Category: 29046-78-4

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of the American Chemical Society called Sulfonate Versus Sulfonate: Nickel and Palladium Multimetallic Cross-Electrophile Coupling of Aryl Triflates with Aryl Tosylates, Author is Kang, Kai; Huang, Liangbin; Weix, Daniel J., which mentions a compound: 29046-78-4, SMILESS is COCCOC.Cl[Ni]Cl, Molecular C4H10Cl2NiO2, Electric Literature of C4H10Cl2NiO2.

While phenols are frequent and convenient aryl sources in cross-coupling, typically as sulfonate esters, the direct cross-Ullmann coupling of two different sulfonate esters is unknown. We report here a general solution to this challenge catalyzed by a combination of Ni and Pd with Zn reductant and LiBr as an additive [e.g., 4-methoxyphenyl triflate + Ph tosylate → 4-methoxybiphenyl (76%)]. The reaction has broad scope, as demonstrated in 33 examples (65% ± 11% average yield). Mechanistic studies show that Pd strongly prefers the aryl triflate, the Ni catalyst has a small preference for the aryl tosylate, aryl transfer between catalysts is mediated by Zn, and Pd improves yields by consuming arylzinc intermediates.

Different reactions of this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)Electric Literature of C4H10Cl2NiO2 require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application of 29046-78-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Transition Metal Compounds of Pyridine-Amide-Functionalized Carbene Ligands: Synthesis, Structure, and Electrocatalytic Properties in Proton Reduction. Author is Luo, Siyuan; Siegler, Maxime A.; Bouwman, Elisabeth.

Three pyridyl-amide substituted (benz)imidazolium salts H2L1Cl, H2L2Cl and H2L3Cl were synthesized and successfully employed as ligand precursors for the syntheses of novel nickel(II) and cobalt(III) complexes. The compounds H2L1Cl and H2L2Cl are precursors to tetradentate ligands and differ in the nature of the N-heterocyclic carbene (NHC) functionality, being imidazole-based and benzimidazole-based, resp. The ligand precursor H2L3Cl resembles H2L1Cl, but with one of the pyridyl groups replaced with a benzyl group, thus yielding a potential tridentate ligand. The nickel(II) compounds [Ni(L1)]Cl and [Ni(L2)]PF6 were obtained, bearing tetradentate ligands comprising an amidate and two pyridine nitrogen donor atoms and an (NHC) carbon donor. Single crystal x-ray crystallog. revealed that the nickel ions in both compounds are in slightly distorted square-planar geometries. Reactions of cobalt salts with the ligands H2L1Cl and H2L3Cl resulted in the cobalt(III) compounds [Co(L1)2]Cl and [Co(L3)2]PF6; the cobalt ions in both complexes are in octahedral geometries, bound by two tridentate ligands in a meridional binding mode, with two dangling pyridine and benzyl groups, resp. The four compounds show electrocatalytic activity in proton reduction in DMF solutions in presence of acetic acid; their activity is compared using cyclic voltammetry and quantified with gas chromatog.

Different reactions of this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)Application of 29046-78-4 require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application of 29046-78-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Transition Metal Compounds of Pyridine-Amide-Functionalized Carbene Ligands: Synthesis, Structure, and Electrocatalytic Properties in Proton Reduction. Author is Luo, Siyuan; Siegler, Maxime A.; Bouwman, Elisabeth.

Three pyridyl-amide substituted (benz)imidazolium salts H2L1Cl, H2L2Cl and H2L3Cl were synthesized and successfully employed as ligand precursors for the syntheses of novel nickel(II) and cobalt(III) complexes. The compounds H2L1Cl and H2L2Cl are precursors to tetradentate ligands and differ in the nature of the N-heterocyclic carbene (NHC) functionality, being imidazole-based and benzimidazole-based, resp. The ligand precursor H2L3Cl resembles H2L1Cl, but with one of the pyridyl groups replaced with a benzyl group, thus yielding a potential tridentate ligand. The nickel(II) compounds [Ni(L1)]Cl and [Ni(L2)]PF6 were obtained, bearing tetradentate ligands comprising an amidate and two pyridine nitrogen donor atoms and an (NHC) carbon donor. Single crystal x-ray crystallog. revealed that the nickel ions in both compounds are in slightly distorted square-planar geometries. Reactions of cobalt salts with the ligands H2L1Cl and H2L3Cl resulted in the cobalt(III) compounds [Co(L1)2]Cl and [Co(L3)2]PF6; the cobalt ions in both complexes are in octahedral geometries, bound by two tridentate ligands in a meridional binding mode, with two dangling pyridine and benzyl groups, resp. The four compounds show electrocatalytic activity in proton reduction in DMF solutions in presence of acetic acid; their activity is compared using cyclic voltammetry and quantified with gas chromatog.

Different reactions of this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)Application of 29046-78-4 require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Ir/Ni photoredox dual catalysis with heterogeneous base enabled by an oscillatory plug flow photoreactor, published in 2020-10-16, which mentions a compound: 29046-78-4, Name is Nickel(II) chloride ethylene glycol dimethyl ether complex, Molecular C4H10Cl2NiO2, SDS of cas: 29046-78-4.

Continuous flow reactor technol. has a proven track record in enabling photochem. transformations. However, transfer of a photochem. batch process to a flow protocol often remains elusive, especially when solid reagents or catalysts are employed. In this work, application of an oscillatory plug flow photoreactor enabled a heterogeneous MacMillan-type C(sp2)-C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)-C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity (0.87 g/h).

The article 《Ir/Ni photoredox dual catalysis with heterogeneous base enabled by an oscillatory plug flow photoreactor》 also mentions many details about this compound(29046-78-4)SDS of cas: 29046-78-4, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zarate, Cayetana; Yang, Haifeng; Bezdek, Mate J.; Hesk, David; Chirik, Paul J. published an article about the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4,SMILESS:COCCOC.Cl[Ni]Cl ).HPLC of Formula: 29046-78-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:29046-78-4) through the article.

The synthesis and spectroscopic characterization of a family of Ni-X (X = Cl, Br, I, H) complexes supported by the bulky α-diimine chelate N,N’-bis(1R,2R,3R,5S)-(-)-isopinocampheyl-2,3-butanediimine (ipcADI) are described. Diimine-supported, three-coordinate Ni(I)-X complexes are proposed as key intermediates in a host of catalytic transformations such as C-C and C-heteroatom cross-coupling and C-H functionalization but have until now remained synthetically elusive. A combination of structural, spectroscopic, electrochem., and computational studies were used to establish the electronic structure of each monomeric [(ipcADI)NiX] (X = Cl, Br, I) complex as a Ni(I) derivative supported by a redox-neutral α-diimine chelate. The dimeric Ni hydride, [(ipcADI)Ni(μ2-H)]2, was prepared and characterized by x-ray diffraction; however, magnetic measurements and 1H NMR spectroscopy support monomer formation at ambient temperature in THF solution This Ni hydride was used as a precatalyst for the H isotope exchange (HIE) of C-H bonds in arenes and pharmaceuticals. By virtue of the multisite reactivity and high efficiency, the new Ni precatalyst provided unprecedented high specific activities (50-99 Ci/mmol) in radiolabeling, meeting the threshold required for radioligand binding assays. Use of air-stable and readily synthesized Ni precursor, [(ipcADI)NiBr2], broad functional group tolerance, and compatibility with polar protic solvents are addnl. assets of the Ni-catalyzed HIE method.

The article 《Ni(I)-X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals》 also mentions many details about this compound(29046-78-4)HPLC of Formula: 29046-78-4, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones.Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex.

Acyl radicals have been generated from α-keto acids RC(O)C(O)OH (R = Ph, furan-2-yl, Me, etc.) using inexpensive and com. available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins R1CH=CH(R3)R2 [R1 = H, Me, Ph, 4-fluorophenyl, etc.; R2 = H, Me, C(O)OCH3, C(O)OC2H5; R3 = H, C(O)Ph, Boc, (cyclohexyloxy)carbonyl, C(O)OC2H5] or coupled with aryl halides ArX (Ar = Ph, 6-(trifluoromethyl)pyridin-2-yl, quinolin-3-yl, etc.) via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones ArC(O)R and RC(O)CH(R1)CH(R3)R2. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.

After consulting a lot of data, we found that this compound(29046-78-4)Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ) is researched.SDS of cas: 29046-78-4.Li, Haoyang; Long, Jiao; Li, Yuqiang; Wang, Wang; Pang, Hailiang; Yin, Guoyin published the article 《Nickel-Catalyzed Regioselective Arylboration of Conjugated Dienes》 about this compound( cas:29046-78-4 ) in European Journal of Organic Chemistry. Keywords: allyl alc arylated preparation arylboration conjugated diene oxidation. Let’s learn more about this compound (cas:29046-78-4).

The nickel-catalyzed arylboration of conjugated dienes CH2:CRCH:CH2 with aryl bromides ArBr and B2pin2, yielding (E)-ArCH2CR:CHCH2OH after oxidation, is reported. Good 1,4-regioselectivity and (E)-stereoselectivity were obtained using isoprene, together with very good 1,2-regioselectivity and (E)-stereoselectivity using 1-arylbutadienes. The high reactivity and selectivity of this process were dependent on the use of the appropriate nitrogen-based ligand. Moreover, wide functional group tolerance was observed under mild reaction conditions. This protocol provides a path to allyl or homoallyl boronic ester derivatives starting from 1,3-dienes, aryl bromides, and B2pin2. The downstream transformation of allyl boronic esters was also achieved, suggesting a strategy for the diastereoselective 1,2-difunctionalization of isoprene and demonstrating the potential for the synthesis of complex mols.

