With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28737-33-9,3-Bromoindole-2-carboxylic Acid,as a common compound, the synthetic route is as follows.
General procedure: To a suspension of 4-methoxyindole-2-carboxylic acid (6, 93.7 mg, 0.49 mmol) in anhydrous dichloromethane (2 mL) was added at room temperature (R)-1-(1-naphthyl)ethylamine (19, 88 mg, 0.52 mmol). The mixture was cooled to 0 C and N-hydroxybenzotriazole (HOBt, 70.3 mg, 0.52 mmol), N-ethyl-N’-(3-dimethylaminopropyl)carbodiimide (EDCI, 80.7 mg, 0.52 mmol) and triethylamine (52.6 mg, 0.52 mmol) were added. The reaction mixture was stirred for 1 h at 0 C and then at room temperature for 5 h. Water was added, the mixture was extracted with dichloromethane, the organic extract was dried over sodium sulfate and the solvent was removed under vacuum. The residue was purified by flash chromatography on silica gel (ethyl acetate/heptane 1:4 then 2:3), providing compound 20 as a white powder (153 mg, 91%);
28737-33-9, The synthetic route of 28737-33-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kiefer, Lionel; Beaumard, Floriane; Gorojankina, Tatiana; Faure, Helene; Ruat, Martial; Dodd, Robert H.; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 554 – 569;,
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