Category: 2642-37-7

Ma, Yan-rong published the artcileAn LC-MS/MS analytical method for the determination of uremic toxins in patients with end-stage renal disease, Synthetic Route of 2642-37-7, the publication is Journal of Pharmaceutical and Biomedical Analysis (2020), 113551, database is CAplus and MEDLINE.

End-stage renal disease (ESRD) is the last stage of chronic kidney disease, characterized by the progressive accumulation of uremic toxins (UTs). Hemodialysis is the standard approach to remove UTs from the body. Creatinine and urea levels are important indexes of hemodialysis effectiveness, but the utility of those markers to estimate the removal of UTs, especially protein-binding UTs is limited. We developed an LC-MS/MS method for the quantification of UTs and to provide markers for evaluating hemodialysis effectiveness. These substances were extracted from serum samples after acetonitrile precipitation of protein and then separated on a HILIC column. The flow rate was 0.6 mL/min with a run time of 8.0 min for the neg. ion mode and pos. ion mode each. In this study 26 UTs were determined in normal subjects and in patients with ESRD before and after hemodialysis; serum levels were significantly higher in patients with ESRD than in subjects with normal renal function. A significant decrease in a variety of serum UTs were observed in patients after dialysis treatment, but no change in the levels of orotic acid, CMPF, kynurenic acid, p-cresol sulfate, phenyl-β-D-glucuronide, 4-ethylphenyl sulfate and 3-indolyl-β-D-glucopyranoside was found. These results show that some UTs could not be completely removed by hemodialysis. In addition, some biomarkers of different types of UTs are proposed for evaluating hemodialysis effectiveness.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Synthetic Route of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Tahata, Eiichi published the artcileMetabolism of indole, Product Details of C8H6KNO4S, the publication is Fukuoka Igaku Zasshi (1959), 4751-67, database is CAplus.

Isolated rabbit liver was perfused with heparinized blood containing indole. After 2-hrs. the perfuzate was deproteinized and treated with an aldehyde reagent. The BuOH extract of the colored substance was subjected to paper chromatography in a isoPrOH-H₂O system. The presence of indole, isatin, indican, anthranilic acid, and urochrome in the perfuzate was demonstrated by comparing their values with those of pure compounds The addition of flavine adenine dinucleotide to the perfuzate enlarged the size of the spots of these compounds except indole.

Fukuoka Igaku Zasshi published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C12H14IN, Product Details of C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sprince, Herbert published the artcileA modified Ehrlich benzaldehyde reagent for detection of indoles on paper chromatograms, Name: Potassium 1H-indol-3-yl sulfate, the publication is Journal of Chromatography (1960), 97-8, database is CAplus.

Indole chromatograms, sprayed first with a 2% solution of p-dimethylaminobenzaldehyde in 12.1N HCl, and, after 2-3 min., with 1% aqueous NaO₂, show deep-blue spots which appear immediately. Indican appears as an orange-brown spot and urea as a large deep-yellow spot. Colors developed with this reagent often persist for at least a month without fading.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C65H82N2O18S2, Name: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mueting, Dieter published the artcileDisturbances in protein metabolism in renal insufficiency, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Protides of the Biological Fluids (1962), 148-54, database is CAplus.

Studies were conducted in 129 patients with renal insufficiency resulting from glomerulonephritis and pyelonephritis. Total serum protein and albumin were decreased and α₁-, α₂– and γ-globulins were increased to an extent proportional to the degree of uremia. Tyrosine and tryptophan were elevated in serum, as well as their phenolic and indolyl catabolites. Increased concentrations of the latter were due not only to decreased urinary excretion but also to decrease oxidative processes. Impairment of oxidation reactions in uremia was also reflected by elevation of sulfate esters. Detoxication processes involving glucuronic acid, as well as sulfate conjugation, are impaired which further aggravates the toxic conditions produced by uremia. The most sensitive criteria of incipient renal insufficiency appeared to be the retention of creatinine and indican, obtained by analyses of their serum and urinary levels.

Protides of the Biological Fluids published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Matsuda, Kazuhiro published the artcileIndican as a feeding stimulant to the strawberry leaf beetle, Galerucella vittaticollis Baly attacking polygonaceous plants, Computed Properties of 2642-37-7, the publication is Applied Entomology and Zoology (1983), 18(4), 552-4, database is CAplus.

Feeding by G. vittaticollis was stimulated by indicans and K 3-indoxylsulfate at 0.001-0.1M, but not by indoxyl acetate, IAA, indigo, indole, or isatin. Indican was detected in Polygonum tinctorium leaves but not in leaves of other polygonaceous plants or strawberry leaves. Other beetles which feed on polygonaceous plant were not stimulated to feed by indican or related compounds

Applied Entomology and Zoology published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Computed Properties of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dittmann, Juergen published the artcileSeparation of phenols and phenol carboxylic acids by thin-layer chromatography on cellulose, Formula: C8H6KNO4S, the publication is Journal of Chromatography (1968), 32(4), 764-8, database is CAplus.

The Rf values and the detection limits are tabulated for the separation of 42 phenols and phenol carboxylic acids for 4 different developing systems by thin-layer chromatog. on cellulose. The use of 4 detection reagents is discussed. 42 references.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Formula: C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bryant, W. M. D. published the artcileFurther optical crystallographic studies of biochemical substances, Application of Potassium 1H-indol-3-yl sulfate, the publication is Microscope (1989), 37(3), 233-40, database is CAplus.

The optical crystallog. properties of 7 biochems. compounds were measured. Included are D-ribose and D-deoxyribose, structural elements of common nucleic acids; bilirubin, a blood porphyrin degradation product; glucuronic acid, K indoxyl sulfate (urine indican), and cholic acid, agents in human metabolic processes; and 3-flavonol, the parent substance of a series of bioflavonoids of plant origin, believed to be important in human nutrition. Aside from purely descriptive aspects, attention is given to techniques useful in improving precision of measurement and in extending the range of application of the polarizing microscope in the characterization of crystalline organic compounds

Microscope published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Application of Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bryan, George T. published the artcileA sensitive colorimetric method for the determination of urinary indoxyl sulfate (indican), HPLC of Formula: 2642-37-7, the publication is Analytical Biochemistry (1965), 10(1), 120-34, database is CAplus and MEDLINE.

A new, simple, rapid, and precise colorimetric method for urinary indoxyl sulfate (indican) was described. The method was based on preliminary column chromatography on a cation-exchange resin followed by diazotization and coupling. This method of analysis was compared with 2 other methods that have been used for indican analysis. It was found that 18 adult human subjects excreted 331 ± 144 micromoles (83 ± 36 mg.)/24 hrs. This quantity was several times greater than the amount generally believed to be present in human urine.

Analytical Biochemistry published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, HPLC of Formula: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Anraku, Takao published the artcileDecomposition of tryptophan by sulfurous acid salt. III. Isolation and structure of a greenish fluorescent product, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Yakugaku Zasshi (1966), 86(11), 1043-50, database is CAplus and MEDLINE.

cf. preceding abstracts The substance which shows strong green fluorescence in a solution of tryptophan with a sulfite was isolated and presumed to be dehydroindirubin-1′,2,3,3′-tetrasulfonic acid tetra-Na salt (I). I was considered to be an intermediate in the formation of a red precipitate of indirubin from tryptophan. The formation of I explains well the changes of yellow coloration, green fluorescence to precipitation, and quenching of fluorescence to yellow coloration. It was assumed that the process of this decomposition followed hydrolysis of tryptophan to form indole, serine, and alanine, oxidation of indole with concurrent addition of sulfurous acid to form dehydroindigodisulfonic acid and dehydroindirubintetrasulfonic acid, and formation of various decomposition products by catalytic oxidation in the presence of H or OH ion.

Yakugaku Zasshi published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Curzon, G. published the artcileA method for the determination of urinary indoxyl sulfate (indican), Product Details of C8H6KNO4S, the publication is Clinica Chimica Acta (1962), 657-63, database is CAplus and MEDLINE.

The method is based on the Ehrlich reaction of indoxyl sulfate with p-dimethylaminobenzaldehyde in acid solution When the solution is made alk., an intense red color is produced. This is extracted into petr. ether, in which it is yellow, and determined colorimetrically at 464 mμ. Urea is the only substance which interferes significantly. Thus, urine determinations are corrected for urea interference by multiplying by a factor of 1.18. Using this corrected factor, exptl. found recoveries of added K indoxyl sulfate from 10 urines (50 γ/ml. urine) varied from 94 to 108%. Normal subjects excreted 48.2 ± 19.1 mg. K indoxyl sulfate per 24 hrs.

Clinica Chimica Acta published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Product Details of C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles