With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2519-61-1,4-Chloroindole-3-acetic acid,as a common compound, the synthetic route is as follows.
General procedure: To a solution of carboxylic acid (0.8 mmol, 1.0 equiv) in CH2Cl2 (5 mL), DIPEA (1.0 mmol,1.3 equiv) and HATU (0.8 mmol, 1.0 equiv) were added, and the reaction mixture was stirred for 30 min, after which compound 7 (0.8 mmol, 1.0 equiv) in CH2Cl2 (2 mL) was added and stirred for 2 h. The mixture was filtered, the residue was washed with CH2Cl2, and then the solution was combined and concentrated. The residue was subjected to silica gel chromatography with petroleum ether/EtOAc (2:1) to give 13., 2519-61-1
2519-61-1 4-Chloroindole-3-acetic acid 100413, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Article; Liu, Jin; Chen, Yu; Li, Jing-Ya; Luo, Cheng; Li, Jia; Chen, Kai-Xian; Li, Xu-Wen; Guo, Yue-Wei; Marine Drugs; vol. 16; 3; (2018);,
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