After consulting a lot of data, we found that this compound(29046-78-4)SDS of cas: 29046-78-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Generation and oxidative reactivity of a Ni(II) superoxo complex via ligand-based redox non-innocence, published in 2020, which mentions a compound: 29046-78-4, Name is Nickel(II) chloride ethylene glycol dimethyl ether complex, Molecular C4H10Cl2NiO2, Related Products of 29046-78-4.

Metal ligand cooperativity is a powerful strategy in transition metal chem. This type of mechanism for the activation of O2 is best exemplified by heme centers in biol. systems. While aerobic oxidations with Fe and Cu are well precedented, Ni-based oxidations are frequently less common due to less-accessible metal-based redox couples. Some Ni enzymes utilize special ligand environments for tuning the Ni(II)/(III) redox couple such as strongly donating thiolates in Ni superoxide dismutase. A recently characterized example of a Ni-containing protein, however, suggests an alternative strategy for mediating redox chem. with Ni by utilizing ligand-based reducing equivalent to enable oxygen binding. While this mechanism has little synthetic precedent, authors show here that Ni complexes of the redox-active ligand tBu,TolDHP (tBu,TolDHP = 2,5-bis((2-t-butylhydrazono)(p-tolyl)methyl)-pyrrole) activate O2 to generate a Ni(II) superoxo complex via ligand-based electron transfer. This superoxo complex is competent for stoichiometric oxidation chem. with alcs. and hydrocarbons. This work demonstrates that coupling ligand-based redox chem. with functionally redox-inactive Ni centers enables oxidative transformations more commonly mediated by metals such as Fe and Cu.

After consulting a lot of data, we found that this compound(29046-78-4)Related Products of 29046-78-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of Nickel(II) chloride ethylene glycol dimethyl ether complex. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Photoredox-Catalysis-Modulated, Nickel-Catalyzed Divergent Difunctionalization of Ethylene. Author is Li, Jiesheng; Luo, Yixin; Cheo, Han Wen; Lan, Yu; Wu, Jie.

Herein, the use of ethylene feedstock and com. available aryl halides was demonstrated to accomplish the divergent synthesis of 1,2-diarylethanes, 1,4-diarylbutanes, or 2,3-diarylbutanes in a highly selective fashion through the synergistic combination of nickel and photoredox catalysis. Mechanistic studies suggested that the observed selectivity was due to different active states of Ni(I) and Ni(0) modulated by Ru- and Ir-based photoredox catalysts, resp. The ability to access different organometallic oxidation states via photoredox catalysis promises to inspire new perspectives for synergistic transition-metal-catalyzed divergent synthesis.

After consulting a lot of data, we found that this compound(29046-78-4)Quality Control of Nickel(II) chloride ethylene glycol dimethyl ether complex can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 29046-78-4, is researched, SMILESS is COCCOC.Cl[Ni]Cl, Molecular C4H10Cl2NiO2Journal, Applied Organometallic Chemistry called Polynuclear (α-diimine) nickel(II) complex as catalyst for ethylene oligomerization, Author is Li, Dan; Ma, Fengmin; Guo, Lijun; Huang, Jin; Zhang, Yu; Li, Feng; Li, Cuiqin, the main research direction is ethylene oligomerization polynuclear diimine nickel complex catalyst synthesis.Computed Properties of C4H10Cl2NiO2.

Late transition metal catalysts with single or multiple active centers have great attention in the ethylene oligomerization application owing to their unique properties. A new polynuclear (α-diimine) nickel(II) complex (PS-Ni complex) bearing the conjugated poly(Schiff-base) ligand (PS-ligand) was synthesized. The structures and the composition of the PS-ligand and the PS-Ni complex were characterized by Fourier transform IR (FTIR) anal., X-ray diffraction (XRD), XPS, SEM, thermogravimetric (TG) anal., NMR (NMR) and gel permeation chromatog. (GPC). The PS-Ni complex was used as precatalyst in ethylene oligomerization combined with methylaluminoxane (MAO) and has good catalytic activity for ethylene oligomerization under mild conditions. Compared with the corresponding mononuclear (α-diimine) nickel(II) complex, the PS-Ni complex showed higher activity of 17.62 × 105 g/(mol Ni·h), and the main products were C4 and C6 olefins in cyclohexane when the dosage of precatalyst was 2μmol, the Al/Ni molar ratio was 500, the ethylene pressure was 0.5 MPa, the reaction time was 60 min, and the reaction temperature was 25°C. The main oligomers were α-olefins, and the selectivity was up to 98.68%, due to the more electron-deficient catalytic centers of the conjugated structure of poly(Schiff-base) ligand.

After consulting a lot of data, we found that this compound(29046-78-4)Computed Properties of C4H10Cl2NiO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles