Category: 24985-85-1

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24985-85-1, 24985-85-1 Ethyl 5-hydroxyindole-2-carboxylate 90677, aindole-building-block compound, is more and more widely used in various fields.

24985-85-1, Ethyl 5-hydroxyindole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-hydroxyindole-2-carboxylic acid ethyl ester (14.2 g, 68.5 mmol) in DMF (150 mL) was added cesium carbonate (26.8 g, 82.3 mmol). The resulting mixture was stirred at room temperature for 20 min followed by the addition of allyl bromide (5.94 mL, 68.5 mmol). The reaction mixture was stirred at room temperature for 24 h. The reaction was diluted with ethyl acetate, washed with H2O, brine and dried (Na2SO4). The solvent was removed in vacua and the resulting crude product was purified by flash column chromatography on silica gel (0-20% EtOAc/hexanes) to give the desired material as solid (8.9 g, 52%). LC/MS (ES+) m/e 248 [M+H]+.

24985-85-1, 24985-85-1 Ethyl 5-hydroxyindole-2-carboxylate 90677, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; SmithKline Beecham Corporation; US6670388; (2003); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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The synthetic route of 24985-85-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24985-85-1,Ethyl 5-hydroxyindole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of ethyl 5-hydroxy-1 H-indole-2-carboxylate (0.25g, 1 .22 mmol) in acetone (3ml_) was added K2C03 (0.51 g, 3.66 mmol) and cyclopropylmethyl bromide (.24ml_, 2.44 mmol). The mixture was heated to reflux overnight. After cooling, the mixture wasfiltered through celite and concentrated under reduced pressure. The crude product was purified using flash chromatography on silica gel with 8:2 hexanes/ethyl acetate as eluent to give 131 mg of the title compound.

The synthetic route of 24985-85-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARISAN THERAPEUTICS INC.; PLEWE, Micheal; WHITBY, Landon; MCCORMACK, Kenneth; HENKEL, Gregory; BROWN, Eric; BOGER, Dale; SOKOLOVA, Nadezda; REDDY, Vidyasagar; (319 pag.)WO2016/160677; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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The synthetic route of 24985-85-1 has been constantly updated, and we look forward to future research findings.

24985-85-1, Ethyl 5-hydroxyindole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a cold (0 C.) mixture of ethyl-5-hydroxyindole-2-carboxylate (purchased at Biosynth, H-6350, 20.5 g, 1.0 eq.), (R)-1-benzyl-3-pyrrolidinol (23 g, 1.3 eq.) and tri-n-butylphosphine (58 mL, 2.0 eq.) was slowly added 1,1′-(azodicarbonyl)dipiperidine (50.4 g, 2.0 eq.) in several portions. The reaction mixture was stirred at room temperature overnight and then filtered off. The filtrate was concentrated in vacuo and diethylether was added. The precipitate was filtered off and the filtrate was concentrated in vacuo and purified on silica eluding with dichloromethane/methanol/ammoniac. One fraction was isolated and dried in vacuo, to yield 18 mg (49%) of the desired product as light yellow foam. MS (m/e): 365.5 (MH+, 100%).

The synthetic route of 24985-85-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Rodriguez Sarmiento, Rosa Maria; Taylor, Sven; US2007/123526; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles