Category: 29046-78-4

Product Details of 29046-78-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about A Germylene Supported by Two 2-Pyrrolylphosphane Groups as Precursor to PGeP Pincer Square-Planar Group 10 Metal(II) and T-Shaped Gold(I) Complexes. Author is Cabeza, Javier A.; Fernandez, Israel; Fernandez-Colinas, Jose M.; Garcia-Alvarez, Pablo; Laglera-Gandara, Carlos J..

An efficient synthesis of 2-di-tert-butylphosphinomethylpyrrole (HpyrmPtBu2), by treating 2-dimethylaminomethylpyrrole (HpyrmNMe2) with tBu2PH at 135° in the absence of any solvent, has allowed the preparation of the new PGeP germylene Ge(pyrmPtBu2)2 (1), by treating [GeCl2(dioxane)] with LipyrmPtBu2, in which the Ge atom is stabilized by intramol. interactions with one (solid state) or both (solution) of its phosphine groups. Reactions of germylene 1 with Group 10 metal dichlorido complexes containing easily displaceable ligands have led to [MCl{κ3P,Ge,P-GeCl(pyrmPtBu2)2}] [M = Ni (2), Pd (3), Pt (4)], which have an unflawed square-planar metal environment. Treatment of germylene 1 with [AuCl(tht)] (tht = tetrahydrothiophene) rendered [Au{κ3P,Ge,P-GeCl(pyrmPtBu2)2}] (5), which is a rare case of a T-shaped gold(I) complex. The hydrolysis of 5 gave the linear gold(I) derivative [Au(κP-HpyrmPtBu2)2]Cl (6). Complexes 2-5 contain a PGeP pincer chloridogermyl ligand that arises from the insertion of the Ge atom of germylene 1 into a M-Cl bond of the corresponding metal reagent. The bonding in these mols. has been studied by DFT/NBO/QTAIM calculations These results demonstrate that the great flexibility of germylene 1 makes it a better precursor to PGeP pincer complexes than the previously known germylenes of this type.

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C4H10Cl2NiO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Chemistry Informer Libraries: Conception, Early Experience, and Role in the Future of Cheminformatics. Author is Dreher, Spencer D.; Krska, Shane W..

A review with new data. The synthetic chem. literature traditionally reports the scope of new methods using simple, nonstandardized test mols. that have uncertain relevance in applied synthesis. In addition, published examples heavily favor pos. reaction outcomes, and failure is rarely documented. In this environment, synthetic practitioners have inadequate information to know whether any given method is suitable for the task at hand. Moreover, the incomplete nature of published data makes it poorly suited for the creation of predictive reactivity models via machine learning approaches. In 2016, we reported the concept of chem. informer libraries as standardized sets of medium- to high-complexity substrates with relevance to pharmaceutical synthesis as demonstrated using a multidimensional principle component anal. (PCA) comparison to the physicochem. properties of marketed drugs. We showed how informer libraries could be used to evaluate leading synthetic methods with the complete capture of success and failure and how this knowledge could lead to improved reaction conditions with a broader scope with respect to relevant applications. In this Account, we describe the progress made and lessons learned in subsequent studies using informer libraries to profile eight addnl. reaction classes. Examining broad trends across multiple types of bond disconnections against a standardized chem. “”measuring stick”” has enabled comparisons of the relative potential of different methods for applications in complex synthesis and has identified opportunities for further development. Furthermore, the powerful combination of informer libraries and 1536-well-plate nanoscale reaction screening has allowed the parallel evaluation of scores of synthetic methods in the same experiment and as such illuminated an important role for informers as part of a larger data generation work-flow for predictive reactivity modeling. Using informer libraries as problem-dense, strong filters has allowed broad sets of reaction conditions to be narrowed down to those that display the highest tolerance to complex substrates. These best conditions can then be used to survey broad swaths of substrate space using nanoscale chem. approaches. Our experiences and those of our collaborators from several academic laboratories applying informer libraries in these contexts have helped us identify several areas for potential improvements to the approach that would increase their ease of use, utility in generating interpretable results, and resulting uptake by the broader community. As we continue to evolve the informer library concept, we believe it will play an ever-increasing role in the future of the democratization of high-throughput experimentation and data science-driven synthetic method development.

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Electrochemical Nozaki-Hiyama-Kishi Coupling: Scope, Applications, and Mechanism, the main research direction is allylic alc preparation electrochem; vinyl bromide aldehyde Nozaki Hiyama Kishi coupling chromium catalyst; redox active ester aldehyde Nozaki Hiyama Kishi coupling chromium.Name: Nickel(II) chloride ethylene glycol dimethyl ether complex.

One of the most oft-employed methods for C-C bond formation involving the coupling of vinyl-halides such as, 1-bromohex-1-ene, 1-bromocyclohept-1-ene, 2-(2,2-dibromoethenyl)furan, etc. with aldehydes RCHO (R = 4-chlorobutyl, 2-phenylethyl, 2-(5-methylfuran-2-yl)propyl, etc.) catalyzed by Ni and Cr (Nozaki-Hiyama-Kishi, NHK) has been rendered more practical using an electroreductive manifold. Although early studies pointed to the feasibility of such a process, those precedents were never applied by others due to cumbersome setups and limited scope. Here, a carefully optimized electroreductive procedure can enable a more sustainable approach to NHK, even in an asym. fashion on highly complex medicinally relevant systems. The e-NHK can even enable non-canonical substrate classes, such as redox-active esters I (R1 = 3-phenylpropyl, (3,4,5-trimethoxyphenyl)methyl, 1-[(tert-butoxy)(oxo)methane]azetidin-3-yl, etc.), to participate with low loadings of Cr when conventional chem. techniques fail. A combination of detailed kinetics, cyclic voltammetry, and in situ UV-vis spectroelectrochem. of these processes illuminates the subtle features of this mechanistically intricate process.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ) is researched.Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex.Ding, Decai; Lan, Yun; Lin, Zhiyang; Wang, Chuan published the article 《Synthesis of gem-Difluoroalkenes by Merging Ni-Catalyzed C-F and C-C Bond Activation in Cross-Electrophile Coupling》 about this compound( cas:29046-78-4 ) in Organic Letters. Keywords: gem difluoroalkene preparation carbon fluoride carbon carbon activation; regioselective nickel catalyzed cross electrophile coupling; cyclobutanone oxime ester trifluoromethyl alkene coupling radical reaction. Let’s learn more about this compound (cas:29046-78-4).

By merging C-F and C-C bond activation in the cross-electrophile coupling, we developed an efficient cyanide-free synthesis of diverse functional-group-rich cyano-substituted gem-difluoroalkenes using cyclobutanone oxime esters and trifluoromethyl alkenes as precursors. Notably, this Ni-catalyzed reaction is bestowed with broad substrate scope, low catalyst loading, complete regioselectivities, and high tolerance of a wide range of sensitive functional groups. Preliminary mechanistic studies indicate that an iminyl radical-initiated C-C bond cleavage is involved in the reaction pathway.

There are many compounds similar to this compound(29046-78-4)Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: 29046-78-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Harnessing Alkylpyridinium Salts as Electrophiles in Deaminative Alkyl-Alkyl Cross-Couplings. Author is Plunkett, Shane; Basch, Corey H.; Santana, Samantha O.; Watson, Mary P..

A Negishi cross-coupling of alkylpyridinium salts and alkylzinc halides has been developed. This is the first example of alkyl-alkyl bond formation via cross-coupling of an alkyl amine derivative with an unactivated alkyl group, and allows both primary and secondary alkylpyridinium salts to react with primary alkylzinc halides with high functional group tolerance. When combined with formation of the pyridinium salts from primary amines, this method enables the noncanonical transformation of NH2 groups into a wide range of alkyl substituents with broad functional group tolerance.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Nickel-Catalyzed Synthesis of Dialkyl Ketones from the Coupling of N-Alkyl Pyridinium Salts with Activated Carboxylic Acids. Author is Wang, Jiang; Hoerrner, Megan E.; Watson, Mary P.; Weix, Daniel J..

While ketones are among the most versatile functional groups, their synthesis remains reliant upon reactive and low-abundance starting materials. In contrast, amide formation is the most-used bond-construction method in medicinal chem. because the chem. is reliable and draws upon large and diverse substrate pools. A new method for the synthesis of ketones is presented here that draws from the same substrates used for amide bond synthesis: amines and carboxylic acids. A nickel terpyridine catalyst couples N-alkyl pyridinium salts with in situ formed carboxylic acid fluorides or 2-pyridyl esters under reducing conditions (Mn metal). The reaction has a broad scope, as demonstrated by the synthesis of 35 different ketones bearing a wide variety of functional groups with an average yield of 60±16%. This approach is capable of coupling diverse substrates, including pharmaceutical intermediates, to rapidly form complex ketones.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: 29046-78-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Quantifying the Interdependence of Metal-Ligand Covalency and Bond Distance using Ligand K-edge XAS. Author is Lee, Kyounghoon; Blake, Anastasia V.; Donahue, Courtney M.; Spielvogel, Kyle D.; Bellott, Brian J.; Daly, Scott R..

Bond distance is a common structural metric used to assess changes in metal-ligand bonds, but it is not clear how sensitive changes in bond distances are with respect to changes in metal-ligand covalency. Here we report ligand K-edge XAS studies on Ni and Pd complexes containing different phosphorus(III) ligands. Despite the large number of electronic and structural permutations, P K-edge pre-edge peak intensities reveal a remarkable correlation that spectroscopically quantifies the linear interdependence of covalent M-P σ bonding and bond distance. Cl K-edge studies conducted on many of the same Ni and Pd compounds revealed a poor correlation between M-Cl bond distance and covalency, but a strong correlation was established by analyzing Cl K-edge data for Ti complexes with a wider range of Ti-Cl bond distances. Together these results establish a quant. framework to begin making more accurate assessments of metal-ligand covalency using bond distances from readily-available crystallog. data.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and structural characterization of nickel(II) complexes of 20-membered macrocyclic rings bearing chelating bis(N-heterocyclic carbene) ligands, published in 2019-11-15, which mentions a compound: 29046-78-4, mainly applied to macrocyclic ring imidazolidene heterocyclic carbene nickel preparation crystal structure; crystal mol structure macrocyclic imidazolidene NHC carbene nickel complex; Suzuki coupling macrocyclic imidazolidene carbene nickel catalyzed, Reference of Nickel(II) chloride ethylene glycol dimethyl ether complex.

20-Membered macrocyclic rings (Lbenz and Limid) containing two amine moieties and two N-heterocyclic carbene (NHC) moieties coordinate in a κ2 coordination mode to Ni(II) through the NHC moieties. Complexes 3a and 3b were synthesized by generating free carbenes in situ from bis-benzimidazolium bromide salts and subsequent addition of one equivalent of [Ni(DME)X2] (X = Cl, Br) at 25°. Free carbenes of 20-membered macrocyclic ligands Lbenz and Limid can be generated in situ in THF-d8 and characterized by 1H and 13C NMR spectroscopy. 3B can also be synthesized by treatment of silver(I)-bis(NHC) complex 2a with one equivalent of [NiBr2(DME)] in refluxing methylene chloride for 20 h affording yields of up to 70%. Complexes 3a and 3b were characterized by x-ray diffraction. [NiI2(Lbenz)] 5c was prepared by halogen exchange of 3a or 3b with NaI at 25°. Ni complexes of Limid can be prepared and characterized in situ but cannot be isolated cleanly from the reaction mixtures The cis and trans isomers of [NiCl2(Limid)] (4a and 4b) and the bromide derivative 4c were characterized by x-ray crystallog. by judicious selection of individual, high-quality crystals obtained from crude reaction mixtures

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Organic Chemistry called Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides, Author is Biswas, Soumik; Qu, Bo; Desrosiers, Jean-Nicolas; Choi, Younggi; Haddad, Nizar; Yee, Nathan K.; Song, Jinghua J.; Senanayake, Chris H., which mentions a compound: 29046-78-4, SMILESS is COCCOC.Cl[Ni]Cl, Molecular C4H10Cl2NiO2, Application of 29046-78-4.

5-Cyanoimidazole was identified as an inexpensive ligand for nickel-catalyzed cross-electrophile couplings by screening a diverse set of pharmaceutical compound library. A strategic screening approach led to the discovery of this novel ligand, which was successfully applied in the preparation of various alkylated arene products with good to high yields. Furthermore, the properties of this ligand allowed expanding the scope of reductive couplings to challenging substrates, such as sterically hindered neopentyl halides, which are known to generate motifs that are prevalent in biol. active mols.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 29046-78-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Tetrakis-1,2,4,5-(bis(3,5-dimethylphenyl)phosphino)benzene (Me16tpbz): A soluble and spectroscopically simple variant of the 1,2,4,5-tetraphosphinobenzene ligand platform. Author is Selvachandran, Malathy; Kumar, Satyendra; Zhang, Xiaodong; Mague, Joel T.; Donahue, James P..

A preparation of 1,2,4,5-tetrakis(bis(3,5-dimethylphenyl)phosphino)benzene (Me16tpbz) was devised as a two-step synthesis beginning with bis(3,5-dimethylphenyl)chlorophosphine and 1,2,4,5-tetrafluorobenzene, albeit in low overall yield of 10%. The crystal structure of Me16tpbz reveals slight pushing of the P atoms above and below the central arene ring, suggesting the effect of slight steric pressure, as compared to the fully planar C6P4 core found in 1,2,4,5-tetrakis(diphenylphosphino)benzene (tpbz). Upon exposure to air, solution samples of Me16tpbz degrade to (3,5-Me2C6H3)2PP(O)(C6H3-3,5-Me2)2, identified by x-ray crystallog., which suggests P-C bond scission is a decomposition pathway. The dinickel compound [(mnt)Ni(Me16tpbz)Ni(mnt)] (mnt(2-) = [(NC)2C2S2]2-) was structurally characterized by x-ray crystallog. and reveals a chair-like conformation defined by a 32.3° angle between the NiP2 planes with respect to the central C6P4 mean plane. Compared to the analogous [(mnt)Ni(tpbz)Ni(mnt)], slightly weaker binding of Me16tpbz to Ni is implied by its modestly longer Ni-P bond lengths. The cyclic voltammogram of [(mnt)Ni(Me16tpbz)Ni(mnt)] in CH2Cl2 shows reversible reductions at ∼-1.01 V and -1.21 V, corresponding to sequential Ni2+ + e- → Ni1+ processes, while in DMF, under conditions where [(mnt)Ni(tpbz)Ni(mnt)] shows multiple, reversible reduction processes, its behavior is irreversible and more complex.

I hope my short article helps more people learn about this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)SDS of cas: 29046-78-4. Apart from the compound(29046-78-4), you can read my other articles to know other related compounds.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles