Category: 24621-73-6

Chemistry is an experimental science, SDS of cas: 24621-73-6, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 24621-73-6, Name is 4-Chloro-1H-indole-2-carboxylic acid

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 24621-73-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 24621-73-6, in my other articles.

Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， name: 4-Chloro-1H-indole-2-carboxylic acid, Which mentioned a new discovery about 24621-73-6

The beta-catenin/T-cell factor (Tcf) protein-protein interaction (PPI) plays a critical role in the beta-catenin signaling pathway which is hyperactivated in many cancers and fibroses. Based on compound 1, which was designed to target the Tcf4 G13ANDE17 binding site of beta-catenin, extensive structure-activity relationship studies have been conducted. As a result, compounds 53 and 57 were found to disrupt the beta-catenin/Tcf PPI with the Ki values of 0.64 and 0.44 muM, respectively, and exhibit good selectivity for beta-catenin/Tcf over beta-catenin/E-cadherin and beta-catenin/adenomatous polyposis coli (APC) PPIs. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) cell viability assays revealed that 56, the ethyl ester of 53, was more potent than 53 in inhibiting viability of most of the Wnt/beta-catenin hyperactive cancer cells. Further cell-based studies indicated that 56 disrupted the beta-catenin/Tcf PPI without affecting the beta-catenin/E-cadherin and beta-catenin/APC PPIs, suppressed transactivation of Wnt/beta-catenin signaling in dose-dependent manners, and inhibited migration and invasiveness of Wnt/beta-catenin-dependent cancer cells.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 24621-73-6, help many people in the next few years.HPLC of Formula: C9H6ClNO2

Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24621-73-6,4-Chloro-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.,24621-73-6

Step 1. 4-Chloro-N-methoxy-N-methyl-1H-indole-2-carboxamide A mixture of 4-chloro-1H-indole-2-carboxylic acid (from Ryan Scientific, 1.0 g, 5.1 mmol), O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (2.9 g, 7.7 mmol) and triethylamine (3.6 mL, 26 mmol) in N,N-dimethylformamide (15 mL) was stirred at room temperature for 10 minutes. N,O-Dimethylhydroxylamine hydrochloride (0.75 g, 7.7 mmol) was added and the resulting suspension was stirred at room temperature overnight. The mixture was quenched with water and then extracted with EtOAc. The combined organic layers were dried over MgSO4, concentrated and purified on silica gel (eluting with 0-35% EtOAc in hexane) to give the desired product (0.35 g, 29%). LCMS calculated for C11H12ClN2O2(M+H)+: m/z=239.1; Found: 239.1.

24621-73-6 4-Chloro-1H-indole-2-carboxylic acid 90561, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Li, Yun-Long; Combs, Andrew P.; US2011/312979; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles