Category: 27034-51-1

27034-51-1, Ethyl 6-chloroindole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 2.3: B-Chloro-S-formyl-I H-indole^-carboxylic acid ethyl esterThe title compound is prepared according to a published literature procedure (see J. Med. Chem. 2005, 48, 995-1018.) A solution of beta-chloro-I H-indole^-carboxylic acid ethyl ester ( 5.0 g, 22.4 mmol) (commercially available from 3D Medical Systems Inc.) and POCI3 (2.46 mL, 26.8 mmol) in DMF (15 ml_) is heated at 50 0C for 28h. After completion, the reaction mixture is quenched by aqueous NaHCO3, Et2O is added and the organic layer is washed with brine, dried over MgSO4 and evaporated in vacuo. Silica gel flash chromatography of the residue affords the title compound as a colorless powder; ES-MS: M- = 250.1 ; HPLC: AtRet = 4.67 min., 27034-51-1

Big data shows that 27034-51-1 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2008/119741; (2008); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles