Category: 2642-37-7

Nakamura, Hiroshi published the artcileSensitive and specific detection of tryptophan, tryptamine and N-terminal tryptophan peptides on thin-layer plates using a unique fluorogenic reaction with fluorescamine, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Journal of Chromatography (1978), 152(1), 153-65, database is CAplus.

Two sensitive and sp. methods were developed for the detection of tryptophan, tryptamine, N-terminal tryptophan peptides and other 3-(2-aminoethyl)-indoles on thin-layer plates in which the reaction is based on the unique fluorescence of the fluorescamine derivatives after treatment with HClO₄. The 1st method the compounds are separated on plates and reacted by dipping in acetone-n-hexane (1:4) containing fluorescamine, whereas in the 2nd method the compounds are first derivatized with fluorescamine at the origin of the plates by dipping in the solution and then separated When sprayed with 40% HClO₄, the fluorescamine derivatives appear as yellow-orange fluorescent spots. Certain 3,4-dihydroxyphenylethylamines and 3-methoxy-4-hydroxyphenylethylamines that have a free amino group in the side-chain also react, but they give a bluish fluorescence. Depending on the compounds, amounts of 1-800 pmole could be detected.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yates, C. G. published the artcileNew intermediates and dyes. X. Preparation and reactions of 2-n-alkylquinizarins, SDS of cas: 2642-37-7, the publication is Journal of the Chemical Society (1965), 626-9, database is CAplus.

2-Methylquinizarin was prepared by hydrolysis of 4-chloro-l-hydroxy-2 methylanthraquinone, or better, from 1,4-diamino-2-methylanthraquinone and aqueous alk. dithionite. 2-Propyl-, 2-butyl-, 2- hexyl-, 2-heptyl-, and 2-octylquinizarin were derived by the interaction of leucoquinizarin and an aliphatic aldehyde: this reaction appeared to be limited, as the use of decyl- and dodecylaldehyde gave quinizarin only. Inhibiting effects of the 2-n-alkyl groups in reactions with amines were examined Thus, 2-methyl-, propyl-, and butylquinizarin and aqueous NH₃ gave some disubstitution of the hydroxy groups, but with derivatives of longer alkyl chain, only monosubstitution occurred; MeNH₂ afforded yellow fluorescent products, probably formed by loss of water from 2-alkyl-1,4-bis(methylamino)anthraquinones. Whereas cyclohexylamine gave excellent yields of 2-alkyl-1,4-bis(cyclohexylamino)anthraquinones, disubstitution was inhibited in reactions with PhNH₂, which gave monoanilino derivatives

Journal of the Chemical Society published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C9H9ClN2, SDS of cas: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Hua published the artcileModified metabolites mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition, Safety of Potassium 1H-indol-3-yl sulfate, the publication is Journal of Chromatography A (2019), 80-87, database is CAplus and MEDLINE.

Modified metabolites play important roles in diagnostic monitoring, oxidative response and physiol. regulation. Comprehensive anal. methods are greatly needed for improving the coverage of modified metabolites and studying their physiol. function. Here, a novel nontargeted profiling method for mapping modified metabolites was developed by liquid chromatog.-high resolution mass spectrometry with full scan/all ion fragmentation/neutral loss (FS/AIF/NL) data acquisition. Modified metabolites were unbiasedly defined with less false pos. results by mixed standards verification. Thirteen types of modified metabolites in urine were analyzed at the same time, and 198 of 307 modified metabolites at pos. mode and 166 of 366 modified metabolites at neg. mode were putatively identified. The modified metabolites profiling method was applied for investigating the metabolic differences between the patients with breast cancer and health controls. As a result, many modified metabolites with glucuronidation, ribosylation and indole acetylation modification were significantly up-regulated in breast cancer and four modified metabolites including 7-methylguanosine, N₄-acetylcytidine, dihyroxy-1H-indole glucuronide I and indole-3-acetic acid-O-glucuronide were identified as potential biomarkers for the diagnose of breast cancer.

Journal of Chromatography A published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Safety of Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nakamura, Hiroshi published the artcilePerchloric acid, a fluorogenic spray reagent for tryptophan, tryptamine, peptides containing tryptophan and other 3-substituted indoles, Application In Synthesis of 2642-37-7, the publication is Journal of Chromatography (1978), 152(1), 167-74, database is CAplus.

When silica gel plates containing 3-substituted indoles (e.g., 3-methylindole, indole-3-acetic acid), tryptophan derivatives, tryptamine, and tryptophan-containing peptides (e.g., H-Trp-Gly-OH, H-Pro-Trp-OH, H-Lys-Trp-Lys-OH) were sprayed with 70% HClO₄, a strong yellow-orange fluorescence developed. Other indole derivatives did not give this fluorescence when sprayed with 70% HClO₄. 3-Substituted indoles can be detected at 40-850 pmole by this method.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Application In Synthesis of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nakamura, Hiroshi published the artcileSensitive and specific detection of tryptophan, tryptamine and N-terminal tryptophan peptides on thin-layer plates using a unique fluorogenic reaction with fluorescamine, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Journal of Chromatography (1978), 152(1), 153-65, database is CAplus.

Two sensitive and sp. methods were developed for the detection of tryptophan, tryptamine, N-terminal tryptophan peptides and other 3-(2-aminoethyl)-indoles on thin-layer plates in which the reaction is based on the unique fluorescence of the fluorescamine derivatives after treatment with HClO₄. The 1st method the compounds are separated on plates and reacted by dipping in acetone-n-hexane (1:4) containing fluorescamine, whereas in the 2nd method the compounds are first derivatized with fluorescamine at the origin of the plates by dipping in the solution and then separated When sprayed with 40% HClO₄, the fluorescamine derivatives appear as yellow-orange fluorescent spots. Certain 3,4-dihydroxyphenylethylamines and 3-methoxy-4-hydroxyphenylethylamines that have a free amino group in the side-chain also react, but they give a bluish fluorescence. Depending on the compounds, amounts of 1-800 pmole could be detected.

Journal of Chromatography published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yates, C. G. published the artcileNew intermediates and dyes. X. Preparation and reactions of 2-n-alkylquinizarins, SDS of cas: 2642-37-7, the publication is Journal of the Chemical Society (1965), 626-9, database is CAplus.

2-Methylquinizarin was prepared by hydrolysis of 4-chloro-l-hydroxy-2 methylanthraquinone, or better, from 1,4-diamino-2-methylanthraquinone and aqueous alk. dithionite. 2-Propyl-, 2-butyl-, 2- hexyl-, 2-heptyl-, and 2-octylquinizarin were derived by the interaction of leucoquinizarin and an aliphatic aldehyde: this reaction appeared to be limited, as the use of decyl- and dodecylaldehyde gave quinizarin only. Inhibiting effects of the 2-n-alkyl groups in reactions with amines were examined Thus, 2-methyl-, propyl-, and butylquinizarin and aqueous NH₃ gave some disubstitution of the hydroxy groups, but with derivatives of longer alkyl chain, only monosubstitution occurred; MeNH₂ afforded yellow fluorescent products, probably formed by loss of water from 2-alkyl-1,4-bis(methylamino)anthraquinones. Whereas cyclohexylamine gave excellent yields of 2-alkyl-1,4-bis(cyclohexylamino)anthraquinones, disubstitution was inhibited in reactions with PhNH₂, which gave monoanilino derivatives

Journal of the Chemical Society published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C9H9ClN2, SDS of cas: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sen, S. P. published the artcilePaper chromatography of plant-growth regulators and allied compounds, Formula: C8H6KNO4S, the publication is Physiologia Plantarum (1954), 98-108, database is CAplus.

The chromatog. behavior of a number of indole derivatives in several solvent systems is described, along with their detection by fluorescence in UV light and their color reactions with FeCl₃-HClO₄, p-dimethylaminobenzaldehyde, KNO₂-HNO₃, cinnamaldehyde-HCl, dichloroquinone chlorimide, and other reagents. The following compounds were tested: indole, 2-methylindole, 3-methylindole, 3-indolecarboxylic acid, 3-indoleacetic acid, 3-indolepropionic acid, 3-indolebutyric acid, 3-indolecarboxaldehyde, 3-indoleacetaldehyde, 3-indoleacetonitrile, 3-indolebutyronitrile, Et 3-indoleacetate, tryptophan, tryptamine, gramine, isatin, N-acetylisatin, dihydroxyindole, indican, indican glucoside, indoxylacetate, N-acetylindoxyl, indigotin, indigodisulfonate, indigotetrasulfonate, and indirubin. R_f values, as detected by spraying with bromocresol green, were also determined for a number of aromatic acids. These included 1-naphthaleneacetic acid; 2-naphthoxyacetic acid; phenylacetic acid; phenoxyacetic acid, and its 慰-chloro, p-chloro, 2,4-dichloro, and 3,4,5-trichloro derivatives; and benzoic acid and its following derivatives: 慰-bromo, m-bromo, p-bromo, 慰-chloro, m-chloro, p-chloro, 2,4-dichloro, 3,4-dichloro, 2,3,5-triiodo, m-hydroxy; p-hydroxy, 2,4-dihydroxy, 慰-amino, p-amino, 2,5-dinitro, 3,5-dinitro, 2-amino-5-chloro, and 2-chloro-5-nitro.

Physiologia Plantarum published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C9H7NO3, Formula: C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Karishin, A. P. published the artcileCondensation of 5-chloro-6-fluoroacenaphthenequinone with 3-hydroxythionaphthene, its derivatives, and indoxyl, HPLC of Formula: 2642-37-7, the publication is Zhurnal Obshchei Khimii (1964), 34(9), 306-8, database is CAplus.

Indigoid dyes of structure I were prepared, where X is S or NH, R¹ is H or Me, R² is H, or R¹ + R² is benzo, and R³ is H, Cl, or OEt. 5-Chloro-6- fluoroacenaphthene (10 g.) in 150 ml. HOAc was heated to 100掳, 50 g. Na₂Cr₂O₇ was added, heating continued 4 min., and the mixture poured into 300 ml. H₂O. The precipitate was filtered, washed, and heated twice with 300 ml. 6% NaHC0₃ solution on a boiling water bath for 40 min. 4,5,1,8-ClFC₁₀H₄(CO₂H)₂ (II), precipitated by acidifying the alk. solution with HCl, was filtered and dried to yield 3.1 g. colorless needles of II anhydride (III), m. 234-5掳 (HOAc). The filtrate from the isolation of III was treated twice with 50 ml. 25% NaHSO₃. The resulting compound was decomposed with HCl, and the mixture was boiled to remove SO₂, then cooled, filtered, and dried to give 3.41 g. 5-chloro-6-fluoronaphthenequinone (IV) golden yellow needles, m. 241-2. To 0.01 mole IV in 50 ml. boiling HOAc were added 0.01 mole 3-hydroxythionaphthene and 5 drops concentrated HCl, and the mixture was boiled 5 min., cooled, and filtered to give 88.2% I (R¹ = R² = R³ = H, X = S), m. 284-5掳(PhNO₂)₂, 位max. 492 and 535 m渭. Other I (X = S) were prepared similarly (R¹, R₂, R₃, % yield, m.p., and 位_max in 渭 (PhCl) given): H, H, Cl, 81.5, 375-6掳, 480 and 515; Me, H, Cl, 77.3, 334-5%, 482 and 517; H, H, OEt, 61.2, 271-2掳 460 and 496; R¹ + R² = benzo, H, 61.5, 337-8掳, 464 and 510. To 2.34 g. IV in 50 ml. boiling HOAc was added a filtered solution of 18.6 g. 7% indoxyl melt in 60 ml. 70% HOAc. The mixture was boiled 5 min., then cooled to give 2.6 g. (74.4%) I (R¹ = R² = R³ = H, X = NH), m. 324-5掳 (PhNO₂), 位_max 552 and 571 m渭.

Zhurnal Obshchei Khimii published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, HPLC of Formula: 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bergmann, Felix published the artcileDetermination of uric acid and its thio analogs in biological fluids, Computed Properties of 2642-37-7, the publication is Analytical Biochemistry (1965), 10(1), 73-85, database is CAplus and MEDLINE.

Uric acid and its thio derivatives were separated from plasma proteins by the use of Sephadex. Thiouric acids in plasma were determined spectrophotometrically. Uric acid analysis by enzymic oxidation was not disturbed by the presence of the 2- or 8-thio analog. On the other hand, separation of uric acid and its 6-thio derivative on an anion exchanger must precede determination of the former. The absorption spectra of the mercuric complexes of thiouric acids differed characteristically from the spectra of the free thio derivatives Analysis of thiouric acids in urine was based on the difference in absorbance between Hg(II)-free solutions and those containing the metal ion.

Analytical Biochemistry published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Computed Properties of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yu, Shun published the artcileStability of human serum albumin structure upon toxin uptake explored by small angle neutron scattering, COA of Formula: C8H6KNO4S, the publication is Polymer (2018), 175-183, database is CAplus.

The possible denaturation or tertiary structural changes of human serum albumin (HSA) upon adsorption of uremic toxin was investigated using small-angle neutron scattering (SANS). Calorimetric data in previous studies provided proof of binding between HSA and 2 classes of uremic toxins: (1) small-mol.-weight (SMW) toxins and (2) middle-mol.-weight (MMW) toxins. Polyacrylic acid, a representative polyelectrolyte of neg. net charge, was used as a model MMW toxin and 2 mols. [phenylacetic acid (PhAA) and indoxyl sulfate (IDS)] represented the SMW toxins. The present study found no proof of destabilization of the protein structure upon toxin uptake. Analyzing the structure factor of scattering intensities from high concentrated protein samples complexed with PhAA and IDS showed that interaction between native and complexed HSA was also not altered. However, a small effect of the net charge of HSA was found in the case of urea-modified proteins.

Polymer published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C11H15BFNO4, COA of Formula: C8H6KNO4S.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles