With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27018-76-4,1-Benzyl-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
1-benzyl-1 H-indole-3-carboxylic acid (1.4 g), tert-butyl piperazine- 1 -carboxylate (1.1 g)EDC (1.4 g), HOBt (1.0 g)And triethylamine (1.0 mL) were dissolved in dichloromethane (10 mL), And the mixture was stirred at room temperature for 19 hours.Water was added to the reaction solution, the mixture was extracted with dichloromethane and washed with saturated brine.The organic layer was dried over sodium sulfate,The solvent was evaporated under reduced pressure to obtain a residue,Purification by silica gel column chromatography (hexane-ethyl acetate), Tert-butyl 4- (1-benzyl-1 H-indole-3-carbonyl) piperazine- 1 – carboxylate1.5 g (yield 66%) was obtained., 27018-76-4
The synthetic route of 27018-76-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY; YANAGISAWA, KATSUHIKO; KAWAI, AKIYOSHI; (139 pag.)JP2017/171619; (2017); A;,
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