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Ascorbic acid as an initiator for the direct C-H arylation of (hetero)arenes with anilines nitrosated in situ

Ascorbic acid (vitaminC) has been used as a radical initiator in a metal-free direct C-H arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitaminC to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. Notably, neither heating nor irradiation is required. This procedure is mild, operationally simple, and constitutes a greener approach to arylation. Copyright

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Reference£º
Imidazolidine – Wikipedia,
Imidazolidine | C3H8N2418 – PubChem

Final Thoughts on Chemistry for 1-Aminohydantoin hydrochloride

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Synthetic receptors for neutral nitro derivatives

Different arylurea-based receptors with similar substitution pattern and one guanidine-based receptor were synthesised and studied concerning their binding capability towards the title functional group; specific binding of neutral nitro groups is revealed with relatively high binding constants in DMSO ranging from 470 to 1370 M-1 for urea and 730-990 M-1 for guanidine-based binding partners.

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Reference£º
Imidazolidine – Wikipedia,
Imidazolidine | C3H8N2413 – PubChem