Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of 2,4-Bis(2-phenylpropan-2-yl)phenol, 2772-45-4, Name is 2,4-Bis(2-phenylpropan-2-yl)phenol, molecular formula is C24H26O, belongs to indole-building-block compound. In a document, author is Liu, Ruixing, introduce the new discover.
The Summary of main observation and conclusion A Rh-III/Ag-I relay-catalyzed C(sp(2))-H coupling of indoles with triarylhexahydrotriazine (THT) is reported in this context. Upon merging Rh-III-catalyzed C(sp(2))-H bond activation and silver promoted THT dissociation, an efficient indole’s C3 aminomethylation protocol is uncovered, providing C3 aminomethyl indoles in good yields and exhibiting potential applications for the synthesis of complicated bioactive compounds. We revealed the C3-selectivity of this reaction through a detailed mechanistic investigation. Meanwhile, during the examination of the reaction conditions, we discovered another [4+2] cycloaddition pathway to afford tetrahydro-indolo[3,2-c]quinoline scaffold products via silver or Lewis acid catalysis.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2772-45-4. Safety of 2,4-Bis(2-phenylpropan-2-yl)phenol.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles