Category: 2642-37-7

Sharma, S. K. published the artcileUrinary Indican in healthy Indian subjects, Product Details of C8H6KNO4S, the publication is Indian Journal of Physiology and Pharmacology (1977), 21(4), 342-6, database is CAplus and MEDLINE.

The average urinary excretion of indican was 40.4 mg/day in healthy Indian subjects. The average bacterial count in jejunal fluid was 1.96 × 10³/mL. There was a significant correlation between the indican excretion and total bacterial count.

Indian Journal of Physiology and Pharmacology published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C14H10O4, Product Details of C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

King, L. J. published the artcileThe metabolism of indole-2-¹⁴C in the rat, HPLC of Formula: 2642-37-7, the publication is Biochemical Journal (1966), 98(1), 266-77, database is CAplus and MEDLINE.

Indole-2-¹⁴C has been synthesized from formate-¹⁴C and ο-toluidine via N-for-myltoluidine-¹⁴C. When fed to rats, the ¹⁴C of indole-¹⁴C (dose 70-80 mg./kg. body weight) is fairly rapidly excreted, and in 2 days an average of 81% appears in the urine, 11% in the feces and 2.4% as CO₂ in the expired air. Radioactivity is excreted in the urine as indoxyl sulfate (50% of the dose), indoxyl glucuronide (11%), oxindole (1.4%), isatin (5-8%), 5-hydroxyoxindole (I) conjugates (3.1%), N-formylanthranilic acid (II) (0.5%), and unchanged indole (0.07%). The feces contain indoxyl sulfate (0.4% of the dose) and indole (0.2%), but the major metabolites have not been identified. Fed to rats with biliary cannulas, an average of 5.6% of a dose of indole-¹⁴C (20-60 mg./kg. body weight) is excreted in the bile in 2 days. Radioactivity is present as indoxyl sulfate (0.8% of dose) and I conjugates (0.6%). Rats further metabolize indoxyl into II and anthranilic acid, and oxindole into I. With rat liver microsomes plus supernatant under aerobic conditions, indole gives indoxyl, oxindole, possibly isatin, II, and anthranilic acid, but under anaerobic conditions gives only oxindole. Similarly, under aerobic conditions, oxindole gives I, anthranilic acid, and ο-aminophenylacetic acid. Indole is metabolized by 2 pathways, 1 via indoxyl to isatin, II, and anthranilic acid, and the other via oxindole to I and possibly to ο-aminophenylacetic and anthranilic acids. The following new compounds are described: 4-hydroxy-2-nitrophenylacetic acid, 3-, 4-, and 5-benzyloxy-2-nitrophenylacetic acid, 5-and 7-hydroxy-oxindoles, and 5-aminoacridine indoxyl sulfate.

Biochemical Journal published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, HPLC of Formula: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wellers, Georges published the artcileExchange between S³⁵ of ammonium sulfate and S³² of indoxylsulfate in aqueous solution, Formula: C8H6KNO4S, the publication is Compt. rend. (1960), 1140-2, database is CAplus.

A solution of indoxylsulfate, isolated from the urine of rabbits fed indole and methionine, was added to a solution of (NH₄)₂S³⁵O₄, and after 48 hrs. the mixture was chromatographed for 15 hrs. The radioactivity on the paper was determined before and after spraying with Ehrlich’s reagent. The radioactivity appeared only in the indoxylsulfate spot. The authors believed that the transfer of radioactivity takes place between the sulfate ions rather than between the S atoms. Although direct esterification of phenols by mineral sulfates would explain the appearance of radioactivity in the conjugated sulfates of the urine of animals administered Na₂S³⁵O₄, the fact that exchange between (NH₄)₂SO₄ and indoxylsulfate does occur would indicate that the former may not be the full explanation.

Compt. rend. published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C6H10O7, Formula: C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Matsumoto, Satoshi published the artcileChemicals inhibiting the growth of HeLa cells. II. Indole, anthranilic acid, and the related compounds, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Nippon Yakurigaku Zasshi (1959), 1065-8, database is CAplus.

The min. growth-inhibiting concentrations were: L-tryptophan 100 γ/mL., DL-5-hydroxytryptophan 200, K 3-indoleacetate 1000, 3-indolebutyric acid 250, indoxyl acetate 10, indican 500, dihydroxyindole 50, K indigodisulfonate >1000, K indigotetrasulfonate >1000, anthranilic acid 1000, 2-ureidobenzoic acid 500, 2-(thioureido)benzoic acid 200, 2-(carboxymethylamino)benzoic acid 500, 2,4-quinazolinediol 100, 2-amino-4-quinazolinol 10, 2-mercapto-4-quinazolinol 10, 5-hydroxyanthranilic acid 200, 5-hydroxy-2-ureidobenzoic acid 50, 2,4,6-quinazolinetriol 50, and 3-hydroxyanthranilic acid 200.

Nippon Yakurigaku Zasshi published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sano, Isamu published the artcileIndican and analogs in human urine. I. Millon’s reaction of indoxylsulfate at room temperature, SDS of cas: 2642-37-7, the publication is Seikagaku (1955), 153-6, database is CAplus.

Human urine showed pink red color with Millon’s reagent at room temperature The color tone was apparently different from that of phenols. To sep. a compound which showed the reaction, 200 l. urine was treated with C, the C extracted with a mixture of H₂O-NH₄OH-BuOH-MeOH (8:1:1:0.5). The extract was taken to dryness and extracted with 60% EtOH to remove uric acid. The residue was further extracted with BuOH, the extract was chromatographed on cellulose powder, and the fraction showing the Millon’s reaction was collected and purified by Amberlite IR-4B to yield 167 mg. of crystals. The crystals showed the Millon’s reaction and were identified to be K indoxylsulfate. 8-Quinolinol and 7-hydroxyindoleacetic acid (I) also showed the Millon’s reaction, but the presence of I was not detected in urines of 50 individuals when examined by paper chromatography.

Seikagaku published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, SDS of cas: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Masuda, Minoru published the artcileUrinary aromatic metabolites in schizophrenia, Category: indole-building-block, the publication is J. Nervous Mental Disease (1960), 125-33, database is CAplus.

The studies were carried out on 50 acute schizophrenic and 53 nonpsychotic subjects. Overnight urine specimens were prepared as recommended by Dalgleish (CA 51, 3715b) and analyzed by paper chromatography. In the schizophrenics the increased excretion of aromatic compounds was due to indolic, but not phenolic, substances, especially indoleacetic acid, 5-hydroxyindoleacetic acid, and indican. There was also increased excretion of urea. No metabolite was found regularly which would characterize the schizophrenic group.

J. Nervous Mental Disease published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Category: indole-building-block.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Van Rheenen, D. L. published the artcileQuantitative determination of urinary indoxyl sulfate (indican) and the total content of basic compounds in the feces of cattle in relation to hypomagnesemia, Quality Control of 2642-37-7, the publication is Nature (London, United Kingdom) (1966), 212(5067), 1269-70, database is CAplus and MEDLINE.

For the determination of indican, FeCl3 in concentrated HCl was used as oxidant. The method could detect 5 γ of indican. To 1 mL. of diluted urine or standard were added 2 mL. of 20% Cl3CCO2H, 1 mL. of 0.5% thymol, and 3 mL. of 0.34% FeCl3 in concentrated HCl. After incubation in boiling water for 20 min., the tubes were centrifuged at 4000 rpm. for 10 min. The yellow supernatant (0.4 mL.) was made up to 4 mL. with CHCl3 and the color intensity determined at 540 mμ. The total amount of amines and basic amino acids in extracts of feces were determined with ninhydrin. Urinary indican increased when feed was changed from hay to grain. This was an indication of increased bacterial metabolism in the gastrointestinal tract. After treatment resulting in hypomagnesemia, the total content of basic compounds in the feces decreased. This was due to absorption during passage through the gut. Under normal conditions, indican and basic amines normally formed in the colon are partly removed in the faces, partly detoxicated in the tissues and removed in the urine. In abnormal gastrointestinal function, larger amounts are absorbed. Hypomagnesemia may affect the destruction of these compounds in the tissues.

Nature (London, United Kingdom) published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C7H13NO2, Quality Control of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Haustein, Catherine published the artcileRoom-temperature phosphorescence of 3- and 5-substituted indoles, Safety of Potassium 1H-indol-3-yl sulfate, the publication is Talanta (1989), 36(11), 1065-8, database is CAplus and MEDLINE.

The room-temperature phosphorescence of indole and 13 substituted indoles on filter paper is reported. Cesium and iodide ions increase the emission intensity. In the presence of iodide, the excitation and emission wavelengths of indole are 279 and 440 nm, resp. The excitation and emission wavelengths of indoles with aliphatic groups in the 3-position are 288-289 and 443-449 nm, resp. Indoles with 3,5-substitution have excitation and emission wavelengths of 300-308 and 448-460 nm, resp. Indoxylsulfate and indoxyl-β-D-glucoside were the only indoles surveyed for which variations in the excitation and emission wavelengths depended on the heavy-atom ion present. These compounds had excitation wavelengths ranging from 288 to 388 nm, depending on which heavy-atom perturber was used. Emission wavelengths were 460-500 nm. Log-log plots of intensity vs. concentration were linear between 0.05 and 700 μg/mL for all the compounds studied, with detection limits in the nanogram range.

Talanta published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Safety of Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Hua published the artcileModified metabolites mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition, Safety of Potassium 1H-indol-3-yl sulfate, the publication is Journal of Chromatography A (2019), 80-87, database is CAplus and MEDLINE.

Modified metabolites play important roles in diagnostic monitoring, oxidative response and physiol. regulation. Comprehensive anal. methods are greatly needed for improving the coverage of modified metabolites and studying their physiol. function. Here, a novel nontargeted profiling method for mapping modified metabolites was developed by liquid chromatog.-high resolution mass spectrometry with full scan/all ion fragmentation/neutral loss (FS/AIF/NL) data acquisition. Modified metabolites were unbiasedly defined with less false pos. results by mixed standards verification. Thirteen types of modified metabolites in urine were analyzed at the same time, and 198 of 307 modified metabolites at pos. mode and 166 of 366 modified metabolites at neg. mode were putatively identified. The modified metabolites profiling method was applied for investigating the metabolic differences between the patients with breast cancer and health controls. As a result, many modified metabolites with glucuronidation, ribosylation and indole acetylation modification were significantly up-regulated in breast cancer and four modified metabolites including 7-methylguanosine, N₄-acetylcytidine, dihyroxy-1H-indole glucuronide I and indole-3-acetic acid-O-glucuronide were identified as potential biomarkers for the diagnose of breast cancer.

Journal of Chromatography A published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Safety of Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nakamura, Hiroshi published the artcilePerchloric acid, a fluorogenic spray reagent for tryptophan, tryptamine, peptides containing tryptophan and other 3-substituted indoles, Application In Synthesis of 2642-37-7, the publication is Journal of Chromatography (1978), 152(1), 167-74, database is CAplus.

When silica gel plates containing 3-substituted indoles (e.g., 3-methylindole, indole-3-acetic acid), tryptophan derivatives, tryptamine, and tryptophan-containing peptides (e.g., H-Trp-Gly-OH, H-Pro-Trp-OH, H-Lys-Trp-Lys-OH) were sprayed with 70% HClO₄, a strong yellow-orange fluorescence developed. Other indole derivatives did not give this fluorescence when sprayed with 70% HClO₄. 3-Substituted indoles can be detected at 40-850 pmole by this method.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Application In Synthesis of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles