol-5-yl)benzene (mCdP) (1) Yield:47% 1H NMR (500 MHz, CDCl3, ppm) delta 7.36 (2H, dd, J = 4.5 Hz, J = 8.5 Hz), 7.42 (2H, m), 7.58(4H, m), 7.72 (2H, dd, J = 2.0 Hz, J = 8.0 Hz), 7.80 (3H, m), 7.90 (1H, t, J = 8.0 Hz), 8.46(2H, d, J = 7.5 Hz), 8.64 (2H, dd, J = 1.5 Hz, J = 4.5 Hz). 13C NMR (125 MHz, CDCl3, ppm)delta 109.8, 116.6, 120.4, 121.1, 121.4, 122.8, 124.6, 125.8, 128.3, 131.6, 134.0, 138.7, 141.2, 142.5,143.0. EI-Mass (m/z): 410 [M+]

As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.

Reference£º
Article; Wang, Hedan; Zhu, Jun; Shen, Bowen; Wei, Bin; Wang, Zixing; Molecular Crystals and Liquid Crystals; vol. 651; 1; (2017); p. 133 – 141;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

245-08-9, 5H-Pyrido[3,2-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a two-necked 250 ml flask7 g (42 mmol) of delta-carboline,1-bromo-3-nitrobenzene (1-bromo-3-nitrobenzene)9.3 g (46 mmol) of CuI, 0.52 g (3 mmol) ,0.94 g (5 mmol) of 1,10-phenanthroline,22 g (104 mmol) of K3PO4 and 120 ml of dioxane were added, and the mixture was refluxed at 80 to 100 DEG C for 24 hours in a nitrogen atmosphere.After the reaction was completed, the reaction product was dissolved in methylene chloride (MC) and filtered using Celite. The filtered solution was distilled under reduced pressure and extracted with MC and distilled water.The extracted MC layer was dehydrated with MgSO4, and then purified by vacuum distillationThe solvent was removed to give a yellow solid. The solid was separated from the white solid (1) (7.5 g, yield: 65%) by column chromatography., 245-08-9

As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.

Reference£º
Patent; Raepto Co., Ltd.; Oh Yu-jin; Han Gap-jong; (27 pag.)KR2019/28878; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

245-08-9, 5H-Pyrido[3,2-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

o a 250 ml two-necked flask was added delta -carboline (15 g, 89 mmol), 1-bromo-4-iodobenzene,, CuI (1.1 g, 5.79 mmol), 1,10-phenanthroline (2 g, 11.13 mmol), K3PO4 (47 g, 220 mmol)(Dioxane, 300 ml) were put together and refluxed at 80 to 100 C under nitrogen for 24 hours. After the reaction was completed, methylene chloride(MC) and Celite filter. The filtered solution was distilled under reduced pressure, then extracted with MC and distilled waterAll. The extracted MC layer was extracted with MgSO4 and the solvent was removed by distillation under reduced pressure to obtain a yellow solid. This solidThe white solid (2) was isolated (18.7 g, 65%) using the Column Chromatography method., 245-08-9

As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.

Reference£º
Patent; WS Co., Ltd; Koh, Byung Soo; Kim, Kyu Sik; Kwak, Tae Young; Oh, Yu Jin; (36 pag.)KR2015/9205; (2015); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.245-08-9,5H-Pyrido[3,2-b]indole,as a common compound, the synthetic route is as follows.

Sub 1-3(4) round bottom flask (3.36g, 20mmol), Sub 1-2 (1) (4g, 20mmol), Pd2(dba) 3 (0.9g, 1mmol), PPh3 (0.5g, 2mmol) , the reaction proceeds at 100 C afterloading the NaOt-Bu (5.8g, 60mmol), toluene (210 mL). After completion of reaction,the organic layer was dried over MgSO4, and extracted with water and ether andrecrystallized silicagel column and the resulting organics concentrated to give 4.9g andthen the Sub 1 (B) -1. (Yield: 74%)

245-08-9, 245-08-9 5H-Pyrido[3,2-b]indole 6451402, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; DUK SAN NEOLUX CO., LTD.; PARK, JEONG KEUN; KIM, SEUL GI; PARK, HYOUNG KEUN; CHO, HYE MIN; PARK, JONG GWANG; KIM, SEOK HYEON; MOON, SOUNG YOON; LEE, TAE WON; (60 pag.)KR2015/121394; (2015); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

245-08-9, 5H-Pyrido[3,2-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

One 100 mLThe flask Intermediate (4) (0.5 g, 1.005 mmol), delta-carboline(d-carboline)0.2 g (1.105mmol), CuI 24 mg (0.126 mmol), 1,10 phenanthroline (1,10 phenanthroline) 45mg (0.251 mmol), cesium carbonate (cesium carbonate, Cs2CO3) 0.7 g (2.010 mmol) and dimethylformamide (dimethylformamide, DMF) (40 mL) and mixed, and then,stirred for 12 hours at 120 ~ 130C. The reaction was cooled to room temperature and then terminated and purified by silica gel column chromatography to give compound (4-33) 0.2 g (Yield: 40%) of a white solid was obtained., 245-08-9

As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.

Reference£º
Patent; WS Co.,Ltd; Ko, Byung Soo; Oh, Yu Jin; (61 pag.)KR2016/50891; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles